Tag:

Tau

Dementia
Treatment of Alzheimer’s disease from gut-brain interactions based on theory of “spleen deficiency leading to obstruction of nine orifices”

by myneuronews January 8, 2026

by myneuronews January 8, 2026

Understanding Gut-Brain Interactions The relationship between the gut and the brain is increasingly recognized as …

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Traumatic brain injury
Repetitive mild traumatic brain injury with the closed-head impact model of engineered rotational acceleration (CHIMERA) promotes tau pathology in tau transgenic mice and its propagation in brains injected with tau fibrils

by myneuronews January 8, 2026

by myneuronews January 8, 2026

Study Overview This study investigates the effects of repetitive mild traumatic brain injury (rmTBI) on …

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Dementia
Plasma extracellular vesicles and phosphorylated tau 181 as early biomarkers of cognitive impairment in Alzheimer’s dementia

by myneuronews January 6, 2026

by myneuronews January 6, 2026

Study Overview The focus of this research is on exploring the potential of plasma extracellular …

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Dementia
GASDERMIN D-mediated pyroptosis as a therapeutic target in TAU-dependent frontotemporal dementia mouse model

by myneuronews January 4, 2026

by myneuronews January 4, 2026

Study Overview The research focuses on the role of GASDERMIN D in the context of …

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Traumatic brain injury
Plasma biomarkers in chronic mild traumatic brain injury: A review

by myneuronews December 31, 2025

by myneuronews December 31, 2025

Biomarkers in Chronic Mild Traumatic Brain Injury Chronic mild traumatic brain injury (mTBI), commonly associated …

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Traumatic brain injury
Biomarkers

by myneuronews December 26, 2025

by myneuronews December 26, 2025

Biomarker Definition and Types Biomarkers, or biological markers, are quantifiable indicators of biological processes, pathological …

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Traumatic brain injury
Biomarkers

by myneuronews December 25, 2025

by myneuronews December 25, 2025

Biomarker Definition and Significance Biomarkers are measurable indicators that reflect biological processes, pathogenic processes, or …

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Traumatic brain injury
Biomarkers

by myneuronews December 25, 2025

by myneuronews December 25, 2025

Definition and Types Biomarkers are measurable indicators that reflect physiological, pathological processes, or responses to …

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Dementia
The biomarker and clinical changes across the Alzheimer’s continuum study (BCAS): rationale, design, and baseline characteristics of the first 1,013 participants

by myneuronews December 23, 2025

by myneuronews December 23, 2025

Study Overview The BCAS study focuses on understanding the progression of Alzheimer’s disease through a …

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Dementia
Consideration of sex as a biological variable over the history of the 5xFAD Alzheimer’s Disease mouse model

by myneuronews December 17, 2025

by myneuronews December 17, 2025

Biological Considerations When investigating Alzheimer’s disease through animal models, particularly the 5xFAD mouse model, it …

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Real-world assessment of current migraine prophylaxis in Egypt: a multicenter national study
Study Overview The research conducted aimed to evaluate the existing practices regarding migraine prophylaxis across…
Treatment of Alzheimer’s disease from gut-brain interactions based on theory of “spleen deficiency leading to obstruction of nine orifices”
Understanding Gut-Brain Interactions The relationship between the gut and the brain is increasingly recognized as…
Update on functional vestibular and gait disorders
Current Understanding of Vestibular and Gait Disorders Vestibular and gait disorders have increasingly garnered attention…
Brain creatine concentrations are associated with sex and symptom severity after concussion: a cross-sectional MR-spectroscopy investigation of adolescents with concussion
Study Overview The investigation focused on the relationship between brain creatine concentrations and both sex…
Anti-Inflammatory Potential of Stearidonic Acid Ethanolamide in a Model of Mild Traumatic Brain Injury in Mice
Study Overview This study investigates the effects of stearidonic acid ethanolamide (SDA-EA) on inflammation following…

Incretin Mimetics as Potential Therapeutics for Concussion and Traumatic Brain Injury: A Narrative Review
Traumatic brain injury (TBI) represents a significant health concern, with an estimated 70 million annual cases worldwide. Mild brain trauma (concussions) is the most common TBI (81%), followed by moderate (11%) and severe (8%). Cytokine release and neuroinflammation after TBI may cause blood-brain barrier and tissue damage, triggering unfavorable outcomes, including disabilities and mortality. Current […]
N-Stearidonoylethanolamine Restores CA1 Synaptic Integrity and Reduces Astrocytic Reactivity After Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI) disrupts hippocampal network function through coordinated alterations in glial reactivity, synaptic integrity, and adult neurogenesis. Effective therapeutic approaches targeting these interconnected processes remain limited. Lipid-derived molecules capable of modulating these mTBI-induced disturbances are emerging as promising neuroprotective candidates. Here, we investigated the effects of N-stearidonylethanolamine (SDEA), an ω-3 ethanolamide, in […]
Relationship between illness perceptions, coping style and post-concussion symptoms after systemic traumatic injury: A comparison of those with and without mild traumatic brain injury
Research has reported variable findings when investigating the relationship between outcome and coping style and illness perceptions after mild traumatic brain injury (mTBI). The present study investigated 138 individuals who had been admitted to hospital after suffering a traumatic systemic injury, with 91 of these individuals also fulfilling criteria for mTBI and 47 comprising a […]
Injury-induced CTE-like pathology emerges in a human multicellular in vitro brain model and reveals mitochondrial and neurovascular regulation
Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease linked to repetitive mild head impacts, but no human-based experimental system exists to study injury-induced CTE-like pathology. Here, we establish a long-lived, human multicellular in vitro brain platform in which controlled mechanical injury induces key cellular features of CTE-like pathology. Injured cultures developed persistent tau phosphorylation, […]
Explosive shock wave exposure leads to age-accelerated motor and sensory decline in C. elegans
CONCLUSIONS: Defined shock wave exposure is sufficient to provoke long-term neuronal functional decline in C. elegans , accompanied by structural deterioration and premature neurodegeneration. This tractable model enables lifelong phenotyping and mechanistic dissection of how an acute shock wave insult progresses to chronic neuronal dysfunction, and provides a scalable platform for identifying molecular and pharmacological […]