Tag:

Tau

Dementia
Disclosure of onset-predictive biomarker results to research participants at risk of genetic frontotemporal dementia: a European perspective

by myneuronews December 13, 2025

by myneuronews December 13, 2025

Background on Genetic Frontotemporal Dementia Genetic frontotemporal dementia (FTD) is a group of neurodegenerative disorders …

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Dementia
The CSF Levels of Mitochondrial Phosphoenolpyruvate Carboxykinase 2 as a Novel Biomarker in Alzheimer’s Disease

by myneuronews November 19, 2025

by myneuronews November 19, 2025

Study Overview The research focuses on the role of mitochondrial phosphoenolpyruvate carboxykinase 2 (PEPCK-M) levels …

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Traumatic brain injury
Long intervals between repetitive concussions reduce risk of cognitive impairment and limit microglial activation, astrogliosis, and tauopathy in adolescent rats

by myneuronews November 18, 2025

by myneuronews November 18, 2025

Impact of Concussion Intervals on Cognitive Outcomes Research indicates that the timing between concussive events …

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Dementia
In an older-age vascular cohort, carotid stenosis is associated with processing speed and executive function cognitive deficits, which correlate with p-tau217

by myneuronews November 17, 2025

by myneuronews November 17, 2025

Study Overview The research focused on understanding the relationship between carotid stenosis and cognitive deficits …

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Traumatic brain injury
Biomarkers for prediction of chronic traumatic encephalopathy-like pathology following repeated mild traumatic brain injury in rats are partially sex- and age-dependent

by myneuronews November 16, 2025

by myneuronews November 16, 2025

Study Overview The research embarked on an investigation into the long-term effects of repeated mild …

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Traumatic brain injury
Chronic Traumatic Encephalopathy Neuropathologic Change in Military Veterans

by myneuronews November 10, 2025

by myneuronews November 10, 2025

Pathophysiology of Chronic Traumatic Encephalopathy Chronic Traumatic Encephalopathy (CTE) is a degenerative brain disease commonly …

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Traumatic brain injury
Therapeutic VEGFC treatment provides protection against traumatic-brain-injury-driven tauopathy pathogenesis

by myneuronews November 8, 2025

by myneuronews November 8, 2025

Therapeutic Efficacy of VEGFC The treatment of traumatic brain injury (TBI) has been a significant …

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Dementia
Systematic post-translational modification genome wide identifies therapeutic targets for Alzheimer’s disease: evidence from multi-cohort analysis

by myneuronews October 30, 2025

by myneuronews October 30, 2025

Identifying Therapeutic Targets In recent years, identifying therapeutic targets for Alzheimer’s disease (AD) has gained …

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Traumatic brain injury
Repetitive head impacts, repeat concussions, and chronic traumatic encephalopathy: Introductory editorial for a special issue

by myneuronews October 18, 2025

by myneuronews October 18, 2025

Repetitive head impacts and their effects Repetitive head impacts, often experienced in contact sports and …

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Traumatic brain injury
Concussive injuries induce neuronal stress-dependent tau mislocalization to dendritic spines with acrolein and functional network alteration in TBI-on-a-chip

by myneuronews September 11, 2025

by myneuronews September 11, 2025

Study Overview This research focuses on the cellular mechanisms involved in concussive injuries, specifically examining …

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Real-world assessment of current migraine prophylaxis in Egypt: a multicenter national study
Study Overview The research conducted aimed to evaluate the existing practices regarding migraine prophylaxis across…
Treatment of Alzheimer’s disease from gut-brain interactions based on theory of “spleen deficiency leading to obstruction of nine orifices”
Understanding Gut-Brain Interactions The relationship between the gut and the brain is increasingly recognized as…
Update on functional vestibular and gait disorders
Current Understanding of Vestibular and Gait Disorders Vestibular and gait disorders have increasingly garnered attention…
Brain creatine concentrations are associated with sex and symptom severity after concussion: a cross-sectional MR-spectroscopy investigation of adolescents with concussion
Study Overview The investigation focused on the relationship between brain creatine concentrations and both sex…
Anti-Inflammatory Potential of Stearidonic Acid Ethanolamide in a Model of Mild Traumatic Brain Injury in Mice
Study Overview This study investigates the effects of stearidonic acid ethanolamide (SDA-EA) on inflammation following…

Incretin Mimetics as Potential Therapeutics for Concussion and Traumatic Brain Injury: A Narrative Review
Traumatic brain injury (TBI) represents a significant health concern, with an estimated 70 million annual cases worldwide. Mild brain trauma (concussions) is the most common TBI (81%), followed by moderate (11%) and severe (8%). Cytokine release and neuroinflammation after TBI may cause blood-brain barrier and tissue damage, triggering unfavorable outcomes, including disabilities and mortality. Current […]
N-Stearidonoylethanolamine Restores CA1 Synaptic Integrity and Reduces Astrocytic Reactivity After Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI) disrupts hippocampal network function through coordinated alterations in glial reactivity, synaptic integrity, and adult neurogenesis. Effective therapeutic approaches targeting these interconnected processes remain limited. Lipid-derived molecules capable of modulating these mTBI-induced disturbances are emerging as promising neuroprotective candidates. Here, we investigated the effects of N-stearidonylethanolamine (SDEA), an ω-3 ethanolamide, in […]
Relationship between illness perceptions, coping style and post-concussion symptoms after systemic traumatic injury: A comparison of those with and without mild traumatic brain injury
Research has reported variable findings when investigating the relationship between outcome and coping style and illness perceptions after mild traumatic brain injury (mTBI). The present study investigated 138 individuals who had been admitted to hospital after suffering a traumatic systemic injury, with 91 of these individuals also fulfilling criteria for mTBI and 47 comprising a […]
Injury-induced CTE-like pathology emerges in a human multicellular in vitro brain model and reveals mitochondrial and neurovascular regulation
Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease linked to repetitive mild head impacts, but no human-based experimental system exists to study injury-induced CTE-like pathology. Here, we establish a long-lived, human multicellular in vitro brain platform in which controlled mechanical injury induces key cellular features of CTE-like pathology. Injured cultures developed persistent tau phosphorylation, […]
Explosive shock wave exposure leads to age-accelerated motor and sensory decline in C. elegans
CONCLUSIONS: Defined shock wave exposure is sufficient to provoke long-term neuronal functional decline in C. elegans , accompanied by structural deterioration and premature neurodegeneration. This tractable model enables lifelong phenotyping and mechanistic dissection of how an acute shock wave insult progresses to chronic neuronal dysfunction, and provides a scalable platform for identifying molecular and pharmacological […]