Tag:

recovery outcomes

Traumatic brain injury
Injury-environment interaction: microglial priming by mTBI creates vulnerability to subsequent stress via the HMGB1-RAGE axis

by myneuronews January 10, 2026

by myneuronews January 10, 2026

Study Overview The investigation centers on the complex interplay between microglial activation and the body’s …

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Traumatic brain injury
Effects of persistent post-concussion symptoms on neurocognitive, motor, and neurophysiological outcomes

by myneuronews January 10, 2026

by myneuronews January 10, 2026

Study Overview This study investigates the long-term effects of persistent post-concussion symptoms (PPCS) on various …

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Traumatic brain injury
Incretin Mimetics as Potential Therapeutics for Concussion and Traumatic Brain Injury: A Narrative Review

by myneuronews January 10, 2026

by myneuronews January 10, 2026

Incretin Mimetics Mechanism of Action Incretin mimetics are agents that are designed to mimic the …

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Traumatic brain injury
Mechanisms and products implicated in mild traumatic brain injury among children aged 0-5 years old presenting to Canadian emergency departments

by myneuronews January 9, 2026

by myneuronews January 9, 2026

Mechanisms of Mild Traumatic Brain Injury Mild traumatic brain injury (mTBI) occurs when a child’s …

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Traumatic brain injury
Preexisting Mental Health Disorders Are Associated With Acute Clinical Presentation and Longitudinal Recovery Trajectories in Adolescents With Concussion

by myneuronews January 8, 2026

by myneuronews January 8, 2026

Study Overview The focus of this research was to investigate the relationship between preexisting mental …

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Functional neurological disorders
Mechanisms and Vulnerabilities in Functional Neurological Disorder

by myneuronews January 7, 2026

by myneuronews January 7, 2026

Mechanisms of Functional Neurological Disorder Functional Neurological Disorder (FND) encompasses a range of symptoms that …

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Functional neurological disorders
Structural brain alterations and predictors of clinical improvement in functional cognitive disorder after concussion

by myneuronews January 7, 2026

by myneuronews January 7, 2026

Structural Brain Changes in Functional Cognitive Disorder Recent studies have revealed that individuals with functional …

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Traumatic brain injury
Improving Pediatric Concussion Management in the Primary Care Setting

by myneuronews January 6, 2026

by myneuronews January 6, 2026

Pediatric Concussion Epidemiology The prevalence of concussions among children and adolescents has become a significant …

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Traumatic brain injury
The Clinical Utility of a Novel Multimodal Assessment Battery for Acute Sport-Related Concussion

by myneuronews January 6, 2026

by myneuronews January 6, 2026

Assessment Framework The evaluation of acute sport-related concussions necessitates a multidimensional approach that integrates various …

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Traumatic brain injury
Mortality and morbidity predictors in older persons with mild traumatic brain injury: A district-wide study

by myneuronews January 5, 2026

by myneuronews January 5, 2026

Study Overview The research investigates the outcomes surrounding mortality and morbidity in older individuals who …

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Incretin Mimetics as Potential Therapeutics for Concussion and Traumatic Brain Injury: A Narrative Review
Traumatic brain injury (TBI) represents a significant health concern, with an estimated 70 million annual cases worldwide. Mild brain trauma (concussions) is the most common TBI (81%), followed by moderate (11%) and severe (8%). Cytokine release and neuroinflammation after TBI may cause blood-brain barrier and tissue damage, triggering unfavorable outcomes, including disabilities and mortality. Current […]
N-Stearidonoylethanolamine Restores CA1 Synaptic Integrity and Reduces Astrocytic Reactivity After Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI) disrupts hippocampal network function through coordinated alterations in glial reactivity, synaptic integrity, and adult neurogenesis. Effective therapeutic approaches targeting these interconnected processes remain limited. Lipid-derived molecules capable of modulating these mTBI-induced disturbances are emerging as promising neuroprotective candidates. Here, we investigated the effects of N-stearidonylethanolamine (SDEA), an ω-3 ethanolamide, in […]
Effects of persistent post-concussion symptoms on neurocognitive, motor, and neurophysiological outcomes
CONCLUSION: The PPCS group demonstrated greater symptom reporting and severity, worse neurocognitive performance, worse balance and gait performance, and altered neurophysiology. Further, females with PPCS demonstrated worse balance and gait performance compared to all other groups.
Injury-environment interaction: microglial priming by mTBI creates vulnerability to subsequent stress via the HMGB1-RAGE axis
CONCLUSION: Our study untangles a "priming-triggering" mechanism of injury-environment interaction, identifying the HMGB1-RAGE axis as its key molecular mediator. This finding not only enhances our understanding of how latent vulnerability transitions into overt neuropsychiatric disease, but also provides a promising target for preventive intervention.
Relationship between illness perceptions, coping style and post-concussion symptoms after systemic traumatic injury: A comparison of those with and without mild traumatic brain injury
Research has reported variable findings when investigating the relationship between outcome and coping style and illness perceptions after mild traumatic brain injury (mTBI). The present study investigated 138 individuals who had been admitted to hospital after suffering a traumatic systemic injury, with 91 of these individuals also fulfilling criteria for mTBI and 47 comprising a […]