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treatment strategies

Functional neurological disorders
Transcranial magnetic stimulation as a primer for rapid improvement in functional neurological disorder: a case series

by myneuronews July 15, 2025

by myneuronews July 15, 2025

Background on Functional Neurological Disorder Functional Neurological Disorder (FND) is a condition characterized by neurological …

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Traumatic brain injury
Vulnerability factors for pediatric disorders of gut-brain interaction and implications for functional impairment

by myneuronews July 15, 2025

by myneuronews July 15, 2025

Vulnerability Factors Identification Identifying vulnerability factors for pediatric disorders of gut-brain interaction (GBI) requires a …

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Functional neurological disorders
Shared neural signatures in Functional Neurological Disorder and Chronic Pain: a multimodal narrative review

by myneuronews July 15, 2025

by myneuronews July 15, 2025

Neural Mechanisms in FND and Chronic Pain Research into the neural mechanisms underlying Functional Neurological …

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Functional neurological disorders
Identifying pyroptosis- and inflammation-related genes in spinal cord injury based on bioinformatics analysis

by myneuronews July 14, 2025

by myneuronews July 14, 2025

Gene Identification Methods To identify genes that play a role in pyroptosis and inflammation following …

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Functional neurological disorders
Immunological Correlation in Different Cutaneous Clinical Types of Lupus Erythematosus in the Bulgarian Population

by myneuronews July 14, 2025

by myneuronews July 14, 2025

Immunological Profile of Lupus Erythematosus The immunological profile of Lupus Erythematosus (LE) reveals a complex …

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Functional neurological disorders
A scoping review of studies on dissociative and conversion disorders in India

by myneuronews July 14, 2025

by myneuronews July 14, 2025

Overview of Dissociative and Conversion Disorders Dissociative and conversion disorders represent complex and often misunderstood …

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Functional neurological disorders
Extrapyramidal symptoms as early clinical predictors in first-episode schizophrenia and schizophreniform disorder: findings from the OPTiMiSE trial

by myneuronews July 13, 2025

by myneuronews July 13, 2025

Extrapyramidal Symptoms in First-Episode Schizophrenia Extrapyramidal symptoms (EPS) represent a group of movement disorders that …

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Traumatic brain injury
A one year longitudinal study of cortical myelination changes following pediatric mild traumatic brain injury

by myneuronews July 12, 2025

by myneuronews July 12, 2025

Cortical Myelination Changes Cortical myelination refers to the formation and maturation of myelin sheaths around …

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Functional neurological disorders
Role of ALOX5AP in the pathogenesis of cerebral small vessel disease: impact of inflammation and lipid metabolism dysregulation

by myneuronews July 12, 2025

by myneuronews July 12, 2025

Pathophysiological Mechanisms of ALOX5AP ALOX5AP (Arachidonate 5-Lipoxygenase-Activating Protein) plays a pivotal role in the pathophysiology …

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Traumatic brain injury
Integrative Constraint-Based Modeling and Proteomics Uncover Astrocytic Metabolic Adaptations to the Post-TBI Microenvironment

by myneuronews July 12, 2025

by myneuronews July 12, 2025

Study Overview The research explores the metabolic responses of astrocytes, a type of glial cell …

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Incretin Mimetics as Potential Therapeutics for Concussion and Traumatic Brain Injury: A Narrative Review
Traumatic brain injury (TBI) represents a significant health concern, with an estimated 70 million annual cases worldwide. Mild brain trauma (concussions) is the most common TBI (81%), followed by moderate (11%) and severe (8%). Cytokine release and neuroinflammation after TBI may cause blood-brain barrier and tissue damage, triggering unfavorable outcomes, including disabilities and mortality. Current […]
N-Stearidonoylethanolamine Restores CA1 Synaptic Integrity and Reduces Astrocytic Reactivity After Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI) disrupts hippocampal network function through coordinated alterations in glial reactivity, synaptic integrity, and adult neurogenesis. Effective therapeutic approaches targeting these interconnected processes remain limited. Lipid-derived molecules capable of modulating these mTBI-induced disturbances are emerging as promising neuroprotective candidates. Here, we investigated the effects of N-stearidonylethanolamine (SDEA), an ω-3 ethanolamide, in […]
Effects of persistent post-concussion symptoms on neurocognitive, motor, and neurophysiological outcomes
CONCLUSION: The PPCS group demonstrated greater symptom reporting and severity, worse neurocognitive performance, worse balance and gait performance, and altered neurophysiology. Further, females with PPCS demonstrated worse balance and gait performance compared to all other groups.
Injury-environment interaction: microglial priming by mTBI creates vulnerability to subsequent stress via the HMGB1-RAGE axis
CONCLUSION: Our study untangles a "priming-triggering" mechanism of injury-environment interaction, identifying the HMGB1-RAGE axis as its key molecular mediator. This finding not only enhances our understanding of how latent vulnerability transitions into overt neuropsychiatric disease, but also provides a promising target for preventive intervention.
Relationship between illness perceptions, coping style and post-concussion symptoms after systemic traumatic injury: A comparison of those with and without mild traumatic brain injury
Research has reported variable findings when investigating the relationship between outcome and coping style and illness perceptions after mild traumatic brain injury (mTBI). The present study investigated 138 individuals who had been admitted to hospital after suffering a traumatic systemic injury, with 91 of these individuals also fulfilling criteria for mTBI and 47 comprising a […]