Characterisation of Chronic Pain Syndrome in Patients With Functional Neurological Disorder

February 24, 2026

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Uncertainty as an operative construct and treatment target in functional neurological disorder
Understanding Uncertainty in FND Functional Neurological Disorder (FND) is characterized by neurological symptoms that are inconsistent with medical findings, leading to uncertainty both for patients and healthcare providers. This condition often manifests as loss of motor or sensory functions, such as tremors, seizures, or paralysis, which cannot be explained by structural neurological diseases. Patients frequently… Read more: Uncertainty as an operative construct and treatment target in functional neurological disorder
From marine predator to pharmacology: Conotoxin diversity, discovery, and therapeutic potential
Conotoxin Diversity and Classification Conotoxins are a remarkable group of bioactive peptides produced by cone snails, belonging to the family Conidae. These peptides are synthesized by the venom of these marine mollusks and exhibit an astonishing diversity in their structure and function, making them one of the most complex families of natural products known to… Read more: From marine predator to pharmacology: Conotoxin diversity, discovery, and therapeutic potential
Uncertainty as an operative construct and treatment target in functional neurological disorder
Uncertainty as a Construct In the context of functional neurological disorders (FND), uncertainty emerges as a powerful and multifaceted construct. It is recognized not merely as a feeling of doubt, but as a complex psychological phenomenon with profound implications for both patients and clinicians. Individuals suffering from FND often navigate a landscape rife with ambiguity… Read more: Uncertainty as an operative construct and treatment target in functional neurological disorder
Epidural cell therapy reduces neurological sequelae severity in canine distemper survivors
Study Overview The investigation into the therapeutic potential of epidural cell therapy for dogs that survived canine distemper virus (CDV) infection reveals a promising avenue for addressing the neurological complications that often arise from the disease. Canine distemper is a viral illness that can lead to severe neurological disorders, and many survivors experience long-lasting neurological… Read more: Epidural cell therapy reduces neurological sequelae severity in canine distemper survivors
N, N’-Dicyclohexyl-N-linoleic Acylurea, an Unsaturated Fatty Acid Derivative Alleviates Experimental Autoimmune Encephalomyelitis in C57BL/6 Mice
Study Overview The research investigates the effects of N, N’-Dicyclohexyl-N-linoleic acylurea, a compound designed from unsaturated fatty acids, on the progression of Experimental Autoimmune Encephalomyelitis (EAE) in C57BL/6 mice, a widely used model for studying multiple sclerosis (MS). This condition is characterized by the immune system attacking the central nervous system, leading to a variety… Read more: N, N’-Dicyclohexyl-N-linoleic Acylurea, an Unsaturated Fatty Acid Derivative Alleviates Experimental Autoimmune Encephalomyelitis in C57BL/6 Mice

Clinical significance of head CT scan in patients admitted to the emergency department with mild head trauma
Head computed tomography (CT) scan is the gold standard for early diagnosis of brain injuries in the Emergency Department (ED), but clinically important injuries after a mild head trauma (MHT) are rare. This study aims to evaluate the impact of head CTs on the management of patients presenting to the ED with MHT. In this […]
Traumatic Brain Injury Induces Senescence in Brain Microvasculature
CONCLUSION: These findings demonstrate differential γH2AX labelling of NVU components following TBI, suggesting that vulnerability to TBI-induced senescence can be specific both to the cell type and the time after the injury. This has implications on therapies targeting senescent cells for mitigating the long-term consequences of TBI.
Subconcussive Head Injuries Negatively Affect Academic Achievement in Adolescent Males
Background/Objectives: To determine the effects of a subconcussive head injury on adolescent student academic achievement assessed by grade point average (GPA). Methods: The study utilised an experimental (subconcussive head injury, n = 45) and a matched pair control group (n = 45). Data were collated at baseline (i.e., the term prior to sustaining a subconcussive […]
Endocrine Sequelae of Mild Traumatic Brain Injury in Patients Admitted to the Emergency Department: A 12-Month Study
Background/Objectives: Over the last two decades, there has been a substantial change in the understanding of post-traumatic hypopituitarism (PTHP), which is no longer regarded as a marginal phenomenon. Clinical manifestations of pituitary hormone deficiency are frequently nonspecific, with fatigue and cognitive dysfunction predominating. Given that head injuries currently constitute a global burden for healthcare systems, […]
Do Serum Brain Biomarkers Differentiate the Hemorrhagic Head Injury Lesion Phenotypes? An Interim Analysis of an On-Going Randomized Clinical Trial
Background: Traumatic head injury (THI) includes a diverse range of hemorrhagic brain lesions (HBL), which are distinct phenotypes with characteristic pathophysiological mechanisms. Computed tomography (CT) is the cornerstone of the initial assessment and diagnosis; however, its sensitivity is limited, especially in mild head injury. Blood-derived biomarkers, including Neuron-Specific Enolase (NSE) and S-100B, have been extensively […]

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