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treatment strategies

Functional neurological disorders
Deficits of Alzheimer’s Disease Neuropsychological Architecture Correlate with Specific Exosomal mRNA Expression: Evidence of a Continuum?

by myneuronews May 28, 2025

by myneuronews May 28, 2025

Neuropsychological Deficits in Alzheimer’s Disease Alzheimer’s disease (AD) is often characterized by a progressive decline …

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Functional neurological disorders
The Effects of Endoscopic Third Ventriculostomy Versus Ventriculoperitoneal Shunt on Neuropsychological and Motor Performance in Patients with Idiopathic Normal Pressure Hydrocephalus-ENVENTOR-iNPH: Study Protocol

by myneuronews May 28, 2025

by myneuronews May 28, 2025

Study Summary This study investigates the comparative effects of endoscopic third ventriculostomy (ETV) and ventriculoperitoneal …

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Functional neurological disorders
A practical guide to assessing functional motor weakness: a review of validated techniques

by myneuronews May 27, 2025

by myneuronews May 27, 2025

Understanding Functional Motor Weakness Functional motor weakness (FMW) is a condition where individuals experience significant …

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Functional neurological disorders
Phosphoribosylformylglycinamidine Synthase (PFAS) Deficiency: Clinical, Genetic and Metabolic Characterisation of a Novel Defect in Purine de Novo Synthesis

by myneuronews May 27, 2025

by myneuronews May 27, 2025

Clinical Presentation and Symptoms Phosphoribosylformylglycinamidine synthase (PFAS) deficiency presents a complex array of clinical symptoms …

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Headaches
Clinical Management and Outcomes of Dengue Fever and Enteric Fever

by myneuronews May 26, 2025

by myneuronews May 26, 2025

Clinical Characteristics of Dengue and Enteric Fever Dengue fever and enteric fever are two distinct …

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Stroke
Efficacy and Safety of Combined Catheter Ablation and Left Atrial Appendage Closure in Atrial Fibrillation: A Systematic Review and Meta-Analysis

by myneuronews May 26, 2025

by myneuronews May 26, 2025

Efficacy of Combined Interventions The investigation into the combined approach of catheter ablation and left …

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Traumatic brain injury
Letter: Comments on “Acupuncture Treatment for Chronic Post-Traumatic Headache in Individuals with Mild Traumatic Brain Injury: A Pilot Study”

by myneuronews May 26, 2025

by myneuronews May 26, 2025

Study Overview The pilot study recently explored the effectiveness of acupuncture as a therapeutic approach …

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Functional neurological disorders
Immune inflammatory regulation in Anti-NMDAR encephalitis: insights from transcriptome analysis

by myneuronews May 26, 2025

by myneuronews May 26, 2025

Immune Mechanisms in Anti-NMDAR Encephalitis Anti-NMDAR encephalitis is characterized by the presence of antibodies that …

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Traumatic brain injury
Mild and moderate traumatic brain injury: Screening, documentation and referral to concussion services

by myneuronews May 25, 2025

by myneuronews May 25, 2025

Understanding Mild and Moderate Traumatic Brain Injury Mild and moderate traumatic brain injuries (TBIs) represent …

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Functional neurological disorders
Penetrance of neurodevelopmental copy number variants is associated with variations in cortical morphology

by myneuronews May 25, 2025

by myneuronews May 25, 2025

Understanding Neurodevelopmental Copy Number Variants Neurodevelopmental copy number variants (CNVs) are structural alterations in the …

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Exo70 Protects Against Memory and Synaptic Impairments Following Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI), a leading cause of disability in young adults, often results from external forces that damage the brain. Cellularly, mTBI induces oxidative stress, characterized by excessive reactive oxygen species (ROS) and diminished antioxidant capacity. This redox imbalance disrupts hippocampal glutamatergic transmission and synaptic plasticity, where NMDA receptors (NMDARs) are crucial. The […]
Neurocognitive Outcomes After Extracranial Surgery and General Anesthesia in Patients with a History of Mild-to-Moderate Traumatic Brain Injury: Systemic Review and Meta-Analysis
Accelerated neurocognitive decline associated with surgeries under general anesthesia (GA), a phenomenon referred to as postoperative neurocognitive disorder (PND), is a significant public health concern. It not only poses inherent risks but may also contribute to the development of other neurodegenerative disorders. We systematically searched five databases for studies examining cognitive function in patients with […]
The Diagnostic and Prognostic Role of Biomarkers in Mild Traumatic Brain Injury: An Umbrella Meta-Analysis
CONCLUSIONS: The findings underscore the clinical promise of fluid biomarkers in the management of mTBI. S100B and GFAP are particularly valuable as screening and confirmatory markers, respectively. Nonetheless, further standardization of biomarker thresholds and additional longitudinal studies are necessary to validate the roles of UCH-L1, NfL, and Tau protein. The integration of these biomarkers into […]
Mechanisms Underlying Hyperexcitability: Combining Mossy Fiber Sprouting and Mossy Cell Loss in Neural Network Model of the Dentate Gyrus
Background/Objectives: A concussive head injury increases the likelihood of temporal lobe epilepsy through mechanisms that are not entirely understood. This study aimed to investigate how two key histopathological features shared by both TLE (temporal lobe epilepsy) and head injury-mossy fiber sprouting and hilar excitatory cell loss-contribute to the modulation of dentate gyrus excitability. Methods: A […]
Neurobiology of Chronic Pain, Posttraumatic Stress Disorder, and Mild Traumatic Brain Injury
CONCLUSIONS: Common therapeutic processes, such as focusing on sensitization, might be helpful for these conditions. As for causal mechanisms related to sensitization in the causality of psychological injuries, the major ones hypothesized relate to the biopsychosocial model, psychological control, and activation-inhibition coordination.