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astrocytes

Traumatic brain injury
Targeted complement inhibition ameliorates the pathological and cognitive outcomes in repetitive mild closed head injury

by myneuronews November 19, 2025

by myneuronews November 19, 2025

Study Overview The investigation into the effects of targeted complement inhibition on outcomes following repetitive …

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Dementia
Loss of C9orf72 impacts the peripheral neuromuscular system via immune dysregulation and accelerates the progression of amyotrophic lateral sclerosis in SOD-1 mutant mice

by myneuronews November 15, 2025

by myneuronews November 15, 2025

Impact of C9orf72 Loss on Neuromuscular Systems The loss of the C9orf72 gene has been …

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Traumatic brain injury
Metabolomics of cerebrospinal fluid following traumatic brain injury: Exploration of biomarkers for secondary injuries and severity

by myneuronews November 14, 2025

by myneuronews November 14, 2025

Biomarkers in cerebrospinal fluid analysis Cerebrospinal fluid (CSF) serves as a crucial medium for assessing …

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Traumatic brain injury
Therapeutic VEGFC treatment provides protection against traumatic-brain-injury-driven tauopathy pathogenesis

by myneuronews November 8, 2025

by myneuronews November 8, 2025

Therapeutic Efficacy of VEGFC The treatment of traumatic brain injury (TBI) has been a significant …

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Traumatic brain injury
Evolution of Axonal Injury in the Closed Head Impact Model of Engineered Rotational Acceleration in Adult Ferrets

by myneuronews October 30, 2025

by myneuronews October 30, 2025

Study Overview This research investigates the progression of axonal injury resulting from a model of …

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Traumatic brain injury
AQP4 in cerebrospinal fluid correlates with severity and prognosis in moderate to severe traumatic brain injury

by myneuronews October 25, 2025

by myneuronews October 25, 2025

Background and Rationale Traumatic brain injury (TBI) is a significant public health concern, often resulting …

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Traumatic brain injury
Association of Preinjury Beta-Blocker Exposure With Brain Injury Biomarkers Following Traumatic Brain Injury

by myneuronews September 30, 2025

by myneuronews September 30, 2025

Study Overview This study investigates the connection between preinjury exposure to beta-blockers and the levels …

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Traumatic brain injury
CD300f enables microglial damage sensing, efferocytosis, and apoptotic cell metabolization after brain injury

by myneuronews September 11, 2025

by myneuronews September 11, 2025

Microglial Function in Brain Injury Microglia, the primary immune cells of the central nervous system, …

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Headaches
State-of-the-art preclinical techniques to study the impact of spreading depolarizations in awake rodents

by myneuronews August 29, 2025

by myneuronews August 29, 2025

Overview of Spreading Depolarizations Spreading depolarizations (SDs) refer to a wave of electrical activity that …

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Traumatic brain injury
Blood Biomarkers as Optimization Tools for Computed Tomography in Mild Traumatic Brain Injury Management in Emergency Departments: A Systematic Review

by myneuronews August 27, 2025

by myneuronews August 27, 2025

Blood Biomarkers and Their Role Blood biomarkers are measurable substances in the blood that can …

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Study of ubiquitin C-terminal hydrolase-L1, glial fibrillary acidic protein, and interleukin-6 levels in an experimental head trauma model in rabbits
CONCLUSION: Serum UCH-L1 differentiated moderate and severe trauma from controls in a rabbit model, whereas CSF GFAP and IL-6 levels reflected severe injury. Validation in larger preclinical and clinical studies is warranted.
Correlation of Optic Nerve Sheath Diameter With Severity and Outcome in Head Injury: Ultrasonographic and CT Evaluation
Objective This study aimed to determine the extent to which ultrasonographic and computed tomographic (CT) measurements of the optic nerve sheath diameter (ONSD) correlate with the prognosis and severity of traumatic brain injury (TBI). Methodology A prospective cohort study was conducted among 200 adult patients admitted to a Level 1 trauma center over one year. […]
Admission blood glucose and neutrophil-to-lymphocyte ratio for differentiating CT-positive from CT-negative mild traumatic brain injury
This study aimed to assess the diagnostic utility of routine laboratory biomarkers in adults with mTBI. We conducted a prospective study of patients who were admitted to the neurosurgical department with mTBI, had admission laboratory data available, and a brain CT scan was performed. The cohort included 101 patients (mean age: 59 ± 23.14 years). […]
Bidirectional Relationship Between Mental Health and Sports Injury in Adolescents: A Systematic Review and Meta-analysis
CONCLUSIONS: We found evidence for a bidirectional relationship between sports injuries and mental health in adolescent athletes. Further research is needed to elucidate the mechanisms underlying this relationship. Early interventions focusing on supporting mental health after sports injury, and addressing pre-existing mental health issues to reduce the risk of subsequent injury, should be tailored towards […]
Does Timing of Concussion in Season Affect Incidence and Recovery in Division I Collegiate Football Players? A CARE Consortium Study
CONCLUSIONS: In a multi-institution cohort of collegiate football players, preseason resulted in the highest incidence of concussions, while early and late-season concussions had significantly longer time to SR compared to preseason. These temporal patterns suggest that contextual factors may influence concussion outcomes and warrant mechanistic investigation to inform future management strategies.