Tag:

personalized treatment

Dementia
Cognitive performance in patients with ischemic stroke and additional myocardial injury – results from the multicenter prospective observational PRAISE study

by myneuronews November 4, 2025

by myneuronews November 4, 2025

Cognitive outcomes in stroke patients Cognitive performance is a critical aspect of recovery after a …

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Dementia
Long-term dementia risk following electroconvulsive therapy: A GRADE-assessed systematic review and meta-analysis

by myneuronews November 1, 2025

by myneuronews November 1, 2025

Study Overview Electroconvulsive therapy (ECT) has been a significant intervention in the treatment of severe …

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Traumatic brain injury
Association Between Intraindividual Variability in Cognitive Performance and White Matter Organisation in Chronic Mild Traumatic Brain Injury

by myneuronews November 1, 2025

by myneuronews November 1, 2025

Study Overview This research delves into the relationship between cognitive performance variability and white matter …

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Functional neurological disorders
Longitudinal gait changes in functional neurological disorder: A 12-month prospective study

by myneuronews October 31, 2025

by myneuronews October 31, 2025

Longitudinal Gait Analysis Longitudinal gait analysis in the context of functional neurological disorders (FND) has …

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Traumatic brain injury
Brain Injury Within Intimate Partner Violence: What Are the Cognitive Effects?

by myneuronews October 30, 2025

by myneuronews October 30, 2025

Cognitive Impacts of Brain Injury Brain injuries incurred during episodes of intimate partner violence can …

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Traumatic brain injury
Specific alterations of reactive species interactome markers reflect recovery after mild traumatic brain injury

by myneuronews October 30, 2025

by myneuronews October 30, 2025

Study Overview This research delves into the complex interactions of reactive species and their markers …

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Traumatic brain injury
Brain Injury Within Intimate Partner Violence: What Are the Cognitive Effects?

by myneuronews October 30, 2025

by myneuronews October 30, 2025

Cognitive Effects of Brain Injury Brain injuries sustained during incidents of intimate partner violence can …

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Functional neurological disorders
Functional Connectivity Gradients Reveal Altered Hierarchical Cortical Organization in Functional Neurological Disorder

by myneuronews October 30, 2025

by myneuronews October 30, 2025

Functional Connectivity Analysis In recent years, functional connectivity analysis has emerged as a pivotal tool …

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Traumatic brain injury
Evolution of Axonal Injury in the Closed Head Impact Model of Engineered Rotational Acceleration in Adult Ferrets

by myneuronews October 30, 2025

by myneuronews October 30, 2025

Study Overview This research investigates the progression of axonal injury resulting from a model of …

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Traumatic brain injury
The clinical significance of serum LY86-AS1 in the early detection and prognostic evaluation of traumatic brain injury

by myneuronews October 28, 2025

by myneuronews October 28, 2025

Serum LY86-AS1 and Traumatic Brain Injury Recent research indicates that LY86-AS1, a long non-coding RNA, …

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Incretin Mimetics as Potential Therapeutics for Concussion and Traumatic Brain Injury: A Narrative Review
Traumatic brain injury (TBI) represents a significant health concern, with an estimated 70 million annual cases worldwide. Mild brain trauma (concussions) is the most common TBI (81%), followed by moderate (11%) and severe (8%). Cytokine release and neuroinflammation after TBI may cause blood-brain barrier and tissue damage, triggering unfavorable outcomes, including disabilities and mortality. Current […]
N-Stearidonoylethanolamine Restores CA1 Synaptic Integrity and Reduces Astrocytic Reactivity After Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI) disrupts hippocampal network function through coordinated alterations in glial reactivity, synaptic integrity, and adult neurogenesis. Effective therapeutic approaches targeting these interconnected processes remain limited. Lipid-derived molecules capable of modulating these mTBI-induced disturbances are emerging as promising neuroprotective candidates. Here, we investigated the effects of N-stearidonylethanolamine (SDEA), an ω-3 ethanolamide, in […]
Effects of persistent post-concussion symptoms on neurocognitive, motor, and neurophysiological outcomes
CONCLUSION: The PPCS group demonstrated greater symptom reporting and severity, worse neurocognitive performance, worse balance and gait performance, and altered neurophysiology. Further, females with PPCS demonstrated worse balance and gait performance compared to all other groups.
Injury-environment interaction: microglial priming by mTBI creates vulnerability to subsequent stress via the HMGB1-RAGE axis
CONCLUSION: Our study untangles a "priming-triggering" mechanism of injury-environment interaction, identifying the HMGB1-RAGE axis as its key molecular mediator. This finding not only enhances our understanding of how latent vulnerability transitions into overt neuropsychiatric disease, but also provides a promising target for preventive intervention.
Relationship between illness perceptions, coping style and post-concussion symptoms after systemic traumatic injury: A comparison of those with and without mild traumatic brain injury
Research has reported variable findings when investigating the relationship between outcome and coping style and illness perceptions after mild traumatic brain injury (mTBI). The present study investigated 138 individuals who had been admitted to hospital after suffering a traumatic systemic injury, with 91 of these individuals also fulfilling criteria for mTBI and 47 comprising a […]