Myelin Repair as a Neuroprotective Strategy for Multiple Sclerosis: From Bench to Bedside
Myelin Repair Mechanisms The central nervous system (CNS) relies heavily on myelin, a protective sheath that surrounds nerve fibers and […]
Building Towards Initiation, Moderation, De-Escalation and Cessation of Disease-Modifying Treatments for Multiple Sclerosis in Greece: An Expert Panel Consensus Meeting
Background and Rationale The landscape of Multiple Sclerosis (MS) management has evolved significantly over recent years, prompting the necessity for
Risk of Clinical Events in Presymptomatic Familial Cerebral Cavernous Malformations
Clinical Events Overview Familial cerebral cavernous malformations (CCMs) represent a genetic condition characterized by the development of vascular abnormalities within
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Primary Blast-Induced Traumatic Brain Injury as a Risk Factor for (Cerebro)vascular Disorder: Clinical Manifestations, Blast Physics, Biomechanics, Pathobiology, and Critical Gaps
Understanding Blast-Induced Brain Injury Blast-induced brain injury is a unique form of traumatic brain injury (TBI) arising primarily from the
Fasciola hepatica excretory-secretory products attenuate demyelination and reduce neuroinflammation in the Cuprizone -induced multiple sclerosis model
Background on Fasciola hepatica Fasciola hepatica, commonly known as the liver fluke, is a trematode parasite belonging to the Fasciolidae
Stiff-person syndrome; the diagnostic challenges of a treatable condition
Understanding Stiff-person Syndrome Stiff-person syndrome (SPS) is an autoimmune disorder that affects the central nervous system, resulting in severe muscle
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Seronegative Chronic Relapsing Inflammatory Optic Neuropathy
Understanding Seronegative Chronic Relapsing Inflammatory Optic Neuropathy Seronegative Chronic Relapsing Inflammatory Optic Neuropathy (CRION) is a subtype of optic neuritis
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Brainstem Encephalitis With Conflicting Autoimmune and Infectious Markers: A Case Report
Case Presentation A 45-year-old woman presented to the emergency department with an acute onset of confusion, severe headache, and altered
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Role of sirtuin 2 in the brain is cell-type and context-dependent: Implications for therapeutic targeting
Role of Sirtuin 2 in Neuronal Function Sirtuin 2 (SIRT2) is a member of the sirtuin family of proteins, which
ISG15/ISGylation in central nervous system diseases: molecular mechanisms and therapeutic targeting
Molecular Mechanisms of ISG15/ISGylation ISG15, or interferon-stimulated gene 15, is a small ubiquitin-like modifier that plays a crucial role in