Tag:

symptoms

Movement Disorders
Tics and Parkinson’s Disease: Clinical and Pathophysiological Insights from a Rare Syndromic Association

by myneuronews April 30, 2025

by myneuronews April 30, 2025

Understanding Tics in Parkinson’s Disease Tics are sudden, repetitive movements or vocalizations that can occur …

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Traumatic brain injury
Use of physical exertion to enhance objective testing following mild traumatic brain injury: a systematic review

by myneuronews April 30, 2025

by myneuronews April 30, 2025

Physical Exertion as a Rehabilitation Strategy Physical exertion has gained recognition as a potential rehabilitative …

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Traumatic brain injury
Clinical comparisons between post-traumatic headache and migraine: A cross-sectional study

by myneuronews April 30, 2025

by myneuronews April 30, 2025

Study Overview This study examined the clinical characteristics of post-traumatic headaches (PTH) in comparison to …

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Headaches
Efficacy, safety, and tolerability of chenodeoxycholic acid (CDCA) in adult patients with cerebrotendinous xanthomatosis (RESTORE): a randomized withdrawal, double-blind, placebo-controlled, crossover phase 3 study

by myneuronews April 29, 2025

by myneuronews April 29, 2025

Efficacy of Chenodeoxycholic Acid Chenodeoxycholic acid (CDCA) has emerged as a critical therapeutic option for …

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Traumatic brain injury
Clinical Cut Point for the Pittsburgh Sleep Quality Index After Adolescent Concussion

by myneuronews April 29, 2025

by myneuronews April 29, 2025

Clinical Relevance of Sleep Quality Sleep quality is a pivotal aspect of overall health and …

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Functional neurological disorders
Neuroimaging Biomarkers of Post-acute Sequelae of Covid (PASC)

by myneuronews April 29, 2025

by myneuronews April 29, 2025

Neuroimaging Techniques and PASC Neuroimaging techniques have emerged as powerful tools in understanding the neurological …

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Functional neurological disorders
Identification and Functional Analysis of Cystathionine Beta-Synthase Gene Mutations in Chinese Families with Classical Homocystinuria

by myneuronews April 29, 2025

by myneuronews April 29, 2025

Genetic Background of Homocystinuria Homocystinuria is a rare, inherited metabolic disorder primarily characterized by an …

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Functional neurological disorders
Silencer variants are key drivers of gene upregulation in Alzheimer’s disease

by myneuronews April 29, 2025

by myneuronews April 29, 2025

Silencer Variants and Gene Regulation Recent advancements in genetic research have shed light on the …

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Functional neurological disorders
Regulation of chronic neuroinflammation through dietary herbal products

by myneuronews April 29, 2025

by myneuronews April 29, 2025

Role of Dietary Herbal Products in Neuroinflammation Dietary herbal products have garnered significant interest in …

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Traumatic brain injury
Retinal manifestations of traumatic brain injury

by myneuronews April 29, 2025

by myneuronews April 29, 2025

Retinal Changes Associated with Traumatic Brain Injury Traumatic brain injury (TBI) can lead to various …

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Decreased IL-33 in the brain following repetitive mild traumatic brain injury contributes to cognitive impairment by inhibiting microglial phagocytosis
CONCLUSIONS: Dysfunction of the IL-33/ST2 axis following rmTBI leads to cognitive dysfunction via impairing microglial phagocytosis capacity and promoting neuronal damage. IL-33 would be a promising therapeutic target for alleviating neurodegeneration following rmTBI.
Multidisciplinary rehabilitation and follow-up for children hospitalized with traumatic brain injury
PurposeMost children hospitalized with traumatic brain injury (TBI) acquire new impairments that impact function and health-related quality of life. However, there is a lack of standardized, multidisciplinary, longitudinal rehabilitative services for children with TBI.MethodsThis single center, retrospective study evaluated rehabilitative services during acute hospitalization and identified the frequency of unmet needs, defined as new or […]
Tackle characteristics associated with concussion in elite men's rugby union: unpicking the differences between tacklers and ball-carriers
CONCLUSIONS: Lower tackles reduce the chances of concussion to ball-carriers. The influence of tackle height on concussion to tacklers is more nuanced, but the chances are relatively low when contact is made with the ball-carrier's torso. These findings support ongoing implementation of strategies to reduce concussion risk by lowering tackle height to target the torso.
Development of a modified weight-drop apparatus for closed-skull, repetitive mild traumatic brain injuries in a mouse model
Repetitive mild traumatic brain injury (rmTBI) is a major contributor to long-term neurological dysfunction, yet many preclinical models lack precise control and quantification of biomechanical forces across impacts. We developed a reproducible, closed-skull mouse model of rmTBI using a custom-built weight-drop apparatus featuring a solenoid-based rebound arrest system, integrated high-speed videography, and accelerometry to track […]
Pretreatment with an anti-CGRP monoclonal antibody attenuates mild TBI-induced tactile hypersensitivity in mice
CONCLUSIONS: These results indicate that an anti-CGRP mAb can partially, but not fully, attenuate cephalic tactile hypersensitivity when administered immediately before or after the mTBI event. In contrast, a stronger rescue was seen when the anti-CGRP mAb was administered just prior to CGRP and nitric oxide triggers. Thus, depending on the timing of administration, the […]