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personalized medicine

Functional neurological disorders
Cholinergic degeneration in prodromal and early Parkinson’s: a link to present and future disease states

by myneuronews May 6, 2025

by myneuronews May 6, 2025

Cholinergic System Dysfunction in Parkinson’s The cholinergic system plays a critical role in various brain …

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Functional neurological disorders
Physical-functional alterations in women with chronic migraine

by myneuronews May 6, 2025

by myneuronews May 6, 2025

Understanding chronic migraine in women Chronic migraine is a complex and debilitating neurological condition that …

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Movement Disorders
Diagnosing migraine from genome-wide genotype data: a machine learning analysis

by myneuronews May 6, 2025

by myneuronews May 6, 2025

Study Overview The prevalence of migraine, a debilitating neurological condition characterized by severe headaches often …

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Functional neurological disorders
Will adaptive deep brain stimulation for Parkinson’s disease become a real option soon? A Delphi consensus study

by myneuronews May 5, 2025

by myneuronews May 5, 2025

Adaptive Deep Brain Stimulation Approaches Adaptive deep brain stimulation (aDBS) represents a significant evolution in …

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Functional neurological disorders
Reduced microstructural white matter integrity is associated with the severity of physical symptoms in functional neurological disorder

by myneuronews May 3, 2025

by myneuronews May 3, 2025

Microstructural Changes in White Matter Research indicates that the architecture of brain white matter plays …

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Movement Disorders
Exploring the association between serotonin transporter promoter region methylation levels and depressive symptoms: a systematic review and multi-level meta-analysis

by myneuronews May 3, 2025

by myneuronews May 3, 2025

Background and Rationale The relationship between biological factors, particularly genetic and epigenetic influences, and psychological …

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Functional neurological disorders
Bilateral Focused Ultrasound Thalamotomy for Essential Tremor: Clinical Outcomes Compared to Bilateral Deep Brain Stimulation and Probabilistic Lesion Mapping

by myneuronews May 3, 2025

by myneuronews May 3, 2025

Clinical Efficacy of Thalamotomy The use of bilateral focused ultrasound thalamotomy (FUS) represents a significant …

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Functional neurological disorders
Personality assessment inventory sex differences in people with epileptic and functional seizures

by myneuronews May 1, 2025

by myneuronews May 1, 2025

Personality Traits in Epileptic Seizures The examination of personality traits among individuals experiencing epileptic seizures …

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Traumatic brain injury
Hybrid membrane-coated Cyclosporine A nanocrystals preventing secondary brain injury via alleviating neuroinflammatory and oxidative stress

by myneuronews May 1, 2025

by myneuronews May 1, 2025

Therapeutic Approach The therapeutic strategy explored in this study focuses on utilizing hybrid membrane-coated nanocrystals …

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Stroke
Proteome-Wide Genetic Study in East Asians and Europeans Identified Multiple Therapeutic Targets for Ischemic Stroke

by myneuronews April 30, 2025

by myneuronews April 30, 2025

Genetic Insights into Ischemic Stroke Ischemic stroke, a condition where blood flow to the brain …

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Understanding factors influencing the return to physical activity, perspectives of adults with concussion/mild traumatic brain injury: A qualitative study
Understanding the factors that influence the return to physical activity can help to modify behaviour to enhance the recovery of symptoms and physical activity. We conducted 14 semi-structured interviews to explore the barriers and facilitators to returning to physical activity in adults following a mild traumatic brain injury (TBI). The study design was informed by […]
Clinical Utility of the Sport Concussion Office Assessment Tool 6 (SCOAT6) and Other Select Multidomain Assessments for Subacute Sport-Related Concussion
CONCLUSIONS: The PCSI, timed tandem gait, and mVOMS components of the SCOAT6 were useful in identifying sport-related concussion. However, verbal cognitive tests, orthostatic vital signs, and clinical balance components were not useful for this purpose. The CP Screen, additional items from the full version of the VOMS, and ImPACT memory and processing speed were also […]
Persistent Post-concussion syndrome: pathophysiology, diagnosis, current and evolving treatment strategies
INTRODUCTION: Persistent post-concussion syndrome (PCS) following mild traumatic brain injury (mTBI) represents a growing global health challenge that significantly impacts patients' quality of life. Despite advances in acute concussion management, there remains a critical need for effective, evidence-based treatments for chronic PCS, as current interventions show limited success in addressing both symptoms and underlying pathophysiology.
Time-limited association between plasma transfusion and mortality in pediatric traumatic brain injury
CONCLUSION: This study reports a significant association between early plasma administration and a lower risk of 4-hour mortality among children with severe TBI that does not persist at or beyond 24 hours. While these data suggest that plasma resuscitation may extend the window for lifesaving intervention, additional prospective data are needed.
Comparing the sensitivity and specificity of novel motor assessments for traumatic brain injury
CONCLUSION: MMC-mediated tests are sensitive and specific (compared to traditional clinical tests) and have potential to fill a gap in clinical care of TBI.