Tag:

metabolomics

Dementia
Systematic post-translational modification genome wide identifies therapeutic targets for Alzheimer’s disease: evidence from multi-cohort analysis

by myneuronews October 30, 2025

by myneuronews October 30, 2025

Identifying Therapeutic Targets In recent years, identifying therapeutic targets for Alzheimer’s disease (AD) has gained …

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Traumatic brain injury
Brain-derived exosomes from aged mice accelerate cognitive decline in repeated mild traumatic brain injury by activating neuronal Tnfrsf25

by myneuronews October 18, 2025

by myneuronews October 18, 2025

Exosome Characteristics Exosomes are small extracellular vesicles that range from 30 to 150 nanometers in …

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Functional neurological disorders
Serum biomarkers in epilepsy: More than meets the eye

by myneuronews October 10, 2025

by myneuronews October 10, 2025

Serum Biomarkers in Epilepsy Recent research has increasingly focused on serum biomarkers as valuable tools …

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Functional neurological disorders
Serum biomarkers in epilepsy: More than meets the eye

by myneuronews October 10, 2025

by myneuronews October 10, 2025

Serum Biomarkers Overview Serum biomarkers have emerged as a critical aspect of understanding and diagnosing …

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Traumatic brain injury
Exercise-induced molecular modulation following mTBI: A multi-omics study in male mice

by myneuronews October 9, 2025

by myneuronews October 9, 2025

Study Overview This study investigates the effects of exercise on molecular changes following a mild …

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Functional neurological disorders
Investigating the role of a novel hemizygous FAAH2 variant in neurological and metabolic disorders

by myneuronews July 31, 2025

by myneuronews July 31, 2025

Role of FAAH2 in Neurological Disorders FAAH2, or fatty acid amide hydrolase 2, is an …

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Functional neurological disorders
Integrated Transcriptomic Analysis Provided Diagnostic and Pathophysiological Insights for Epilepsy

by myneuronews July 23, 2025

by myneuronews July 23, 2025

Integrated Transcriptomic Insights Recent advancements in transcriptomic analysis have opened new avenues for understanding the …

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Dementia
Embracing the Modern Biochemistry of Brain Metabolism

by myneuronews July 21, 2025

by myneuronews July 21, 2025

Understanding Brain Metabolism The brain is an extraordinarily energy-demanding organ, consuming approximately 20% of the …

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Dementia
Metabolic changes in the one-carbon metabolism-related amino acids during etoposide-induced cellular senescence of neuronal cells

by myneuronews July 3, 2025

by myneuronews July 3, 2025

Metabolic Alterations in Neuronal Cells Metabolic changes in neuronal cells, particularly during cellular senescence, play …

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Functional neurological disorders
Development of a novel liquid chromatography-tandem mass spectrometry based enzymatic assay of 5,10-methylenetetrahydrofolate reductase

by myneuronews July 2, 2025

by myneuronews July 2, 2025

Enzymatic Assay Development The development of a novel enzymatic assay for 5,10-methylenetetrahydrofolate reductase (MTHFR) taps …

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Interventional Treatment Strategies for Headache and Facial Pain
Interventional Techniques and Approaches Interventional techniques for managing headache and facial pain involve various procedures…
Systematic post-translational modification genome wide identifies therapeutic targets for Alzheimer’s disease: evidence from multi-cohort analysis
Identifying Therapeutic Targets In recent years, identifying therapeutic targets for Alzheimer’s disease (AD) has gained…
Functional Connectivity Gradients Reveal Altered Hierarchical Cortical Organization in Functional Neurological Disorder
Functional Connectivity Analysis Functional connectivity analysis has emerged as a pivotal method for understanding how…
An Intervention to Improve Emotion Regulation in Individuals With Traumatic Brain Injury: A Randomized Controlled Trial
Study Overview This research focused on assessing the effectiveness of a targeted intervention aimed at…
Evolution of Axonal Injury in the Closed Head Impact Model of Engineered Rotational Acceleration in Adult Ferrets
Study Overview This research examines the impact of engineered rotational acceleration on axonal injury in…

SaVeBRAIN.Kids-study protocol for a cluster-randomized stepped-wedge trial to reduce hospitalizations for mild traumatic brain injury in children in Germany
BACKGROUND: Traumatic brain injury (TBI) is one of the most important pediatric conditions worldwide. In Germany, hospitalization rates for mild TBI drastically exceed hospitalization rates from similar healthcare systems.
An Intervention to Improve Emotion Regulation in Individuals With Traumatic Brain Injury: A Randomized Controlled Trial
CONCLUSIONS: Evidence supports the efficacy of Online EmReg to improve ER following TBI.
Evolution of Axonal Injury in the Closed Head Impact Model of Engineered Rotational Acceleration in Adult Ferrets
Concussion-related symptoms, such as impaired balance, slower processing speed, attention deficits, memory dysfunction, and irritability, are thought to result from diffuse axonal injury (DAI), characterized by selective damage to white matter axons. Axons subjected to this mechanical stretch injury exhibit diverse pathological changes, including disruption of axonal transport, neurofilament compaction and degradation, myelin sheath disruption, […]
Brain Injury Within Intimate Partner Violence: What Are the Cognitive Effects?
Intimate partner violence (IPV) is a worldwide health concern with devastating implications for physical, mental, and cognitive health. IPV-associated brain injuries (IPV-BIs) induced through impacts to the head (e.g., mild traumatic brain injury [mTBI]) and non-fatal strangulation (NFS; i.e., a hypoxic-ischemic injury) have long been overlooked among IPV victim-survivors. Identifying their presence and consequences is […]
Specific alterations of reactive species interactome markers reflect recovery after mild traumatic brain injury
Recovery from mild traumatic brain injury (mTBI) is believed to be mediated by the secondary injury response with oxidative stress (OS) playing a central role. Previous studies have largely examined isolated OS markers, yielding inconsistent results. This study adopts a more integrated approach by investigating various components of the reactive species interactome (RSI), a conceptual […]