Tag:

neuroinflammation

Traumatic brain injury
Development of a modified weight-drop apparatus for closed-skull, repetitive mild traumatic brain injuries in a mouse model

by myneuronews August 6, 2025

by myneuronews August 6, 2025

Study Overview The research focuses on the development of a specialized apparatus designed to replicate …

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Functional neurological disorders
AAV-based gene therapy ameliorates neurological deficits in a mouse model of childhood-onset neurodegeneration with cerebellar atrophy (CONDCA)

by myneuronews August 4, 2025

by myneuronews August 4, 2025

Study Summary The study investigates the efficacy of adeno-associated virus (AAV)-based gene therapy in a …

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Traumatic brain injury
Knockout of indoleamine 2,3-dioxygenase 1 gene expression improves depressive and anxiety-like phenotypes in a murine model of mild traumatic brain injury

by myneuronews August 3, 2025

by myneuronews August 3, 2025

Study Overview The research investigates the effects of knocking out the expression of the indoleamine …

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Dementia
Environmental aluminum exposure and Alzheimer’s disease risk: Evidence from a systematic review and meta-analysis

by myneuronews August 1, 2025

by myneuronews August 1, 2025

Study Overview The investigation into the potential link between environmental aluminum exposure and the risk …

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Functional neurological disorders
Investigating the role of a novel hemizygous FAAH2 variant in neurological and metabolic disorders

by myneuronews July 31, 2025

by myneuronews July 31, 2025

Role of FAAH2 in Neurological Disorders FAAH2, or fatty acid amide hydrolase 2, is an …

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Dementia
Examination of age- and sex-related changes in protein expression within the hippocampus and prefrontal cortex during withdrawal from a subchronic history of binge-drinking in C57BL/6J mice

by myneuronews July 29, 2025

by myneuronews July 29, 2025

Study Overview This study investigates the impact of binge-drinking behavior on protein expression in specific …

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Traumatic brain injury
Neurological Disorders and Clinical Progression in Boxers from the 20th Century: A Narrative Review

by myneuronews July 29, 2025

by myneuronews July 29, 2025

Historical Context of Neurological Disorders The understanding of neurological disorders in Boxers has evolved significantly …

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Dementia
Unveiling blood biomarkers for neuronal hyperplasticity: Insights from AD molecular subtyping, a comprehensive review

by myneuronews July 25, 2025

by myneuronews July 25, 2025

Study Overview The research focuses on the exploration of blood biomarkers that indicate neuronal hyperplasticity, …

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Traumatic brain injury
Microglial depletion and repopulation differentially modulate sleep and inflammation in a mouse model of traumatic brain injury

by myneuronews July 24, 2025

by myneuronews July 24, 2025

Study Overview This research investigates the complex relationship between microglial cells, sleep patterns, and inflammation …

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Functional neurological disorders
Neuroimaging correlates of genetics in patients with Wilson’s disease

by myneuronews July 24, 2025

by myneuronews July 24, 2025

Neuroimaging Findings in Wilson’s Disease Neuroimaging findings in Wilson’s disease reveal significant alterations in brain …

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Hidden Threat: A Delayed Diagnosis of an Intracranial Impacted Car Key Leading to Brain Abscess
Case Description A 32-year-old male presented to the emergency department with persistent headaches and episodes…
Associations of diabetes mellitus with primary open angle glaucoma and Alzheimer’s disease: a large cohort study in UK biobank
Study Overview The research investigated the connections between diabetes mellitus, primary open-angle glaucoma (POAG), and…
A Proof-of-Concept Development on Speech Analysis for Concussion Detection
Study Overview This research project aims to explore the potential of speech analysis as a…
Reframing Functional Neurological Disorders in Modern Medicine
Understanding Functional Neurological Disorders Functional Neurological Disorders (FND) represent a category of neurological conditions where…
Youth Ages 4 to 13 Trends of Sports Concussions With Loss of Consciousness From 2014-2023 National Electronic Injury Surveillance System
Study Overview The study investigates the occurrence of sports-related concussions, specifically those leading to loss…

Construct Validity of the Tower of London Test: Generating a Construct Specification Equation Relating Problem Characteristics to Problem Difficulty in a Sample of Veterans with Mild Traumatic Brain Injury
The Tower of London (TOL) is a set of problem-solving tasks that are commonly used to measure cognition. No studies have developed construct specification equations (CSEs) to mathematically quantify how the characteristics of test problems relate to the difficulty of the problem in the TOL. We aimed to investigate the relationship between TOL problem characteristics […]
Vibrational spectroscopy methods reveal biochemical changes associated with the glial scar formation after traumatic brain injury
Traumatic brain injury (TBI) is a serious clinical and social problem. Millions of TBI cases, that require hospitalization and consequently burden social security systems, are reported each year. Analysis of the time course of changes that occur in the brain after primary injury may help indicate therapeutic goals and treatment directions that will minimize severe […]
Functional hearing difficulties in Veterans with blast and blunt head trauma are associated with reduced fractional anisotropy in putative auditory radiations
OBJECTIVES: Veterans of recent military conflicts have experienced a high rate of mild traumatic brain injury (mTBI) due to blast exposure. A debilitating symptom often reported by such patients is an impaired ability to perceive complex sounds (e.g., impaired speech comprehension in noisy environments). In a prior report, we found a continuous measure of historical […]
Clinical outcomes and quality of life after endovascular embolization for vein of Galen aneurysmal malformation (VGAM): a study from a low-and middle-income country
CONCLUSION: The long-term neurological outcomes of VGAM embolization remain variable. While staged embolization was significantly associated with outcomes, other factors may contribute. Larger studies are needed to determine the optimal approach for embolization to improve outcomes.
A Proof-of-Concept Development on Speech Analysis for Concussion Detection
Speech signal analysis to support objective clinical decision-making has gained immense interest, especially in neurological disorders. This research assessed the feasibility of speech analysis on the detection of concussions. Using a speech dataset from 82 concussed and 82 healthy participants, we extracted two speech feature sets focusing on Mel Frequency Cepstral Coefficients (MFCCs) to characterize […]