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Tau

Traumatic brain injury
Concussive injuries induce neuronal stress-dependent tau mislocalization to dendritic spines with acrolein and functional network alteration in TBI-on-a-chip

by myneuronews September 11, 2025

by myneuronews September 11, 2025

Study Overview This research focuses on the cellular mechanisms involved in concussive injuries, specifically examining …

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Traumatic brain injury
Boston University Alzheimer’s Disease Research Center Clinical Core: Infrastructure to facilitate research on post-traumatic Alzheimer’s disease and related dementias

by myneuronews September 9, 2025

by myneuronews September 9, 2025

Research Objectives The primary aim of the Boston University Alzheimer’s Disease Research Center’s Clinical Core …

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Dementia
Boston University Alzheimer’s Disease Research Center Clinical Core: Infrastructure to facilitate research on post-traumatic Alzheimer’s disease and related dementias

by myneuronews September 9, 2025

by myneuronews September 9, 2025

Research Objectives The primary aim of the Boston University Alzheimer’s Disease Research Center Clinical Core …

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Traumatic brain injury
Associations between traumatic brain injury and the prevalence of Alzheimer’s disease dementia and behavioral and psychological symptoms of dementia: A retrospective cohort study

by myneuronews August 29, 2025

by myneuronews August 29, 2025

Associations between TBI and Alzheimer’s Disease Traumatic brain injury (TBI) has garnered significant interest as …

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Traumatic brain injury
Chronic traumatic encephalopathy

by myneuronews August 29, 2025

by myneuronews August 29, 2025

Pathophysiology of Chronic Traumatic Encephalopathy Chronic traumatic encephalopathy (CTE) is a neurodegenerative condition associated with …

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Dementia
High-affinity transferrin receptor binding improves brain delivery of bispecific antibodies at tracer dose

by myneuronews August 22, 2025

by myneuronews August 22, 2025

Study Overview The research focused on improving the delivery of bispecific antibodies to the brain. …

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Traumatic brain injury
From imaging to intervention: emerging potential of PET biomarkers to shape therapeutic strategies for TBI-induced neurodegeneration

by myneuronews August 21, 2025

by myneuronews August 21, 2025

Emerging Role of PET Biomarkers in TBI Positron Emission Tomography (PET) has gained increasing recognition …

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Dementia
Vascular Contributions to Cognitive Impairment and Dementia in the United States: Prevalence and Incidence: A Scientific Statement From the American Heart Association

by myneuronews August 18, 2025

by myneuronews August 18, 2025

Vascular Contributions to Cognitive Health The relationship between vascular health and cognitive function is a …

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Dementia
The burden of cognitive impairment

by myneuronews August 14, 2025

by myneuronews August 14, 2025

Understanding Cognitive Impairment Cognitive impairment encompasses a variety of conditions that affect an individual’s ability …

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Traumatic brain injury
A voice for Tom: an urgent call for more research into neurodegenerative disease and contact sport

by myneuronews July 29, 2025

by myneuronews July 29, 2025

Neurodegenerative Disease and Contact Sports Neurodegenerative diseases represent a broad category of disorders characterized by …

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Association of serum inflammasome proteins and pediatric traumatic brain injury severity
BACKGROUND: Pediatric traumatic brain injury (pTBI) often leads to cognitive, behavioral, and motor impairments. NLRP3 inflammasome proteins, such as ASC and caspase-1, may serve as biomarkers for TBI severity due to their role in neuroinflammation. This study aims to assess the association between serum ASC and caspase-1 levels and TBI severity in pediatric patients.
Linking a Deep Learning Model for Concussion Classification with Reorganization of Large-Scale Brain Networks in Female Youth
Concussion, or mild traumatic brain injury, is a significant public health challenge, with females experiencing high rates and prolonged symptoms. Reliable and objective tools for early diagnosis are critically needed, particularly in pediatric populations, where subjective symptom reporting can be inconsistent and neurodevelopmental factors may influence presentation. Five minutes of resting-state (RS) EEG data were […]
Neuroprotective Effects of Low-Intensity Pulsed Ultrasound in Chronic Traumatic Encephalopathy Induced by Repetitive Head Collisions: A Narrative Review
The repeated head impacts experienced by athletes have attracted significant interest from both the public and the scientific community; however, the neurobiological effects following the games are not well understood. For example, a single football match carries the risk of repeated concussive and subconcussive head impacts, which can increase the risk of developing neurodegenerative diseases. […]
Comparative predictive validity of a psychological risk screening tool in adults after mild traumatic brain injury
CONCLUSIONS: The STarT-C showed comparable prognostic value for post-concussion symptom outcomes with a battery of psychological questionnaires. Further research should consider if stratified risk using STarT-C high, medium, and low sub-categories improves targeted treatment referral decision making by clinicians and mTBI outcomes.
Brain injury contributes to dopaminergic neurodegeneration, Lewy body pathology, and Parkinsonism preclinically with outcomes altered by T cell modulation
Traumatic brain injury (TBI) increases the risk of Parkinson's disease (PD) development later in life, but much remains unknown regarding the mechanisms driving this relationship. A single, mild brain injury triggers resident and peripheral neuroinflammatory pathways that are similarly activated in PD patients, which could possibly increase susceptibility to neurodegeneration. In this study, we used […]