Headaches

Lena Ohlsson August 1, 2019

Cephalalgia, Ahead of Print.
BackgroundCalcitonin gene-related peptide (CGRP) is a neuronal transmitter present in intracranial sensory nerves, where it is involved in migraine pathophysiology as well as other biological functions. Recently, the fully human monoclonal antibody erenumab (AMG 334), which targets the canonical calcitonin gene-related peptide receptor, showed significant prophylactic efficacy and favourable safety in phase II and III clinical trials for episodic and chronic migraine and is now approved for migraine prevention in several countries.ObjectiveGiven that calcitonin gene-related peptide can mediate vasodilation, we investigated the effect of erenumab on vasoactive responses in the presence or absence of various vasodilatory and vasocontractile mediators in a model using isolated human cerebral and meningeal arteries.MethodsRing segments of human isolated cerebral and meningeal arteries were mounted in a sensitive myograph.… Read More...

Miguel Glatstein, Yair Voliovitch, Rotem Orbach, Amit Carmi, Gil Amarilyo, Gary Carbell, Ayelet Rimon July 26, 2019

Background

Headache is a common complaint in children at a pediatric emergency department (PED). The primary objective of this analysis is to describe the outcome of patients presenting with headache to the PED and discharged with neurology follow up. The secondary objective is to describe the diagnostic evaluation children with headache underwent in the PED and to evaluate headache characteristics which are more likely associated with serious, life‐threatening conditions.… Read More...

Joan Crespi, Daniel Bratbak, David W. Dodick, Manjit Matharu, Kent Are Jamtøy, Erling Tronvik July 26, 2019

Background

The sphenopalatine ganglion (SPG) has previously been targeted in trigeminal neuralgia (TN), but its role in this condition has not been established.

Objective

To investigate the safety of injecting onabotulinumtoxinA (BTA) toward the SPG using the MultiGuide® in 10 patients with refractory classical TN, and collect preliminary efficacy data.… Read More...

Keyang Chen, Yungang Cao, Jianbin Wu, Haijie Xiang, Xiu‐Feng Huang, Bobei Chen July 26, 2019

Background and Objectives

Neurological manifestations associated with sphenoid sinus mucocele (SSM) are easily misdiagnosed due to nonspecific symptoms. The objective is to analyze and report the clinical features of SSM presenting with neurological manifestations, to allow an earlier diagnosis and more timely intervention for this disease.… Read More...

Vivian P Douglas July 26, 2019

Cephalalgia, Ahead of Print.
BackgroundOrbital myositis is an idiopathic, non-infectious condition, typically seen in young females and usually affecting one extraocular muscle. Orbital myositis mimicking cluster headache is a rare clinical entity, and this is the first description of a case of a secondary trigeminal autonomic cephalalgia from orbital myositis responsive to high-flow oxygen.CaseA young woman presented with new-onset, oxygen-responsive headache, periorbital pain and autonomic features.… Read More...

Jonathan H. Smith, Brian Mac Grory, Richard J. Butterfield, Babar Khokar, Bryce L. Falk, Lisa A. Marks July 25, 2019

Objectives

(1) To perform a systematic literature review to evaluate associations between post‐dural puncture headache (PDPH) and opening pressure (OP), closing pressure (CP), and volume of cerebrospinal fluid (V) removed. (2) To perform a case‐control study to evaluate pressure‐volume index (PVI) as a novel risk factor for PDPH.… Read More...

Anja S. Petersen, Mads C. J. Barloese, Agneta Snoer, Anne Mette S. Soerensen, Rigmor H. Jensen July 24, 2019

Objective

A evaluation of the effect of verapamil and other calcium channel blockers in cluster headache (CH) treatment and an investigation of possible effect mechanisms.

Background

Verapamil has been used in the prevention of CH for almost 3 decades, however, the mode of action and therapeutic target is still unknown.… Read More...

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