Stroke

Mehmet Akif Topcuoglu, Ethem Murat Arsava March 17, 2019

Background and Purpose: The routine use of percutaneous transcatheter patent foramen ovale closure (PPFOC) to prevent recurrent stroke in patients with cryptogenic stroke is still a matter of debate after completion major randomized controlled trials (RCTs). Methods: The fragility index of RCTs evaluating effect of PPFOC against medial therapy alone in stroke prevention was calculated to assess the robustness of statistically significant findings.… Read More...

Xingyu Chen, Zhaoji Liu, Jiayin Miao, Weihong Zheng, Qingwei Yang, Xiaowen Ye, Xiaorong Zhuang, Feng Peng March 17, 2019

Objective: The present study aimed to evaluate the association between stress hyperglycemia ratio (SHR) and outcome at 3 months after mechanical thrombectomy (MT) for acute occlusion in the anterior circulation. Methods: Data from 160 consecutive patients with large vessel occlusion in the anterior circulation who underwent MT from May 2013 to March 2018 were retrospectively reviewed.… Read More...

Emily B. Finn, Meredith J. Campbell Britton, Alana P. Rosenberg, John E. Sather, Evie G. Marcolini, Shelli L. Feder, Kevin N. Sheth, Charles C. Matouk, Laura T.L. Pham, Andrew S. Ulrich, Vivek L. Parwani, Beth Hodshon, Arjun K. Venkatesh March 16, 2019

Goal: Interhospital transfer (IHT) facilitates access to specialized neurocritical care but may also introduce unique risk. Our goal was to describe providers’ perceptions of safety threats during IHT for patients with nontraumatic intracranial hemorrhage. Materials and Methods: We employed qualitative, semi-structured interviews at an academic medical center receiving critically-ill neurologic transfers, and 5 referring hospitals.… Read More...

Ajay K. Mishra, Anu A. George, Kamal K. Sahu, Amos Lal, Cijoy K. Kuriakose March 16, 2019

We read with much pleasure the article “Lacunar Stroke in Cryptococcal Meningitis: Clinical and Radiographic Features” by Vela et al published in the Journal of Stroke and Cerebrovascular Disease.1 Authors have done a commendable job at describing the clinical and radiographical details of stroke in a cohort of patients with cryptococcal meningitis.… Read More...

Youngseok Kwak, Man Kyu Choi, Ki Hong Kim, Jae Hoon Cho March 15, 2019

Congenital absence of the common carotid artery without separate origin of internal carotid artery and external carotid artery from the aortic arch is a very rare anomaly. A persistent proatlantal intersegmental artery into adult life is also a rare condition. We report a patient with the coexistence of such rare conditions who presented with cerebral infarctions and intracranial aneurysms.… Read More...

Rouben A. Hovhannesyan, Iren G. Hovhannisyan March 15, 2019

Aim: Relative assessment and relationship between of platelet aggregation and the level of interleukins IL-1β, IL-4, IL-6, and IL-18 among ischemic stroke (IS) patients. Methods: A prospective clinical cohort study involved 108 IS patients, classified into group 1—surviving (93; 86.1%) and group 2—lethal outcomes (15; 13.9%).… Read More...

Xin-Wei He, Yan-Hui Shi, Rong Zhao, Yi-Sheng Liu, Ge-Fei Li, Yue Hu, Wei Chen, Guo-Hong Cui, Jing-Jing Su, Jian-Ren Liu March 15, 2019

Introduction: Multiple microRNAs (miRNAs) participate in the response to hypoxic/ischemic and ischemia-reperfusion events. However, the expression of these miRNAs in circulation from patients with acute ischemic stroke (AIS) receiving recanalization treatment has not been examined, and whether they are associated with the severity and outcome of stroke is still unknown.… Read More...

Haydn Hoffman, Robert Ziechmann, Amar Swarnkar, Hesham E. Masoud, Grahame Gould March 13, 2019

Introduction: There is continued interest in identifying factors that predict a favorable outcome after endovascular thrombectomy (EVT) for anterior circulation large vessel occlusion (ACLVO). We compared the predictive values of 2 different scoring systems for evaluating venous collateral circulation. Methods: A retrospective review of patients who underwent EVT for ACLVO at a single institution was performed.… Read More...

Richard Blythe, Azza Ismail, Aaizza Naqvi March 13, 2019

Intravenous recombinant tissue-plasminogen-activator (rtPA) and mechanical-thrombectomy (MT) are currently the only approved treatments for acute ischemic stroke. Their effectiveness was demonstrated in several clinical trials, and is therefore standard of care. Pregnant women were not included in these studies and consequently the effectiveness and safety in this group are unclear.… Read More...

Conor Judge, Sarah Ruttledge, Maria Costello, Robert Murphy, Elaine Loughlin, Alberto Alvarez-Iglesias, John Ferguson, Sarah Gorey, Aoife Nolan, Michelle Canavan, Martin O'Halloran, Martin J. O'Donnell March 13, 2019

Background: The association of lipid lowering therapy and intracerebral hemorrhage risk is controversial. Methods: We performed a cumulative meta-analysis of lipid lowering trials that reported intracerebral hemorrhage. Statin, fibrate, ezetimibe, PCSK9, and CETP trials were included. We explored whether the association of lipid lowering therapy and risk of intracerebral hemorrhage may vary by baseline low-density lipoprotein (LDL) level, mean change in LDL or baseline cardiovascular risk of population.… Read More...

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