Tag:

blood-brain barrier

Traumatic brain injury
Widespread and cell-type-specific transcriptomic reorganization following mild traumatic brain injury

by myneuronews June 6, 2025

by myneuronews June 6, 2025

Transcriptomic Changes Induced by Injury Mild traumatic brain injury (mTBI) triggers significant changes in the …

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Traumatic brain injury
Erratum: Modified Mouse Model of Repetitive Mild Traumatic Brain Injury Incorporating Thinned-Skull Window and Fluid Percussion

by myneuronews June 4, 2025

by myneuronews June 4, 2025

Study Overview The research presented focuses on the development and validation of an advanced animal …

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Traumatic brain injury
Sex-dependent blood-brain barrier alterations following repeated mild blast traumatic brain injury at varying inter-injury intervals

by myneuronews June 1, 2025

by myneuronews June 1, 2025

Study Overview The investigation focused on the impact of repeated mild blast traumatic brain injuries …

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Functional neurological disorders
Fully biodegradable dendrimers as novel nanodrugs for amyloid-β-induced neurotoxicity

by myneuronews May 23, 2025

by myneuronews May 23, 2025

Biodegradable Dendrimers: A Novel Approach Dendrimers are highly branched molecules that can be customized at …

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Traumatic brain injury
Genome-wide analysis of lncRNA m6A methylation in the mouse cortex after repetitive mild traumatic brain injury

by myneuronews May 20, 2025

by myneuronews May 20, 2025

Background on lncRNA and m6A Methylation Long non-coding RNAs (lncRNAs) are an intriguing class of …

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Functional neurological disorders
Changes in brain functional connectivity and clinical correlations in neuromyelitis optica spectrum disorder: a longitudinal resting-state fMRI study

by myneuronews May 20, 2025

by myneuronews May 20, 2025

Overview of Neuromyelitis Optica Spectrum Disorder Neuromyelitis Optica Spectrum Disorder (NMOSD) is a rare, autoimmune …

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Traumatic brain injury
Imaging a concussion and the ensuing immune response at the blood-brain barrier

by myneuronews May 19, 2025

by myneuronews May 19, 2025

Understanding the Blood-Brain Barrier The blood-brain barrier (BBB) is a highly selective permeability barrier that …

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Functional neurological disorders
S100B Mitigates Cytoskeletal and Mitochondrial Alterations in a Glial Cell Model of Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay

by myneuronews May 19, 2025

by myneuronews May 19, 2025

Pathophysiology of Autosomal Recessive Spastic Ataxia Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS) is characterized …

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Headaches
Neurological complications of orthopoxvirus infections: neurotropism and neurovirulence

by myneuronews May 15, 2025

by myneuronews May 15, 2025

Neurological Manifestations in Orthopoxvirus Infection Orthopoxvirus infections are associated with a variety of neurological manifestations …

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Dementia
Intranasal Delivery of BACE1 siRNA and Berberine via Engineered Stem Cell Exosomes for the Treatment of Alzheimer’s Disease

by myneuronews May 12, 2025

by myneuronews May 12, 2025

Treatment Strategy Overview In recent years, the exploration of innovative approaches to treat Alzheimer’s disease …

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Interventional Treatment Strategies for Headache and Facial Pain
Interventional Techniques and Approaches Interventional techniques for managing headache and facial pain involve various procedures…
Systematic post-translational modification genome wide identifies therapeutic targets for Alzheimer’s disease: evidence from multi-cohort analysis
Identifying Therapeutic Targets In recent years, identifying therapeutic targets for Alzheimer’s disease (AD) has gained…
Functional Connectivity Gradients Reveal Altered Hierarchical Cortical Organization in Functional Neurological Disorder
Functional Connectivity Analysis Functional connectivity analysis has emerged as a pivotal method for understanding how…
An Intervention to Improve Emotion Regulation in Individuals With Traumatic Brain Injury: A Randomized Controlled Trial
Study Overview This research focused on assessing the effectiveness of a targeted intervention aimed at…
Evolution of Axonal Injury in the Closed Head Impact Model of Engineered Rotational Acceleration in Adult Ferrets
Study Overview This research examines the impact of engineered rotational acceleration on axonal injury in…

SaVeBRAIN.Kids-study protocol for a cluster-randomized stepped-wedge trial to reduce hospitalizations for mild traumatic brain injury in children in Germany
BACKGROUND: Traumatic brain injury (TBI) is one of the most important pediatric conditions worldwide. In Germany, hospitalization rates for mild TBI drastically exceed hospitalization rates from similar healthcare systems.
A Modified Repetitive Closed Head Injury Model Inducing Persistent Neuroinflammation and Functional Deficits Without Extensive Cortical Tissue Destruction
Traumatic brain injury (TBI) remains a significant clinical challenge, with limited treatment options and long-term neurological impairments. Mild to moderate TBI represents the most common form, making it a critical therapeutic target. However, current animal models poorly reflect human TBI pathophysiology, necessitating improved preclinical paradigms. Here, we present a refined repetitive closed head injury (rCHI) […]
Traumatic Microbleeds in Mild Traumatic Brain Injury: Stability, Distribution, and Association with Other Injuries
This study aimed to investigate whether the amount of traumatic microbleeds (TMBs) detected on magnetic resonance imaging (MRI) changes in different brain regions after a 3-month follow-up in adult patients with mild traumatic brain injury (mTBI). A 3 T MRI of the brain was conducted at baseline (3-17 days after trauma) and at 3 months […]
An Intervention to Improve Emotion Regulation in Individuals With Traumatic Brain Injury: A Randomized Controlled Trial
CONCLUSIONS: Evidence supports the efficacy of Online EmReg to improve ER following TBI.
Evolution of Axonal Injury in the Closed Head Impact Model of Engineered Rotational Acceleration in Adult Ferrets
Concussion-related symptoms, such as impaired balance, slower processing speed, attention deficits, memory dysfunction, and irritability, are thought to result from diffuse axonal injury (DAI), characterized by selective damage to white matter axons. Axons subjected to this mechanical stretch injury exhibit diverse pathological changes, including disruption of axonal transport, neurofilament compaction and degradation, myelin sheath disruption, […]