ISG15/ISGylation in central nervous system diseases: molecular mechanisms and therapeutic targeting
Molecular Mechanisms of ISG15/ISGylation ISG15, or interferon-stimulated gene 15, is a small ubiquitin-like modifier that plays a crucial role in […]
Mechanistic insights from experimental autoimmune encephalomyelitis into immune regulation, autophagy, gut microbiota, blood-brain barrier integrity, and NLRP3 inflammasome-mediated pyroptosis in multiple sclerosis: potential clinical implications
Mechanistic Insights into Multiple Sclerosis Multiple sclerosis (MS) is characterized by an autoimmune response that targets the central nervous system,
Immunoregulatory Effect of Curcumin on Experimental Autoimmune Encephalomyelitis (EAE), an Animal Model of Multiple Sclerosis (MS)
Overview of Curcumin’s Effects Curcumin, the active compound derived from the turmeric plant, has garnered significant attention in the scientific
Nitric oxide and traumatic brain injury
Nitric Oxide Mechanisms in Brain Injury Nitric oxide (NO) plays a crucial role in the pathophysiology of traumatic brain injury
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Do apelin and ghrelin play a role in multiple sclerosis? The analysis of patients treated with immunomodulatory therapies
Study overview The research focused on examining the roles of apelin and ghrelin, two peptides with potential implications in metabolic
GV1001: repurposing a telomerase-derived peptide for neurological therapeutics
Peptide Mechanism of Action The peptide derived from telomerase exhibits a unique mechanism that appears to interact with various biological
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Neuronal p38a knockout protects against neurological consequences following repetitive mild traumatic brain injury
Study Overview This research investigates the protective role of a specific genetic alteration, the knockout of the p38a gene, against
Minor neuropsychological deficits and stage 2 of Alzheimer’s disease
Neuropsychological Deficits in Alzheimer’s Alzheimer’s disease, particularly in its second stage, is associated with a range of neuropsychological deficits that
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A glial oxidative signature predicts disability in primary progressive multiple sclerosis and is associated with long-term cognitive decline
Oxidative Signature in Multiple Sclerosis In the context of primary progressive multiple sclerosis (PPMS), the concept of an oxidative signature
Opioid Signaling in Multiple Sclerosis: Emerging Targets for Repair
Opioid Mechanisms in Multiple Sclerosis Opioids, known primarily for their pain-relieving properties, interact with specific receptors in the nervous system.
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