Tag:

neuroinflammation

Dementia
Consideration of sex as a biological variable over the history of the 5xFAD Alzheimer’s Disease mouse model

by myneuronews December 17, 2025

by myneuronews December 17, 2025

Biological Considerations When investigating Alzheimer’s disease through animal models, particularly the 5xFAD mouse model, it …

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Traumatic brain injury
Ultra-high contrast MRI: a new technique for recognizing secondary changes to the brain in patients with persistent symptoms following traumatic brain injury

by myneuronews December 16, 2025

by myneuronews December 16, 2025

Ultra-high Contrast MRI Technique The development of ultra-high contrast magnetic resonance imaging (MRI) represents a …

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Headaches
The P2Y13 receptor-mediated microglial morphological transformation through the p38MAPK signaling pathway contributes to central sensitization in a murine model of chronic migraine

by myneuronews December 15, 2025

by myneuronews December 15, 2025

Study Overview The primary objective of this research was to investigate the role of the …

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Traumatic brain injury
Ferroptosis-Mediated Hippocampal Neuronal Loss Post-mTBI: Chromatin Accessibility Profiling and Single-Nucleus Transcriptomics

by myneuronews December 15, 2025

by myneuronews December 15, 2025

Research Context The brain is a complex organ with numerous cellular interactions, and understanding these …

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Traumatic brain injury
Efficacy and safety of exosomes from Wharton’s Jelly-derived mesenchymal stem cells in traumatic brain injury

by myneuronews December 11, 2025

by myneuronews December 11, 2025

Efficacy of exosomes Exosomes derived from Wharton’s Jelly mesenchymal stem cells (WJ-MSCs) have shown significant …

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Traumatic brain injury
Efficacy and safety of exosomes from Wharton’s Jelly-derived mesenchymal stem cells in traumatic brain injury

by myneuronews December 11, 2025

by myneuronews December 11, 2025

Study Overview This investigation focuses on the therapeutic potential of exosomes derived from Wharton’s Jelly …

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Dementia
Increased Blood Levels of NfL, GFAP, and Placental Growth Factor After Radiotherapy to the Brain

by myneuronews December 9, 2025

by myneuronews December 9, 2025

Study Overview The study investigated the changes in specific biomarkers in the blood of patients …

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Traumatic brain injury
The Application of Lifestyle Medicine in Traumatic Brain Injury

by myneuronews December 8, 2025

by myneuronews December 8, 2025

Overview of Lifestyle Medicine Applications Lifestyle medicine encompasses a range of interventions aimed at improving …

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Dementia
Differential microglial responses to structurally distinct alpha-synuclein polymorphs

by myneuronews December 6, 2025

by myneuronews December 6, 2025

Differential Responses of Microglia Microglia, the resident immune cells of the central nervous system, exhibit …

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Traumatic brain injury
Traumatic brain injury outcomes and mortality predictors in Eastern India: An observational study

by myneuronews December 5, 2025

by myneuronews December 5, 2025

Traumatic brain injury demographics The demographics of individuals experiencing traumatic brain injuries (TBIs) in Eastern …

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Macrophages and iNOS contribute to the effects of dural prolactin and repeated stress in mouse migraine models
Study Overview The investigation into the interplay between macrophages, inducible nitric oxide synthase (iNOS), and…
The biomarker and clinical changes across the Alzheimer’s continuum study (BCAS): rationale, design, and baseline characteristics of the first 1,013 participants
Study Overview The BCAS study focuses on understanding the progression of Alzheimer’s disease through a…
Women’s Issues and Female-specific Factors in Functional Neurological Disorder
Women’s Unique Experiences in FND Women facing Functional Neurological Disorder (FND) often encounter a unique…
Sex differences in the clinical characteristics of South African patients with functional seizures in a public and a private hospital
Sex Differences in Functional Seizures Research has increasingly highlighted the importance of sex differences in…
Developing Topics
Topic Identification In the early stages of research, selecting a compelling and relevant topic is…

Utility of the Brain Gauge in Traumatic Brain Injury: Results of the Al Asad Missile Exposure Traumatic Brain Injury and Health Implications Study
CONCLUSION: Brain Gauge performance is significantly impaired upon initial administration weeks after blast TBI in SMs but shows improvement upon readministration 4-5 days later. Findings in this small sample require replication in larger populations.
The feasibility and efficacy of a virtual, symptom-guided aerobic exercise intervention to improve cognition in mild traumatic brain injury: A single-blind pilot randomized control trial with an active comparator group
CONCLUSION: These findings establish that virtual, supervised, symptom-guided exercise interventions are feasible and safe for mTBI populations, with preliminary evidence suggesting aerobic exercise specifically benefits cognitive flexibility and sleep quality following mTBI. A fully powered randomized controlled trial is warranted to confirm these effects.
Clinical Manifestations
The prognosis of progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) involves a survival shorter than 10-years since symptom onset with development of marked disability. Patients will often progress to require increased assisstance with daily living activities, and symptomatic therapies with partial effectiveness that lead to experiencing decreased quality of life. Speech difficulties and swallowing […]
Retraining dorsal visual pathways improves cognitive skills and executive control networks following mild traumatic brain injury
CONCLUSION: Dorsal visual pathway retraining followed by targeted working memory exercises demonstrates superior therapeutic efficacy for cognitive rehabilitation following mTBI compared to conventional approaches. The intervention promotes beneficial neuroplasticity extending to memory-related brain regions, supporting its potential as a targeted, mechanistically-informed therapy for post-concussive cognitive deficits.
Office-based Neurophysiological Assessments for Diagnosis and Prognosis of Concussion
Patients with concussion often receive insufficient and/or ineffective diagnostic workups. A limiting factor for prompt and accurate diagnosis is the scarcity of practical and effective concussion diagnostics that can be used by private-practice physicians. This gap in the diagnostic process can delay the implementation of crucial interventions. The absence of an affirmative concussion diagnosis leaves […]