Roles of Metformin and Pioglitazone in Regulating A1-like Astrocyte Activation in EAE Mice
Study Overview This investigation centers on the roles of two pharmacological agents, Metformin and Pioglitazone, in modulating the activation state […]
Purkinje cell-specific loss of Neurofascin and Ankyrin G causes disruption of axon initial segments, neurodegeneration, and cerebellar ataxia
Pathophysiological Mechanisms The pathophysiology underlying Purkinje cell-specific disruptions in neurofascin and ankyrin G reveals critical insights into the mechanisms that
Microglial PD-1/PD-L1 axis in CNS demyelinating diseases: a dual immunoregulatory perspective
Microglial Function in CNS Demyelination Microglia are specialized immune cells residing in the central nervous system (CNS) and play a
Investigation of quantitative structural changes in astrocyte cells after laser-induced shockwave
Study Overview The research investigates the effects of laser-induced shockwaves on the structural properties of astrocyte cells, which are pivotal
Emerging CSF and Serum Biomarkers in Multiple Sclerosis: Cytokines, MOG, GFAP, and Beyond
Emerging Biomarkers in MS Recent advancements in the understanding of multiple sclerosis (MS) have led to the identification of new
Emerging CSF and Serum Biomarkers in Multiple Sclerosis: Cytokines, MOG, GFAP, and Beyond
Biomarker Significance in Multiple Sclerosis Biomarkers are critical in enhancing our understanding of multiple sclerosis (MS), a complex neurological disorder
Repetitive trans-spinal magnetic stimulation promotes repair in inflammatory spinal cord injury through sex-dependent immune modulation
Study Overview The present investigation centers on the effects of repetitive trans-spinal magnetic stimulation (rTMS) on spinal cord injury (SCI),
PPARγ activation by leriglitazone counteracts neurodegeneration and neuroinflammation in a disease-relevant mouse model of COASY dysfunction
Study Overview The research focuses on the therapeutic effects of leriglitazone, a PPARγ (peroxisome proliferator-activated receptor gamma) agonist, in a
The Crossroads of Neuroinflammation and Biomarkers in Multiple Sclerosis: A Systematic Review
Neuroinflammation Mechanisms Neuroinflammation is a complex biological response characterized by the activation of the immune system within the central nervous
Mechanisms underlying DEHP/MEHP-induced toxicity in multiple sclerosis: An integrated analysis combining network toxicology, bioinformatics, and in vivo experimental validation
Mechanisms of DEHP/MEHP Toxicity Di(2-ethylhexyl) phthalate (DEHP) and its primary metabolite, mono(2-ethylhexyl) phthalate (MEHP), are environmental pollutants commonly found in