Glial Heme Oxygenase-1 Regulates Neuroinflammation and Cerebrovascular Function After Mild Traumatic Brain Injury
Role of Heme Oxygenase-1 in Neuroinflammation Heme oxygenase-1 (HO-1) is an enzyme that plays a crucial role in the breakdown […]
Valsartan Repurposing to Mitigate Autoimmune Encephalomyelitis via ACE2/Ang1-7/MasR Axis Pathway Cognitive and Neuroinflammation Modulation; an Experimental and Chem-bio-informatics Study
Study Overview The research aimed at exploring the potential repurposing of valsartan, a medication primarily indicated for hypertension and heart
Loss of TREM2 is associated with altered microglial responses and inhibitory synaptic changes after closed head injury
Microglial Response Alterations The brain’s immune cells, known as microglia, play a crucial role in maintaining the health of the
PERK deficiency amplifies molecular, structural, and network vulnerability to repetitive mild traumatic brain injury
Molecular Mechanisms of PERK Deficiency The deficiency of Protein kinase-like endoplasmic reticulum kinase (PERK) fundamentally alters cellular functions, primarily through
Mesenchymal Stem Cell-Derived Small Extracellular Vesicles in Spinal Cord Injury: From Molecular Repair Mechanisms to Standardized Translational Development
Study Overview The research focuses on the potential of small extracellular vesicles (sEVs) derived from mesenchymal stem cells (MSCs) as
Cribriform plate microenvironment assembles a suppressive myeloid network during EAE-induced neuroinflammation
Microenvironment Characterization The cribriform plate, a structure located at the base of the skull, plays a significant role in the
Therapeutic Potential of Group 2 Innate Lymphoid Cells in Neuroinflammatory Diseases
Potential Mechanisms of Action Group 2 Innate Lymphoid Cells (ILC2s) play a crucial role in the immune response, particularly in
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Cholinergic regulation of neuroinflammation: linking microglia, immunometabolism, and neuromodulation
Cholinergic Signaling in Neuroinflammation Cholinergic signaling plays a pivotal role in neuroinflammation, an essential process where the nervous system responds
A convergence of global epidemics: diabetes as a modulator of neurodegenerative and neuro-inflammatory disorders
Impact of Diabetes on Neurodegenerative Disorders Diabetes has increasingly been recognized as a significant risk factor for neurodegenerative disorders, marking
Therapeutic potential of liver X receptor agonist GW3965 in preserving myelin integrity following traumatic brain injury
Study Overview This study investigates the potential therapeutic effects of GW3965, a liver X receptor (LXR) agonist, in the context