Tag:

treatment

Functional neurological disorders
Insights into insulin signalling and oxidative stress in the Tg2576 mouse model of familial Alzheimer’s disease: effects of chronic oral galactose administration

by myneuronews June 16, 2025

by myneuronews June 16, 2025

Insulin Signalling Pathways in Alzheimer’s Disease Insulin signalling pathways play a crucial role in numerous …

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Functional neurological disorders
Insights into insulin signalling and oxidative stress in the Tg2576 mouse model of familial Alzheimer’s disease: effects of chronic oral galactose administration

by myneuronews June 16, 2025

by myneuronews June 16, 2025

Insulin Signalling Pathways in Alzheimer’s Disease The role of insulin signalling pathways in Alzheimer’s disease …

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Dementia
Retinal degeneration as an initial manifestation in a patient with neuronal intranuclear inclusion disease

by myneuronews June 14, 2025

by myneuronews June 14, 2025

Background of Retinal Degeneration Retinal degeneration encompasses a range of conditions characterized by the progressive …

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Traumatic brain injury
Tranexamic acid vs. embolization of the meningeal artery as an adjunctive therapeutic regime to reduce the recurrence rate after surgical relief of chronic subdural hematomas (TABASCO)-a randomized controlled trial

by myneuronews June 14, 2025

by myneuronews June 14, 2025

Study Overview The study aims to evaluate the effectiveness of tranexamic acid compared to embolization …

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Movement Disorders
Restless legs syndrome in pregnancy: A systematic review of prevalence

by myneuronews June 14, 2025

by myneuronews June 14, 2025

Prevalence of Restless Legs Syndrome Restless Legs Syndrome (RLS) during pregnancy is a condition that …

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Traumatic brain injury
The ecological validity of two novel non-immersive virtual reality tests of attention and executive functions in an mTBI population

by myneuronews June 14, 2025

by myneuronews June 14, 2025

Study Overview The investigation centered on assessing the ecological validity of two innovative non-immersive virtual …

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Headaches
Changes in metabolite profiles in the cerebrospinal fluid and in human neuronal cells upon tick-borne encephalitis virus infection

by myneuronews June 14, 2025

by myneuronews June 14, 2025

Metabolite Profile Changes Upon infection with the tick-borne encephalitis virus (TBEV), significant alterations occur in …

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Stroke
Tirzepatide, a dual GIP/GLP1-receptor co-agonist preserves cardiac function and improves survival in angiotensin II-induced heart failure model in mice: comparison to liraglutide

by myneuronews June 14, 2025

by myneuronews June 14, 2025

Study Overview The study aimed to investigate the effects of tirzepatide, a novel dual agonist …

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Functional neurological disorders
Brain-Specific Gata4 Downregulation in Greywick Female Mice Models the Metabolic Subtype of Polycystic Ovary Syndrome

by myneuronews June 14, 2025

by myneuronews June 14, 2025

Brain-Specific Gata4 Function in Metabolism Gata4 is a transcription factor known for its critical roles …

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Functional neurological disorders
Shared Genetic Networks in Schizophrenia and Bipolar Disorder: Hippocampal Volume-Mediated Neurobiological Mechanisms

by myneuronews June 13, 2025

by myneuronews June 13, 2025

Shared Genetic Mechanisms The investigation into the shared genetic mechanisms between schizophrenia and bipolar disorder …

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Exo70 Protects Against Memory and Synaptic Impairments Following Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI), a leading cause of disability in young adults, often results from external forces that damage the brain. Cellularly, mTBI induces oxidative stress, characterized by excessive reactive oxygen species (ROS) and diminished antioxidant capacity. This redox imbalance disrupts hippocampal glutamatergic transmission and synaptic plasticity, where NMDA receptors (NMDARs) are crucial. The […]
Neurocognitive Outcomes After Extracranial Surgery and General Anesthesia in Patients with a History of Mild-to-Moderate Traumatic Brain Injury: Systemic Review and Meta-Analysis
Accelerated neurocognitive decline associated with surgeries under general anesthesia (GA), a phenomenon referred to as postoperative neurocognitive disorder (PND), is a significant public health concern. It not only poses inherent risks but may also contribute to the development of other neurodegenerative disorders. We systematically searched five databases for studies examining cognitive function in patients with […]
The Diagnostic and Prognostic Role of Biomarkers in Mild Traumatic Brain Injury: An Umbrella Meta-Analysis
CONCLUSIONS: The findings underscore the clinical promise of fluid biomarkers in the management of mTBI. S100B and GFAP are particularly valuable as screening and confirmatory markers, respectively. Nonetheless, further standardization of biomarker thresholds and additional longitudinal studies are necessary to validate the roles of UCH-L1, NfL, and Tau protein. The integration of these biomarkers into […]
Mechanisms Underlying Hyperexcitability: Combining Mossy Fiber Sprouting and Mossy Cell Loss in Neural Network Model of the Dentate Gyrus
Background/Objectives: A concussive head injury increases the likelihood of temporal lobe epilepsy through mechanisms that are not entirely understood. This study aimed to investigate how two key histopathological features shared by both TLE (temporal lobe epilepsy) and head injury-mossy fiber sprouting and hilar excitatory cell loss-contribute to the modulation of dentate gyrus excitability. Methods: A […]
Neurobiology of Chronic Pain, Posttraumatic Stress Disorder, and Mild Traumatic Brain Injury
CONCLUSIONS: Common therapeutic processes, such as focusing on sensitization, might be helpful for these conditions. As for causal mechanisms related to sensitization in the causality of psychological injuries, the major ones hypothesized relate to the biopsychosocial model, psychological control, and activation-inhibition coordination.