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headaches

Headaches
Sildenafil provokes headache but not migraine in men with migraine without aura: a randomized, placebo-controlled crossover trial

by myneuronews January 10, 2026

by myneuronews January 10, 2026

Study Overview The research aimed to investigate the effects of sildenafil, a phosphodiesterase type 5 …

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Traumatic brain injury
Mechanisms and products implicated in mild traumatic brain injury among children aged 0-5 years old presenting to Canadian emergency departments

by myneuronews January 9, 2026

by myneuronews January 9, 2026

Mechanisms of Mild Traumatic Brain Injury Mild traumatic brain injury (mTBI) occurs when a child’s …

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Traumatic brain injury
IV dexamethasone as adjuvant therapy to metoclopramide for acute posttraumatic headache in the ED: A randomized controlled trial

by myneuronews January 8, 2026

by myneuronews January 8, 2026

Study Overview This study investigates the effectiveness of intravenous (IV) dexamethasone when used as an …

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Traumatic brain injury
Author’s Reply to: Comment on “Orthostatic Tachycardia in Children With and Without Persisting Postconcussion Symptoms Following Mild Traumatic Brain Injury: A Prospective Controlled Study”

by myneuronews January 8, 2026

by myneuronews January 8, 2026

Study Overview The research focused on comparing the presence and severity of orthostatic tachycardia in …

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Traumatic brain injury
Preexisting Mental Health Disorders Are Associated With Acute Clinical Presentation and Longitudinal Recovery Trajectories in Adolescents With Concussion

by myneuronews January 8, 2026

by myneuronews January 8, 2026

Study Overview The focus of this research was to investigate the relationship between preexisting mental …

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Traumatic brain injury
Brain creatine concentrations are associated with sex and symptom severity after concussion: a cross-sectional MR-spectroscopy investigation of adolescents with concussion

by myneuronews January 8, 2026

by myneuronews January 8, 2026

Study Overview The investigation focused on the relationship between brain creatine concentrations and both sex …

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Headaches
Real-world assessment of current migraine prophylaxis in Egypt: a multicenter national study

by myneuronews January 8, 2026

by myneuronews January 8, 2026

Study Overview The research conducted aimed to evaluate the existing practices regarding migraine prophylaxis across …

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Headaches
Current trends and projections for potential acupuncture needs globally and in China: evidence from the Global Burden of Disease Study 2021

by myneuronews January 6, 2026

by myneuronews January 6, 2026

Global Acupuncture Needs Assessment The assessment of global acupuncture needs involves a multi-faceted approach that …

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Traumatic brain injury
Effectiveness of a Customized Rehabilitation Program for Adults With Post-Concussion Syndrome-A Randomized Controlled Crossover Trial

by myneuronews January 6, 2026

by myneuronews January 6, 2026

Study Overview The research focused on assessing the effectiveness of a tailored rehabilitation program specifically …

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Traumatic brain injury
Synthetic Cannabinoid Use and Sports-Related Concussion Risk Among US Adolescents: Implications for School Health Screening and Prevention

by myneuronews January 6, 2026

by myneuronews January 6, 2026

Risk Factors for Synthetic Cannabinoid Use Synthetic cannabinoids, often marketed as legal alternatives to marijuana, …

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Incretin Mimetics as Potential Therapeutics for Concussion and Traumatic Brain Injury: A Narrative Review
Traumatic brain injury (TBI) represents a significant health concern, with an estimated 70 million annual cases worldwide. Mild brain trauma (concussions) is the most common TBI (81%), followed by moderate (11%) and severe (8%). Cytokine release and neuroinflammation after TBI may cause blood-brain barrier and tissue damage, triggering unfavorable outcomes, including disabilities and mortality. Current […]
N-Stearidonoylethanolamine Restores CA1 Synaptic Integrity and Reduces Astrocytic Reactivity After Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI) disrupts hippocampal network function through coordinated alterations in glial reactivity, synaptic integrity, and adult neurogenesis. Effective therapeutic approaches targeting these interconnected processes remain limited. Lipid-derived molecules capable of modulating these mTBI-induced disturbances are emerging as promising neuroprotective candidates. Here, we investigated the effects of N-stearidonylethanolamine (SDEA), an ω-3 ethanolamide, in […]
Effects of persistent post-concussion symptoms on neurocognitive, motor, and neurophysiological outcomes
CONCLUSION: The PPCS group demonstrated greater symptom reporting and severity, worse neurocognitive performance, worse balance and gait performance, and altered neurophysiology. Further, females with PPCS demonstrated worse balance and gait performance compared to all other groups.
Injury-environment interaction: microglial priming by mTBI creates vulnerability to subsequent stress via the HMGB1-RAGE axis
CONCLUSION: Our study untangles a "priming-triggering" mechanism of injury-environment interaction, identifying the HMGB1-RAGE axis as its key molecular mediator. This finding not only enhances our understanding of how latent vulnerability transitions into overt neuropsychiatric disease, but also provides a promising target for preventive intervention.
Relationship between illness perceptions, coping style and post-concussion symptoms after systemic traumatic injury: A comparison of those with and without mild traumatic brain injury
Research has reported variable findings when investigating the relationship between outcome and coping style and illness perceptions after mild traumatic brain injury (mTBI). The present study investigated 138 individuals who had been admitted to hospital after suffering a traumatic systemic injury, with 91 of these individuals also fulfilling criteria for mTBI and 47 comprising a […]