Tag:

symptoms

Dementia
Intranasal Delivery of BACE1 siRNA and Berberine via Engineered Stem Cell Exosomes for the Treatment of Alzheimer’s Disease

by myneuronews May 12, 2025

by myneuronews May 12, 2025

Treatment Strategy Overview In recent years, the exploration of innovative approaches to treat Alzheimer’s disease …

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Headaches
Current Evidence in the Management of Central Skull Base Osteomyelitis: A Systematic Review

by myneuronews May 12, 2025

by myneuronews May 12, 2025

Study Overview Central Skull Base Osteomyelitis (CSBO) is a serious infection that affects the bony …

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Functional neurological disorders
Association of type 1 stiff-person syndrome and insulinoma: a case report and narrative review

by myneuronews May 12, 2025

by myneuronews May 12, 2025

Clinical Presentation and Diagnosis The clinical presentation of type 1 stiff-person syndrome (SPS) characterized by …

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Functional neurological disorders
Automated seizure detection in epilepsy using a novel dynamic temporal-spatial graph attention network

by myneuronews May 12, 2025

by myneuronews May 12, 2025

Methodology and Model Architecture The study introduces a sophisticated machine learning approach aimed at enhancing …

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Functional neurological disorders
Apolipoprotein E (APOE) and Alzheimer’s disease risk in a Ugandan population: A pilot case-control study

by myneuronews May 12, 2025

by myneuronews May 12, 2025

Apolipoprotein E Genotypes and Alzheimer’s Disease The study investigated the relationship between different genotypes of …

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Functional neurological disorders
Nocebo Hypothesis Cognitive Behavioral Therapy for Functional Neurological Symptom Disorder (Motor Type): A Pilot Randomized Controlled Trial

by myneuronews May 12, 2025

by myneuronews May 12, 2025

Background and Rationale Functional Neurological Disorder (FND) is a complex condition characterized by neurological symptoms …

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Functional neurological disorders
Giant Rectal Fecaloma Treated with Carbonated Soft Drink and Argon Plasma Coagulation

by myneuronews May 12, 2025

by myneuronews May 12, 2025

Case Presentation In this case study, we encounter a 65-year-old female patient who presented with …

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Functional neurological disorders
Assessing Morbidity and Outcomes of Posterior Lumbar Fusion in Elderly Patients: A Systematic Review and Meta-Analysis

by myneuronews May 12, 2025

by myneuronews May 12, 2025

Morbidity Assessment in Elderly Patients In the study analyzing the morbidity associated with posterior lumbar …

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Functional neurological disorders
Association of type 1 stiff-person syndrome and insulinoma: a case report and narrative review

by myneuronews May 12, 2025

by myneuronews May 12, 2025

Clinical Presentation and Diagnosis The clinical presentation of type 1 stiff-person syndrome (SPS) and its …

Read more

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Functional neurological disorders
Nocebo Hypothesis Cognitive Behavioral Therapy for Functional Neurological Symptom Disorder (Motor Type): A Pilot Randomized Controlled Trial

by myneuronews May 12, 2025

by myneuronews May 12, 2025

Background and Rationale The investigation into the nocebo phenomenon, particularly within the context of cognitive …

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Real-world assessment of current migraine prophylaxis in Egypt: a multicenter national study
Study Overview The research conducted aimed to evaluate the existing practices regarding migraine prophylaxis across…
Treatment of Alzheimer’s disease from gut-brain interactions based on theory of “spleen deficiency leading to obstruction of nine orifices”
Understanding Gut-Brain Interactions The relationship between the gut and the brain is increasingly recognized as…
Update on functional vestibular and gait disorders
Current Understanding of Vestibular and Gait Disorders Vestibular and gait disorders have increasingly garnered attention…
Brain creatine concentrations are associated with sex and symptom severity after concussion: a cross-sectional MR-spectroscopy investigation of adolescents with concussion
Study Overview The investigation focused on the relationship between brain creatine concentrations and both sex…
Anti-Inflammatory Potential of Stearidonic Acid Ethanolamide in a Model of Mild Traumatic Brain Injury in Mice
Study Overview This study investigates the effects of stearidonic acid ethanolamide (SDA-EA) on inflammation following…

Incretin Mimetics as Potential Therapeutics for Concussion and Traumatic Brain Injury: A Narrative Review
Traumatic brain injury (TBI) represents a significant health concern, with an estimated 70 million annual cases worldwide. Mild brain trauma (concussions) is the most common TBI (81%), followed by moderate (11%) and severe (8%). Cytokine release and neuroinflammation after TBI may cause blood-brain barrier and tissue damage, triggering unfavorable outcomes, including disabilities and mortality. Current […]
N-Stearidonoylethanolamine Restores CA1 Synaptic Integrity and Reduces Astrocytic Reactivity After Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI) disrupts hippocampal network function through coordinated alterations in glial reactivity, synaptic integrity, and adult neurogenesis. Effective therapeutic approaches targeting these interconnected processes remain limited. Lipid-derived molecules capable of modulating these mTBI-induced disturbances are emerging as promising neuroprotective candidates. Here, we investigated the effects of N-stearidonylethanolamine (SDEA), an ω-3 ethanolamide, in […]
Effects of persistent post-concussion symptoms on neurocognitive, motor, and neurophysiological outcomes
CONCLUSION: The PPCS group demonstrated greater symptom reporting and severity, worse neurocognitive performance, worse balance and gait performance, and altered neurophysiology. Further, females with PPCS demonstrated worse balance and gait performance compared to all other groups.
Injury-environment interaction: microglial priming by mTBI creates vulnerability to subsequent stress via the HMGB1-RAGE axis
CONCLUSION: Our study untangles a "priming-triggering" mechanism of injury-environment interaction, identifying the HMGB1-RAGE axis as its key molecular mediator. This finding not only enhances our understanding of how latent vulnerability transitions into overt neuropsychiatric disease, but also provides a promising target for preventive intervention.
Relationship between illness perceptions, coping style and post-concussion symptoms after systemic traumatic injury: A comparison of those with and without mild traumatic brain injury
Research has reported variable findings when investigating the relationship between outcome and coping style and illness perceptions after mild traumatic brain injury (mTBI). The present study investigated 138 individuals who had been admitted to hospital after suffering a traumatic systemic injury, with 91 of these individuals also fulfilling criteria for mTBI and 47 comprising a […]