Monthly Archives

June 2024

Traumatic brain injury
Understanding “Internal Fake News”: The Link Between Concussion, Sensory Alterations, and Emotional Health

by Ioannis Mavroudis June 29, 2024

by Ioannis Mavroudis June 29, 2024

Concussions and post-concussion symptoms significantly impact the brain’s ability to process and integrate sensory information, …

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Traumatic brain injury
Differentiating Between Concussion, Psychological Symptoms, and Malingering Using the ImPACT Test

by Ioannis Mavroudis June 25, 2024

by Ioannis Mavroudis June 25, 2024

The Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) is a vital tool in the assessment …

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Biomarkers Traumatic brain injury
Blood biomarkers in mTBI

by Ioannis Mavroudis June 22, 2024

by Ioannis Mavroudis June 22, 2024

Several studies have demonstrated that elevated levels of S100B, GFAP, UCH-L1, and NFL correlate with …

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Non-invasive vagus nerve stimulation is associated with the reduction in persistent post-concussion symptoms: an observational study
INTRODUCTION: Traumatic brain injury (TBI) remains a major public health challenge, with mild TBI (mTBI) frequently resulting in persistent cognitive, affective, and somatic symptoms. Non-invasive vagus nerve stimulation (nVNS) has demonstrated potential in reducing neuroinflammation and promoting recovery in preclinical TBI models. This retrospective, observational study assessed the impact of adjunctive nVNS on postconcussive symptoms […]
Spautin-1 alleviates depression-like behaviors in mice after traumatic brain injury by inhibiting MMP3 expression in microglia in the Hippocampal CA1 region
CONCLUSIONS: Spautin-1 alleviates depression-like behaviors in mice following mild TBI by inhibiting the MMP3 signaling pathway in microglia within the CA1 region of the hippocampus, indicating a potential therapeutic strategy for addressing post-TBI depression.
Concussive injuries induce neuronal stress-dependent tau mislocalization to dendritic spines with acrolein and functional network alteration in TBI-on-a-chip
Traumatic brain injuries (TBIs) are a risk factor for Alzheimer's disease (AD), and share several important pathological features including the development of neurofibrillary tangles (NFT) of tau protein. While this association is well established, the underlying pathogenesis is poorly defined and current treatment options remain limited, necessitating novel methods and approaches. In response we developed […]
Detecting mild traumatic brain injury with MEG scan data: One-vs-K-sample tests
Magnetoencephalography (MEG) scanner has been shown to be more accurate than other medical devices in detecting mild traumatic brain injury (mTBI). However, MEG scan data in certain spectrum ranges can be skewed, multimodal, and heterogeneous which can mislead the conventional case-control analysis that requires the data to be homogeneous and normally distributed within the control […]
Risk of Mortality Among Adult Females Diagnosed with Traumatic Brain Injury in an Academic Medical System
The objective of this retrospective cohort study was to evaluate mortality risk over five years among 6,432 female patients with a health care encounter diagnosis of TBI from hospitals and outpatient clinics within a university health system. We used TBI severity, defined by the Centers for Disease Control and Department of Defense/Veterans Affairs: mild, moderate/severe/penetrating, […]

June 2024

Understanding “Internal Fake News”: The Link Between Concussion, Sensory Alterations, and Emotional Health

Differentiating Between Concussion, Psychological Symptoms, and Malingering Using the ImPACT Test

Blood biomarkers in mTBI