Tag:

Alzheimer’s disease

Dementia
Differential microglial responses to structurally distinct alpha-synuclein polymorphs

by myneuronews December 6, 2025

by myneuronews December 6, 2025

Differential Responses of Microglia Microglia, the resident immune cells of the central nervous system, exhibit …

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Dementia
Regional disparities of antidementia drug treatment in Germany: what can we learn for the new generation of Alzheimer’s therapies

by myneuronews December 4, 2025

by myneuronews December 4, 2025

Antidementia Drug Treatment Patterns Antidementia medications are primarily designed to manage symptoms associated with cognitive …

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Dementia
Assessing the health-related quality of life in informal caregivers of Alzheimer’s Disease: evidence from Malaysia

by myneuronews December 1, 2025

by myneuronews December 1, 2025

Health-Related Quality of Life in Caregivers The health-related quality of life (HRQoL) among informal caregivers …

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Traumatic brain injury
A Bioinformatic Study of Genetics Involved in Determining Mild Traumatic Brain Injury Severity and Recovery

by myneuronews November 27, 2025

by myneuronews November 27, 2025

Genetic Factors in Traumatic Brain Injury Traumatic brain injury (TBI) represents a significant public health …

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Dementia
Single-nucleus and spatial transcriptomic profiling of human temporal cortex and white matter reveals key associations with AD pathology

by myneuronews November 24, 2025

by myneuronews November 24, 2025

Study Overview This study centers on the intricate relationships between cellular profiles in the human …

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Dementia
The CSF Levels of Mitochondrial Phosphoenolpyruvate Carboxykinase 2 as a Novel Biomarker in Alzheimer’s Disease

by myneuronews November 19, 2025

by myneuronews November 19, 2025

Study Overview The research focuses on the role of mitochondrial phosphoenolpyruvate carboxykinase 2 (PEPCK-M) levels …

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Dementia
Dynamic functional connectivity and transcriptomic signatures reveal stage-dependent brain network dysfunction in Alzheimer’s disease spectrum

by myneuronews November 14, 2025

by myneuronews November 14, 2025

Study Overview The research focused on understanding the intricate relationship between brain network connectivity and …

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Dementia
Systematic post-translational modification genome wide identifies therapeutic targets for Alzheimer’s disease: evidence from multi-cohort analysis

by myneuronews October 30, 2025

by myneuronews October 30, 2025

Identifying Therapeutic Targets In recent years, identifying therapeutic targets for Alzheimer’s disease (AD) has gained …

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Traumatic brain injury
Bleeding Risk With Atrial Fibrillation, Prostate Cancer Screening, Alzheimer Disease, Concussion, Melanoma, Rheumatoid Arthritis

by myneuronews October 21, 2025

by myneuronews October 21, 2025

Bleeding Risk Assessment in Atrial Fibrillation Assessing the risk of bleeding in patients with atrial …

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Traumatic brain injury
Diagnostic and prognostic role of serum/plasma and CSF amyloid beta peptide levels in traumatic brain injury: a systematic review and meta-analysis

by myneuronews October 11, 2025

by myneuronews October 11, 2025

Background and Rationale Traumatic brain injury (TBI) represents a significant public health issue, with far-reaching …

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Clinical Cut Point for the Post Concussion Symptom Inventory Following Adolescent Concussion
CONCLUSIONS: Our results suggest a PCSI cut point of 23 can distinguish between adolescents with/without a recent concussion and may provide enhanced accuracy to identify a suspected concussion in the subacute time after injury.
Sex Differences in Severity and Recovery Following Mild Traumatic Brain Injury: A Systematic Review
Background: Sex-based variations in brain structure, hormonal balance, and neurochemistry may influence symptom presentation and recovery after mild traumatic brain injury (mTBI). This systematic review investigated sex-related differences in mTBI severity, symptoms, and recovery outcomes across different injury mechanisms. Methods: This review followed PRISMA 2020 guidelines and was registered with PROSPERO (CRD420251011379). Searches were conducted […]
Driving After Concussion: The Influence of Days Since Concussion on Simulated Driving Performance Recovery
CONCLUSIONS: Clinicians should consider recommendations that support limited driving during the acute stages (24-72 hours) of concussion followed by a gradual return to driving. A longitudinal study design in a larger sample is needed to better define driving performance recovery following concussion.
Non-Pharmacological Approaches to Addressing Overweight and Obesity in Children and Adolescents with Mental Illness: A Scoping Review of Quantitative and Qualitative Evidence
Children and adolescents with mental illness are at increased risk of developing overweight and obesity, a relationship that is complex, bidirectional, and often exacerbated by the weight-related side effects of psychotropic medications. This review addressed the research question: How are overweight and obesity addressed in children and adolescents with mental illness? Following JBI and PRISMA-ScR […]
A Prefrontal Neuromodulation Route for Post-Traumatic Olfactory Dysfunction: A Perspective Supported by Recovery During Left-DLPFC rTMS
Post-traumatic olfactory dysfunction (PTOD) is a common and often persistent sequela of mild traumatic brain injury (mTBI), with limited evidence-based treatment options. We propose that high-frequency rTMS applied to the left dorsolateral prefrontal cortex (DLPFC) may support olfactory recovery via top-down modulation of distributed olfactory, attentional, and reward networks, and we outline key mechanistic and […]