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treatment strategies

Functional neurological disorders
Wogonin Inhibits Oxidative Stress in Hypoxia-Induced hCMEC/D3 Cells Through Suppressing CXCL8-Mediated TLR4/NF-κB Pathway

by myneuronews July 4, 2025

by myneuronews July 4, 2025

Mechanism of Wogonin Action Wogonin, a naturally occurring flavonoid derived from the plant Scutellaria baicalensis, …

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Functional neurological disorders
Wogonin Inhibits Oxidative Stress in Hypoxia-Induced hCMEC/D3 Cells Through Suppressing CXCL8-Mediated TLR4/NF-κB Pathway

by myneuronews July 4, 2025

by myneuronews July 4, 2025

Mechanisms of Wogonin in Oxidative Stress Wogonin, a naturally occurring flavonoid found in various plants, …

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Functional neurological disorders
Cortical macro- and microstructural changes in isolated rapid eye movement sleep behavior disorder

by myneuronews July 3, 2025

by myneuronews July 3, 2025

Cortical macrostructural alterations The study of cortical macrostructural alterations in individuals with isolated rapid eye …

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Functional neurological disorders
Biopsychosocial prognostic indicators in Functional Neurological Disorder: A systematic review

by myneuronews July 3, 2025

by myneuronews July 3, 2025

Prognostic Indicators in FND Functional Neurological Disorder (FND) presents a unique challenge in both diagnosis …

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Functional neurological disorders
Changes of functional brain network topology associated with nutritional indicator of patients with recurrent major depressive disorder

by myneuronews July 3, 2025

by myneuronews July 3, 2025

Functional Brain Network Changes Recent studies have highlighted intriguing transformations in the topology of functional …

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Functional neurological disorders
Quantum magnetization exchange through transient hydrogen bond matrix defines magnetic resonance signal relaxation and anisotropy in central nervous system

by myneuronews July 3, 2025

by myneuronews July 3, 2025

Magnetization Exchange Mechanisms The study explores the intricate processes involved in magnetization exchange mechanisms, which …

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Functional neurological disorders
Biopsychosocial prognostic indicators in Functional Neurological Disorder: A systematic review

by myneuronews July 3, 2025

by myneuronews July 3, 2025

Prognostic Factors in Functional Neurological Disorder Understanding the prognostic factors associated with Functional Neurological Disorder …

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Functional neurological disorders
Abnormal static and dynamic regional homogeneity in adolescent major depressive disorder with somatic symptoms: a resting-state fMRI study

by myneuronews July 3, 2025

by myneuronews July 3, 2025

Methodological Overview The study employs a resting-state functional magnetic resonance imaging (fMRI) approach to examine …

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Functional neurological disorders
Biopsychosocial prognostic indicators in Functional Neurological Disorder: A systematic review

by myneuronews July 3, 2025

by myneuronews July 3, 2025

Prognostic Indicators Overview The systematic review highlights various prognostic indicators that have emerged as significant …

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Traumatic brain injury
Plasma levels of biomarkers associated with vasodilation and neuroinflammation in pediatric patients with head trauma and their relationship with clinical characteristics of patients

by myneuronews July 3, 2025

by myneuronews July 3, 2025

Biomarkers of Vasodilation and Neuroinflammation In recent studies focusing on pediatric patients with head trauma, …

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Incretin Mimetics as Potential Therapeutics for Concussion and Traumatic Brain Injury: A Narrative Review
Traumatic brain injury (TBI) represents a significant health concern, with an estimated 70 million annual cases worldwide. Mild brain trauma (concussions) is the most common TBI (81%), followed by moderate (11%) and severe (8%). Cytokine release and neuroinflammation after TBI may cause blood-brain barrier and tissue damage, triggering unfavorable outcomes, including disabilities and mortality. Current […]
N-Stearidonoylethanolamine Restores CA1 Synaptic Integrity and Reduces Astrocytic Reactivity After Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI) disrupts hippocampal network function through coordinated alterations in glial reactivity, synaptic integrity, and adult neurogenesis. Effective therapeutic approaches targeting these interconnected processes remain limited. Lipid-derived molecules capable of modulating these mTBI-induced disturbances are emerging as promising neuroprotective candidates. Here, we investigated the effects of N-stearidonylethanolamine (SDEA), an ω-3 ethanolamide, in […]
Effects of persistent post-concussion symptoms on neurocognitive, motor, and neurophysiological outcomes
CONCLUSION: The PPCS group demonstrated greater symptom reporting and severity, worse neurocognitive performance, worse balance and gait performance, and altered neurophysiology. Further, females with PPCS demonstrated worse balance and gait performance compared to all other groups.
Injury-environment interaction: microglial priming by mTBI creates vulnerability to subsequent stress via the HMGB1-RAGE axis
CONCLUSION: Our study untangles a "priming-triggering" mechanism of injury-environment interaction, identifying the HMGB1-RAGE axis as its key molecular mediator. This finding not only enhances our understanding of how latent vulnerability transitions into overt neuropsychiatric disease, but also provides a promising target for preventive intervention.
Relationship between illness perceptions, coping style and post-concussion symptoms after systemic traumatic injury: A comparison of those with and without mild traumatic brain injury
Research has reported variable findings when investigating the relationship between outcome and coping style and illness perceptions after mild traumatic brain injury (mTBI). The present study investigated 138 individuals who had been admitted to hospital after suffering a traumatic systemic injury, with 91 of these individuals also fulfilling criteria for mTBI and 47 comprising a […]