Tag:

treatment strategies

Dementia
Intranasal Delivery of BACE1 siRNA and Berberine via Engineered Stem Cell Exosomes for the Treatment of Alzheimer’s Disease

by myneuronews May 12, 2025

by myneuronews May 12, 2025

Treatment Strategy Overview In recent years, the exploration of innovative approaches to treat Alzheimer’s disease …

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Movement Disorders
A Rare Case of Bilateral Xanthomatosis of Tendon of Achilles: A Case Report

by myneuronews May 12, 2025

by myneuronews May 12, 2025

Background of Bilateral Xanthomatosis Bilateral xanthomatosis is a rare condition characterized by the accumulation of …

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Functional neurological disorders
Fresh Rehmanniae Radix regulates cholesterol metabolism disorder in mice fed with high-fat and high-cholesterol diet via FXR-mediated bile acid reabsorption

by myneuronews May 12, 2025

by myneuronews May 12, 2025

Effects of Fresh Rehmanniae Radix on Cholesterol Metabolism The research findings indicate that Fresh Rehmanniae …

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Functional neurological disorders
Association of type 1 stiff-person syndrome and insulinoma: a case report and narrative review

by myneuronews May 12, 2025

by myneuronews May 12, 2025

Clinical Presentation and Diagnosis The clinical presentation of type 1 stiff-person syndrome (SPS) characterized by …

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Functional neurological disorders
Apolipoprotein E (APOE) and Alzheimer’s disease risk in a Ugandan population: A pilot case-control study

by myneuronews May 12, 2025

by myneuronews May 12, 2025

Apolipoprotein E Genotypes and Alzheimer’s Disease The study investigated the relationship between different genotypes of …

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Functional neurological disorders
Stroke-Like Symptoms Status-Post Tenecteplase (TNK) Administration: A Rare Case of Hemiplegic Migraine

by myneuronews May 9, 2025

by myneuronews May 9, 2025

Clinical Presentation and Background In the context of acute neurological symptoms, the clinical presentation is …

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Dementia
Unraveling sex differences in Alzheimer’s disease and related endophenotypes with brain proteomes

by myneuronews May 9, 2025

by myneuronews May 9, 2025

Research Context The study of Alzheimer’s disease (AD) has gained considerable momentum as researchers explore …

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Movement Disorders
The prodromal individuals’ perspective on active recruitment for early detection of α-synucleinopathies

by myneuronews May 9, 2025

by myneuronews May 9, 2025

Perspective of Prodromal Individuals The perspective of individuals in the prodromal stage of α-synucleinopathies sheds …

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Functional neurological disorders
Electrophysiological characterisation of intranigral-grafted hiPSC-derived dopaminergic neurons in a mouse model of Parkinson’s disease

by myneuronews May 9, 2025

by myneuronews May 9, 2025

Electrophysiological Properties of hiPSC-Derived Neurons The study begins by examining the electrophysiological properties of human-induced …

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Functional neurological disorders
Memory processing by hippocampal adult-born neurons

by myneuronews May 9, 2025

by myneuronews May 9, 2025

Hippocampal Function and Adult Neurogenesis The hippocampus is a critical brain region known for its …

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Traumatic brain injury graphing: A case study of Charles Whitman
Research has identified violent behavior (i.e., assault, murder, and suicide) as a possible sequela of moderate to severe traumatic brain injury (TBI) and repeated mild TBI (rmTBI). However, misconceptions about consciousness and its ability to control an injured brain, the diverse spectrum of potential outcomes, and the role genetics/environmental factors can play make proving TBI's […]
Injury Prevention Programs in Youth Football: A Narrative Review of the FIFA 11+ and FUNBALL Programs
Football (soccer) is a dynamic sport popular among youth, but it poses risks of injuries such as ligament tears, fractures, and concussions. Injury prevention programs are essential for safeguarding young athletes' health and performance. This review evaluates two key programs: the 11+ and FUNBALL. The 11+ program is a structured warm-up designed for young female […]
Sensory driven neurophysiological mechanisms of concussion: a parsimonious and falsifiable theory
Every time a person sustains a blow to the head, they receive multiple atypical sensory inputs, often including pain. These directly stimulate the central nervous system. Yet, sensory input as a causal agent of neurophysiological dysfunction and post-concussion symptoms has never been explored. A new theory is proposed of sensory driven neurophysiological mechanisms of concussion […]
Inhibition of TRPM3 channels in the medial prefrontal cortex mitigates OCD symptoms following traumatic brain injury
Although tumor necrosis factor-alpha (TNF-α) plays an important role in the development of obsessive-compulsive disorder (OCD), the pathogenesis remains unclear. Since transient receptor potential melastatin 3 (TRPM3) channels are activated during inflammatory conditions, crosstalk with TNF-α in the progression of OCD has not been investigated yet. We hypothesize that mild traumatic brain injury (mTBI) stimulates […]
Age-Adjusted Cut-Off Values for Glial Fibrillary Acidic Protein and Ubiquitin Carboxy-Terminal Hydrolase L1 Improve the Diagnostic Accuracy of the Abbott Mild Traumatic Brain Injury Assay
Objectives: To establish age-adjusted cut-off values for glial fibrillary acidic protein (GFAP) and ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) and assess their impact on the diagnostic performance of the mild traumatic brain injury (mTBI) assay. Methods: The study included 175 adult mTBI patients presenting at the emergency department (ED) within 12 h from head trauma in […]