Tag:

genetic predisposition

Dementia
Discrepancies between CSF biomarker and PET determinations of elevated brain amyloid and their prognostic significance

by myneuronews July 9, 2025

by myneuronews July 9, 2025

Study Overview The ongoing challenge of accurately diagnosing Alzheimer’s disease and other neurodegenerative conditions has …

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Functional neurological disorders
A comparative study on growth, feed intake, and serum vitamin and mineral concentrations in Western white-faced rams with and without limb deformities

by myneuronews July 3, 2025

by myneuronews July 3, 2025

Growth and Feed Intake Comparison The study focused on the growth rates and feed intake …

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Functional neurological disorders
Identification of comorbid genes between type 2 diabetes and migraine through peripheral blood single-cell and Mendelian randomization analysis

by myneuronews July 2, 2025

by myneuronews July 2, 2025

Comorbid Gene Identification The identification of comorbid genes linking type 2 diabetes and migraine is …

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Dementia
Knowledge and attitudes towards Alzheimer’s disease among adult residents in Jiulongpo, Chongqing, China: A cross-sectional survey

by myneuronews June 30, 2025

by myneuronews June 30, 2025

Study Overview This research aimed to explore the awareness and perceptions regarding Alzheimer’s disease among …

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Dementia
Uncovering Putative Causal Non-Coding RNAs in Acute and Chronic Myeloid Leukemia: A Genome-Wide Mendelian Randomization Study

by myneuronews June 27, 2025

by myneuronews June 27, 2025

Study Overview The investigation aimed to explore the role of non-coding RNAs in the development …

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Functional neurological disorders
Circulating inflammatory proteins as pathogenic mediators and potential therapeutic targets in myasthenia gravis

by myneuronews June 26, 2025

by myneuronews June 26, 2025

Pathogenesis of Myasthenia Gravis Myasthenia Gravis (MG) is an autoimmune disorder characterized by weakness and …

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Functional neurological disorders
Dynamic electro-clinical features in Guanidinoacetate N-methyltransferase deficiency: A familial case series

by myneuronews June 21, 2025

by myneuronews June 21, 2025

Clinical Presentation and Genetic Findings The study highlights the varied clinical presentations associated with Guanidinoacetate …

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Traumatic brain injury
Resting-State Brain Activity Changes and Their Genetic Correlates in Mild Traumatic Brain Injury

by myneuronews June 13, 2025

by myneuronews June 13, 2025

Study Overview The investigation into resting-state brain activity alterations in individuals who have experienced mild …

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Functional neurological disorders
Seizures and Functional Deficits across Mendelian Disorders of Epigenetic Machinery: Differential Effects as a Function of Epigenetic Modifications

by myneuronews June 13, 2025

by myneuronews June 13, 2025

Understanding Mendelian Disorders Mendelian disorders are genetic conditions resulting from mutations in a single gene …

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Traumatic brain injury
Protocol of a randomized, single-blind, controlled trial of an 18-month, home-based, high-intensity, exercise intervention in older, cognitively unimpaired APOE ε4 carriers

by myneuronews June 11, 2025

by myneuronews June 11, 2025

Study Overview This trial is meticulously designed to assess the effectiveness of a high-intensity, home-based …

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Interventional Treatment Strategies for Headache and Facial Pain
Interventional Techniques and Approaches Interventional techniques for managing headache and facial pain involve various procedures…
Systematic post-translational modification genome wide identifies therapeutic targets for Alzheimer’s disease: evidence from multi-cohort analysis
Identifying Therapeutic Targets In recent years, identifying therapeutic targets for Alzheimer’s disease (AD) has gained…
Functional Connectivity Gradients Reveal Altered Hierarchical Cortical Organization in Functional Neurological Disorder
Functional Connectivity Analysis Functional connectivity analysis has emerged as a pivotal method for understanding how…
An Intervention to Improve Emotion Regulation in Individuals With Traumatic Brain Injury: A Randomized Controlled Trial
Study Overview This research focused on assessing the effectiveness of a targeted intervention aimed at…
Evolution of Axonal Injury in the Closed Head Impact Model of Engineered Rotational Acceleration in Adult Ferrets
Study Overview This research examines the impact of engineered rotational acceleration on axonal injury in…

SaVeBRAIN.Kids-study protocol for a cluster-randomized stepped-wedge trial to reduce hospitalizations for mild traumatic brain injury in children in Germany
BACKGROUND: Traumatic brain injury (TBI) is one of the most important pediatric conditions worldwide. In Germany, hospitalization rates for mild TBI drastically exceed hospitalization rates from similar healthcare systems.
A Modified Repetitive Closed Head Injury Model Inducing Persistent Neuroinflammation and Functional Deficits Without Extensive Cortical Tissue Destruction
Traumatic brain injury (TBI) remains a significant clinical challenge, with limited treatment options and long-term neurological impairments. Mild to moderate TBI represents the most common form, making it a critical therapeutic target. However, current animal models poorly reflect human TBI pathophysiology, necessitating improved preclinical paradigms. Here, we present a refined repetitive closed head injury (rCHI) […]
Traumatic Microbleeds in Mild Traumatic Brain Injury: Stability, Distribution, and Association with Other Injuries
This study aimed to investigate whether the amount of traumatic microbleeds (TMBs) detected on magnetic resonance imaging (MRI) changes in different brain regions after a 3-month follow-up in adult patients with mild traumatic brain injury (mTBI). A 3 T MRI of the brain was conducted at baseline (3-17 days after trauma) and at 3 months […]
An Intervention to Improve Emotion Regulation in Individuals With Traumatic Brain Injury: A Randomized Controlled Trial
CONCLUSIONS: Evidence supports the efficacy of Online EmReg to improve ER following TBI.
Evolution of Axonal Injury in the Closed Head Impact Model of Engineered Rotational Acceleration in Adult Ferrets
Concussion-related symptoms, such as impaired balance, slower processing speed, attention deficits, memory dysfunction, and irritability, are thought to result from diffuse axonal injury (DAI), characterized by selective damage to white matter axons. Axons subjected to this mechanical stretch injury exhibit diverse pathological changes, including disruption of axonal transport, neurofilament compaction and degradation, myelin sheath disruption, […]