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Alzheimer’s disease

Dementia
Differential microglial responses to structurally distinct alpha-synuclein polymorphs

by myneuronews December 6, 2025

by myneuronews December 6, 2025

Differential Responses of Microglia Microglia, the resident immune cells of the central nervous system, exhibit …

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Dementia
Regional disparities of antidementia drug treatment in Germany: what can we learn for the new generation of Alzheimer’s therapies

by myneuronews December 4, 2025

by myneuronews December 4, 2025

Antidementia Drug Treatment Patterns Antidementia medications are primarily designed to manage symptoms associated with cognitive …

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Dementia
Assessing the health-related quality of life in informal caregivers of Alzheimer’s Disease: evidence from Malaysia

by myneuronews December 1, 2025

by myneuronews December 1, 2025

Health-Related Quality of Life in Caregivers The health-related quality of life (HRQoL) among informal caregivers …

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Traumatic brain injury
A Bioinformatic Study of Genetics Involved in Determining Mild Traumatic Brain Injury Severity and Recovery

by myneuronews November 27, 2025

by myneuronews November 27, 2025

Genetic Factors in Traumatic Brain Injury Traumatic brain injury (TBI) represents a significant public health …

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Dementia
Single-nucleus and spatial transcriptomic profiling of human temporal cortex and white matter reveals key associations with AD pathology

by myneuronews November 24, 2025

by myneuronews November 24, 2025

Study Overview This study centers on the intricate relationships between cellular profiles in the human …

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Dementia
The CSF Levels of Mitochondrial Phosphoenolpyruvate Carboxykinase 2 as a Novel Biomarker in Alzheimer’s Disease

by myneuronews November 19, 2025

by myneuronews November 19, 2025

Study Overview The research focuses on the role of mitochondrial phosphoenolpyruvate carboxykinase 2 (PEPCK-M) levels …

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Dementia
Dynamic functional connectivity and transcriptomic signatures reveal stage-dependent brain network dysfunction in Alzheimer’s disease spectrum

by myneuronews November 14, 2025

by myneuronews November 14, 2025

Study Overview The research focused on understanding the intricate relationship between brain network connectivity and …

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Dementia
Systematic post-translational modification genome wide identifies therapeutic targets for Alzheimer’s disease: evidence from multi-cohort analysis

by myneuronews October 30, 2025

by myneuronews October 30, 2025

Identifying Therapeutic Targets In recent years, identifying therapeutic targets for Alzheimer’s disease (AD) has gained …

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Traumatic brain injury
Bleeding Risk With Atrial Fibrillation, Prostate Cancer Screening, Alzheimer Disease, Concussion, Melanoma, Rheumatoid Arthritis

by myneuronews October 21, 2025

by myneuronews October 21, 2025

Bleeding Risk Assessment in Atrial Fibrillation Assessing the risk of bleeding in patients with atrial …

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Traumatic brain injury
Diagnostic and prognostic role of serum/plasma and CSF amyloid beta peptide levels in traumatic brain injury: a systematic review and meta-analysis

by myneuronews October 11, 2025

by myneuronews October 11, 2025

Background and Rationale Traumatic brain injury (TBI) represents a significant public health issue, with far-reaching …

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Educators' Perspectives of the Feasibility, Acceptability, and Appropriateness of the Buddy Program for Secondary School Students Post-Concussion
CONCLUSIONS: The Buddy Program aligns with school values and may be an avenue to support students returning to school following a concussion.
CTE neuropathology alone is associated with dementia and cognitive symptoms
INTRODUCTION: This studyexamined the independent contribution of chronic traumatic encephalopathy (CTE) neuropathology to symptoms.
Developing a Novel, Accessible Method for Estimating Cervical Muscle Volume in Adolescent Athletes
Magnetic resonance imaging is the current "gold standard" for measuring cervical muscle volume, but the associated time and cost may be prohibitive in numerous environments. This study sought to develop a novel and accessible model for estimating cervical muscle volume in adolescent athletes. It was hypothesized that cervical muscle volume could be accurately predicted using […]
Biomarker role in assessing imaging needs for mild cranial trauma (BRAIN-CT): study protocol for a single-center, randomized controlled trial
INTRODUCTION: Mild traumatic brain injury (mTBI) accounts for a significant proportion of emergency department (ED) visits, but current diagnostic protocols often lead to overuse of computed tomography (CT) imaging, despite low diagnostic yield. The BRAIN-CT trial evaluates the impact of rapid access to TBI biomarkers on decision-making for cranial imaging in patients with mTBI.
Spinal Cord Tau and Protein Copathologies Associated With Chronic Traumatic Encephalopathy
CONCLUSIONS AND RELEVANCE: This case-control study provides autopsy evidence of a high prevalence of complex spinal pathology in individuals with CTE-NC, supporting the concept of trauma-related encephalomyelopathy. The frequent co-occurrence of p-TDP-43, Aβ, and α-synuclein pathologies in individuals aged 65 years or older with CTE-NC suggests that cumulative trauma might contribute to widespread misfolded protein […]