Tag:

neurodegenerative diseases

Stroke
Exploring astaxanthin: a comprehensive review on its pharmacokinetics properties and neuroprotective potential

by myneuronews May 13, 2025

by myneuronews May 13, 2025

Astaxanthin Pharmacokinetics Astaxanthin, a carotenoid known for its remarkable color and antioxidant properties, is increasingly …

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Dementia
Intranasal Delivery of BACE1 siRNA and Berberine via Engineered Stem Cell Exosomes for the Treatment of Alzheimer’s Disease

by myneuronews May 12, 2025

by myneuronews May 12, 2025

Treatment Strategy Overview In recent years, the exploration of innovative approaches to treat Alzheimer’s disease …

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Functional neurological disorders
Apolipoprotein E (APOE) and Alzheimer’s disease risk in a Ugandan population: A pilot case-control study

by myneuronews May 12, 2025

by myneuronews May 12, 2025

Apolipoprotein E Genotypes and Alzheimer’s Disease The study investigated the relationship between different genotypes of …

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Functional neurological disorders
Handwriting, touchscreen dexterity and bradykinesia measures in Parkinson’s disease: a feature selection study

by myneuronews May 11, 2025

by myneuronews May 11, 2025

Background on Parkinson’s Disease and Motor Symptoms Parkinson’s disease is a progressive neurodegenerative disorder primarily …

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Traumatic brain injury
Cellular and molecular mechanisms of pathological tau phosphorylation in traumatic brain injury: implications for chronic traumatic encephalopathy

by myneuronews May 10, 2025

by myneuronews May 10, 2025

Pathological tau phosphorylation mechanisms Tau is a critical protein in the brain, primarily known for …

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Traumatic brain injury
Cellular and molecular mechanisms of pathological tau phosphorylation in traumatic brain injury: implications for chronic traumatic encephalopathy

by myneuronews May 10, 2025

by myneuronews May 10, 2025

Pathological Tau Phosphorylation Mechanisms Tau protein is a key player in maintaining the structural integrity …

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Movement Disorders
The prodromal individuals’ perspective on active recruitment for early detection of α-synucleinopathies

by myneuronews May 9, 2025

by myneuronews May 9, 2025

Perspective of Prodromal Individuals The perspective of individuals in the prodromal stage of α-synucleinopathies sheds …

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Functional neurological disorders
Electrophysiological characterisation of intranigral-grafted hiPSC-derived dopaminergic neurons in a mouse model of Parkinson’s disease

by myneuronews May 9, 2025

by myneuronews May 9, 2025

Electrophysiological Properties of hiPSC-Derived Neurons The study begins by examining the electrophysiological properties of human-induced …

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Functional neurological disorders
Electrophysiological characterisation of intranigral-grafted hiPSC-derived dopaminergic neurons in a mouse model of Parkinson’s disease

by myneuronews May 9, 2025

by myneuronews May 9, 2025

Background and Rationale The treatment and study of Parkinson’s disease (PD) continue to evolve, particularly …

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Dementia
Temporal transcriptomic changes in the THY-Tau22 mouse model of tauopathy display cell type- and sex-specific differences

by myneuronews May 7, 2025

by myneuronews May 7, 2025

Study Overview The study investigates the temporal changes in gene expression occurring in the brains …

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The role of microglia in multiple sclerosis: implications for treatment with Bruton’s tyrosine kinase inhibitors
Microglia Function in Multiple Sclerosis Microglia, the primary immune cells of the central nervous system…
Impaired physical fitness in pediatric inflammatory bowel disease
Impaired Fitness in Pediatric Patients Pediatric patients with inflammatory bowel disease (IBD), such as Crohn’s…
Research status and future perspectives of IL-27 in the treatment of stroke (Review)
Current Understanding of IL-27 in Stroke Interleukin-27 (IL-27) is a cytokine that belongs to the…
Human Herpesvirus-6 Infectious Meningitis With Lymphadenitis in an Immunocompetent Adult
Study Overview This research explored a case involving Human Herpesvirus-6 (HHV-6) leading to infectious meningitis…
circ_0005654 as a Sponge of the miR-588 Dual Pathway to Promote α-Synuclein Expression
Study Overview The investigation centers around the long non-coding RNA circ_0005654 and its role as…

Post-Concussion Changes in the Functional Brain Connectome Relative to Pre-Injury Baseline: A Prospective Observational Study
There is growing concern about the long-term health consequences of concussion, stemming from its high incidence and evidence of post-injury sequelae. This has raised critical questions about clinical assessments of concussion recovery, and whether brain function has fully recovered at medical clearance. The major knowledge gap is only partly addressed by conventional cross-sectional neuroimaging studies, […]
Identifying and predicting headache trajectories among those with acute post-traumatic headache
CONCLUSION: This study identified subgroups of individuals with acute PTH with distinct headache improvement trajectories. The proposed ML method accurately classified individuals into these subgroups using the minimally necessary early headache data for each person, including detecting the subgroup with the mildest headaches at 2 weeks. This approach could offer an estimated forecast of headache […]
Epidemiology of Traumatic brain injury in Ethiopia: A systematic review and meta-analysis of prevalence, mechanisms, and outcomes
CONCLUSION: The meta-analysis underscores the impact of TBI, in Ethiopia with high mortality rates and associated challenges. The results underscore the pressing requirement for measures to decrease TBIs linked to accidents and violence while also enhancing emergency services access and strengthening neurosurgeons capabilities, in Ethiopian medical facilities.
Assessing the capability of the corneal blink reflex to display neurological changes following subconcussive head impacts
INTRODUCTION: This study examines the capability of detecting neurological changes caused by subconcussive head impacts by analyzing the blink reflex of an individual when they encounter puffs of air as a stimulus.
A Qualitative Study of Collegiate Student-Athlete Experiences of Recovery After Concussion
CONCLUSIONS: Our findings indicate that experiences after concussion are influenced by factors including expectations for recovery, managing symptoms, and navigating decision-making, and by relationships and the social environment. Findings have implications for the way concussion is managed, and the design and application of new treatment and management guidelines for concussion. Future targeted work should investigate […]