Tag:

biomarkers

Traumatic brain injury
Neurobiomarkers for Traumatic Brain Injury: Comparison of Serum Values Within 24 Hours of Injury With Glasgow Coma Scale (GCS) Scores in a Prospective Cohort Trial

by myneuronews July 2, 2025

by myneuronews July 2, 2025

Neurobiomarkers in Traumatic Brain Injury Neurobiomarkers represent measurable indicators located in the body, which provide …

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Functional neurological disorders
Structural insights into heterohexameric assembly of epilepsy-related ligand-receptor complex LGI1-ADAM22

by myneuronews July 2, 2025

by myneuronews July 2, 2025

Structural Characterization of LGI1-ADAM22 Complex The LGI1-ADAM22 complex plays a pivotal role in the synaptic …

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Functional neurological disorders
Development of a novel liquid chromatography-tandem mass spectrometry based enzymatic assay of 5,10-methylenetetrahydrofolate reductase

by myneuronews July 2, 2025

by myneuronews July 2, 2025

Enzymatic Assay Development The development of a novel enzymatic assay for 5,10-methylenetetrahydrofolate reductase (MTHFR) taps …

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Traumatic brain injury
Biomarker evidence of neurodegeneration in mid-life former rugby players

by myneuronews July 2, 2025

by myneuronews July 2, 2025

Neurodegeneration Biomarkers Biomarkers indicative of neurodegeneration are crucial for understanding the underlying processes affecting brain …

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Traumatic brain injury
Brain health concerns in former rugby players: clinical and cognitive phenotypes

by myneuronews July 2, 2025

by myneuronews July 2, 2025

Context of Brain Health in Rugby The discussion around brain health in former rugby players …

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Traumatic brain injury
The chronic aftermath of recurrent intimate partner violence-related brain injuries: Insights from rat models of traumatic brain injury and non-fatal strangulation

by myneuronews July 2, 2025

by myneuronews July 2, 2025

Research Framework The exploration of recurrent intimate partner violence (IPV) and its effects on brain …

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Traumatic brain injury
Pediatric Mild Traumatic Brain Injury and Concussion

by myneuronews June 28, 2025

by myneuronews June 28, 2025

Understanding Mild Traumatic Brain Injury in Pediatric Patients Pediatric mild traumatic brain injury (mTBI), commonly …

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Dementia
Depression exacerbates AD pathology through lactate-dependent activation of microglial Kv1.3 to promote Aβ-containing exosome spreading

by myneuronews June 27, 2025

by myneuronews June 27, 2025

Background and Rationale The intersection of depression and Alzheimer’s disease (AD) has garnered increasing attention …

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Functional neurological disorders
Clinically Accurate Diagnosis of Alzheimer’s Disease via Single-Molecule Bioelectronic Label-Free Profiling of Multiple Blood Extracellular Vesicle Biomarkers

by myneuronews June 27, 2025

by myneuronews June 27, 2025

Clinical Relevance of Biomarkers The study underscores the pivotal role of biomarkers in the clinical …

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Traumatic brain injury
Distinct clinical phenotypes and their neuroanatomic correlates in chronic traumatic brain injury

by myneuronews June 27, 2025

by myneuronews June 27, 2025

Clinical Phenotypes In chronic traumatic brain injury (TBI), individuals often manifest a variety of clinical …

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An Aggressive Juvenile Nasopharyngeal Angiofibroma With Intracranial and Orbital Extension in an Adolescent Female: A Case Report and Focused Literature Review
Case Presentation We present the case of a 15-year-old female patient who exhibited clinical signs…
Maintenance of neuronal TDP-43 expression requires axonal lysosome transport
Study Overview The investigation centered on understanding the critical role of TDP-43, a protein associated…
Personality Profiles Among People With Functional Motor Disorders
Personality Traits in Functional Motor Disorders Research has established a nuanced understanding of the personality…
Increased Prevalence of an Oxytocin Receptor Gene Variant in Functional Neurological Disorder: A Case-Control Study
Background and Rationale Functional Neurological Disorder (FND) presents a unique challenge within the realm of…
Conversion Disorder With Mutism as the Presenting Symptom
Understanding Conversion Disorder Conversion disorder, also known as Functional Neurological Disorder (FND), manifests through neurological…

Hyperbaric oxygen therapy improves post-concussion symptoms in adults with childhood traumatic brain injury: a retrospective cohort study
Post-concussion syndrome (PCS) following childhood traumatic brain injury (TBI) can result in persistent cognitive impairments that extend into adulthood, yet it remains significantly underdiagnosed and undertreated. This study evaluated the effects of hyperbaric oxygen therapy (HBOT) on chronic neurocognitive symptoms in adults with PCS stemming from pediatric TBI. We conducted a retrospective analysis of patients […]
A Case of Extensive Pneumocephalus Following an Electric Scooter Accident
The use of electric scooters (e-scooters) has rapidly increased in Japan, accompanied by a rise in associated injuries. Severe head trauma can occur even when the Glasgow Coma Scale score suggests a mild injury, particularly when major clinical signs are present. Therefore, careful observation and appropriate management are essential. A 42-year-old woman injured by an […]
The cumulative effects of a collegiate athletic career on general health measures: findings from the CARE Consortium
CONCLUSIONS: Lifetime concussion history is associated with self-reported health outcomes at institutional-exit, though small effect sizes suggest limited clinical consequence. Higher contact-exposure sports and increased YoP were associated with improved scores on some clinical measures. Further longitudinal monitoring is encouraged to evaluate health-related changes over time, to support student-athletes as they transition out of collegiate […]
Efficacy of Methylphenidate in Patients With Brain Disease: A Systematic Review and Meta-Analysis
This systematic review and meta-analysis evaluated the efficacy and safety of methylphenidate in patients with brain disease. A comprehensive search up to November 4, 2024 identified 33 randomized controlled trials involving 1,369 participants with traumatic brain injury (TBI), stroke, Parkinson's disease (PD), Alzheimer's disease (AD), other dementias, and multiple sclerosis. Methylphenidate was administered at 10-80 […]
Symptoms of Allodynia and Pain Thresholds Amongst Those with Acute Post-Traumatic Headache Attributed to Mild Traumatic Brain Injury: A Prospective, Longitudinal Study
Background Post-traumatic headache (PTH) is a common acute and persistent symptom following mild traumatic brain injury (mTBI). Symptoms of cutaneous allodynia and presence of nociceptive sensitization might be associated with acute PTH and its persistence. The objectives of this study were to compare allodynia symptoms and cutaneous heat pain thresholds amongst males and females with […]