Tag:

TBI

Traumatic brain injury
Blood Biomarkers as Optimization Tools for Computed Tomography in Mild Traumatic Brain Injury Management in Emergency Departments: A Systematic Review

by myneuronews August 27, 2025

by myneuronews August 27, 2025

Blood Biomarkers and Their Role Blood biomarkers are measurable substances in the blood that can …

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Traumatic brain injury
Newly Identified Suicidal Ideation and Suicide Attempts Among Military Service Members Following Traumatic Brain Injury, by Sex

by myneuronews August 22, 2025

by myneuronews August 22, 2025

Background and Context Recent categorization of mental health issues among military service members has highlighted …

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Traumatic brain injury
From imaging to intervention: emerging potential of PET biomarkers to shape therapeutic strategies for TBI-induced neurodegeneration

by myneuronews August 21, 2025

by myneuronews August 21, 2025

Emerging Role of PET Biomarkers in TBI Positron Emission Tomography (PET) has gained increasing recognition …

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Traumatic brain injury
Disparities in provision of rehabilitative services in adolescents with traumatic brain injury at level I adult versus pediatric trauma centers

by myneuronews August 21, 2025

by myneuronews August 21, 2025

Service Disparities The provision of rehabilitative services to adolescents who have experienced traumatic brain injury …

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Traumatic brain injury
Perampanel for alleviation of secondary injury in traumatic brain injury (PEACE-TBI): a protocol for a phase-II multicentre randomised clinical trial

by myneuronews August 19, 2025

by myneuronews August 19, 2025

Study Overview The clinical trial, known as PEACE-TBI, is designed to evaluate the effectiveness of …

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Traumatic brain injury
A Randomized Sham-Controlled Trial of Heart Rate Variability Biofeedback Following Traumatic Brain Injury (TBI)

by myneuronews August 19, 2025

by myneuronews August 19, 2025

Study Overview The trial aimed to assess the effectiveness of heart rate variability biofeedback as …

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Traumatic brain injury
Low Utility and Yield of Routine Outpatient CT Imaging in Patients With Mild Traumatic Brain Injury and Intracranial Hemorrhage

by myneuronews August 18, 2025

by myneuronews August 18, 2025

Study Overview The research critically examines the utility of routine outpatient computed tomography (CT) imaging …

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Traumatic brain injury
Impact of oxygen and carbon dioxide levels on mortality in moderate to severe traumatic brain injury: a systematic review and meta-analysis

by myneuronews August 15, 2025

by myneuronews August 15, 2025

Study Overview This systematic review and meta-analysis focus on the correlation between oxygen and carbon …

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Traumatic brain injury
Glasgow Coma Scale Score at Admission in Traumatic Brain Injury Patients: A Multicenter Observational Analysis

by myneuronews August 14, 2025

by myneuronews August 14, 2025

Study Overview This multicenter observational analysis focuses on the role of the Glasgow Coma Scale …

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Traumatic brain injury
Glasgow Coma Scale Score at Admission in Traumatic Brain Injury Patients: A Multicenter Observational Analysis

by myneuronews August 14, 2025

by myneuronews August 14, 2025

Study Overview The purpose of this research was to assess the Glasgow Coma Scale (GCS) …

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Incretin Mimetics as Potential Therapeutics for Concussion and Traumatic Brain Injury: A Narrative Review
Traumatic brain injury (TBI) represents a significant health concern, with an estimated 70 million annual cases worldwide. Mild brain trauma (concussions) is the most common TBI (81%), followed by moderate (11%) and severe (8%). Cytokine release and neuroinflammation after TBI may cause blood-brain barrier and tissue damage, triggering unfavorable outcomes, including disabilities and mortality. Current […]
N-Stearidonoylethanolamine Restores CA1 Synaptic Integrity and Reduces Astrocytic Reactivity After Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI) disrupts hippocampal network function through coordinated alterations in glial reactivity, synaptic integrity, and adult neurogenesis. Effective therapeutic approaches targeting these interconnected processes remain limited. Lipid-derived molecules capable of modulating these mTBI-induced disturbances are emerging as promising neuroprotective candidates. Here, we investigated the effects of N-stearidonylethanolamine (SDEA), an ω-3 ethanolamide, in […]
Effects of persistent post-concussion symptoms on neurocognitive, motor, and neurophysiological outcomes
CONCLUSION: The PPCS group demonstrated greater symptom reporting and severity, worse neurocognitive performance, worse balance and gait performance, and altered neurophysiology. Further, females with PPCS demonstrated worse balance and gait performance compared to all other groups.
Injury-environment interaction: microglial priming by mTBI creates vulnerability to subsequent stress via the HMGB1-RAGE axis
CONCLUSION: Our study untangles a "priming-triggering" mechanism of injury-environment interaction, identifying the HMGB1-RAGE axis as its key molecular mediator. This finding not only enhances our understanding of how latent vulnerability transitions into overt neuropsychiatric disease, but also provides a promising target for preventive intervention.
Relationship between illness perceptions, coping style and post-concussion symptoms after systemic traumatic injury: A comparison of those with and without mild traumatic brain injury
Research has reported variable findings when investigating the relationship between outcome and coping style and illness perceptions after mild traumatic brain injury (mTBI). The present study investigated 138 individuals who had been admitted to hospital after suffering a traumatic systemic injury, with 91 of these individuals also fulfilling criteria for mTBI and 47 comprising a […]