Tag:

neurodegenerative diseases

Dementia
Regional cortical network atrophy predicts progression to dementia in the Lewy body diseases

by myneuronews December 7, 2025

by myneuronews December 7, 2025

Cortical Network Atrophy and Dementia The condition known as dementia can manifest through various neurodegenerative …

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Dementia
Differential microglial responses to structurally distinct alpha-synuclein polymorphs

by myneuronews December 6, 2025

by myneuronews December 6, 2025

Differential Responses of Microglia Microglia, the resident immune cells of the central nervous system, exhibit …

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Traumatic brain injury
Mechanisms of naozhenning in inhibiting neuronal ferroptosis and alleviating brain recurrent mild traumatic brain injury in a rat model

by myneuronews December 4, 2025

by myneuronews December 4, 2025

Mechanisms of Ferroptosis Inhibition Ferroptosis is a distinct form of regulated cell death characterized by …

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Functional neurological disorders
Psychiatric presentation of Gerstmann-Sträussler-Scheinker disease with 9-OPRI mutation in PRNP gene: a case report

by myneuronews December 2, 2025

by myneuronews December 2, 2025

Clinical Presentation The patient presented in this case report exhibited a variety of psychiatric symptoms …

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Functional neurological disorders
Psychiatric presentation of Gerstmann-Sträussler-Scheinker disease with 9-OPRI mutation in PRNP gene: a case report

by myneuronews December 2, 2025

by myneuronews December 2, 2025

Case Overview In this study, we explore the case of a patient diagnosed with Gerstmann-Sträussler-Scheinker …

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Functional neurological disorders
Psychiatric presentation of Gerstmann-Sträussler-Scheinker disease with 9-OPRI mutation in PRNP gene: a case report

by myneuronews December 2, 2025

by myneuronews December 2, 2025

Clinical Features of Gerstmann-Sträussler-Scheinker Disease Gerstmann-Sträussler-Scheinker disease (GSS) is a rare genetic disorder that predominantly …

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Functional neurological disorders
Psychiatric presentation of Gerstmann-Sträussler-Scheinker disease with 9-OPRI mutation in PRNP gene: a case report

by myneuronews December 2, 2025

by myneuronews December 2, 2025

Clinical Presentation and Symptoms Gerstmann-Sträussler-Scheinker disease (GSS) is a rare neurodegenerative disorder classified as a …

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Traumatic brain injury
Concussion recovery: dual task performance and prioritization

by myneuronews December 1, 2025

by myneuronews December 1, 2025

Concussion Mechanisms Concussions result from a variety of forces acting on the brain, primarily due …

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Traumatic brain injury
Worrying about Concussions and Brain Health is Strongly Associated with Psychological Distress in Former Elite Rugby League Players

by myneuronews December 1, 2025

by myneuronews December 1, 2025

Worrying About Concussions Concerns regarding concussions have become increasingly prevalent, particularly among athletes in contact …

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Dementia
Identification of expanded and interrupted ATXN2 repeat expansions in Parkinson’s disease and Lewy Body Dementia cohorts

by myneuronews November 27, 2025

by myneuronews November 27, 2025

Study Overview This research investigates the presence and significance of expanded and interrupted repeat expansions …

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Management of traumatic brain injury in a large-scale combat environment
The United States Armed Forces face the potential reemergence of large-scale combat operations (LSCO) as the predominant operating environment of the 21st century as a result of growing geopolitical conflict between the United States and its near-peer rivals. In a LSCO environment, the Military Health System (MHS) may encounter casualty rates that could quickly overwhelm […]
Sex Differences in Subacute Blood Biomarker Levels and Associations With Post-Concussion Symptom Severity in Adolescents With Concussion
CONCLUSION: This study highlights sex-specific biomarker differences during adolescent concussion recovery and the importance of understanding how sex differences may influence symptom burden and recovery trajectories. Future research should examine hormonal influences on biomarker profiles and prolonged symptomatology.
Long-Term Postdeployment Clinical Subtypes of Risk and Resiliency in Brain Injury and Neurodegeneration
CONCLUSIONS AND RELEVANCE: In this cohort study of service members, clinical outcome clustering revealed key postdeployment subtypes that evolved over time. Cerebellar and brainstem volumes were significantly different by cluster. Regional differences were evident years before when stratified by these 10-year clusters. These findings underscore the need to appreciate not only the heterogeneity of brain […]
Post-traumatic headache phenotypes and clinical characteristics
Background/AimPost-traumatic headache often resembles migraine or tension-type headache, but distinct phenotype and clinical characteristics necessitate further delineation. We aimed to characterize the clinical phenotype, headache patterns, associated features and comorbidities, medication patterns and functional impact of post-traumatic headache in an adult population following mild traumatic brain injury.MethodsThis is a cross-sectional analysis of a cohort of […]
Concussion in the Wild: Clinical Utility of Ambulatory Assessment of Symptoms and Everyday Exposures in Adolescents and Adults with Concussion
CONCLUSIONS: Valid estimates of concussion symptoms may be obtained via remote, unsupervised, high-frequency assessment. In addition to EMA-based symptom scores, avoidance behavior and symptom reactivity may yield prognostic information about risk for protracted recovery.