Tag:

transcriptomics

Functional neurological disorders
Investigating the role of a novel hemizygous FAAH2 variant in neurological and metabolic disorders

by myneuronews July 31, 2025

by myneuronews July 31, 2025

Role of FAAH2 in Neurological Disorders FAAH2, or fatty acid amide hydrolase 2, is an …

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Functional neurological disorders
Integrated Single-Cell and Spatial Transcriptomic Analysis Identifies ISR-Related Genes Driving Immune Regulation in Parkinson’s Disease

by myneuronews July 21, 2025

by myneuronews July 21, 2025

Integrated Transcriptomic Approaches The integration of transcriptomic approaches offers a powerful way to glean insights …

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Dementia
Metabolic changes in the one-carbon metabolism-related amino acids during etoposide-induced cellular senescence of neuronal cells

by myneuronews July 3, 2025

by myneuronews July 3, 2025

Metabolic Alterations in Neuronal Cells Metabolic changes in neuronal cells, particularly during cellular senescence, play …

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Headaches
Changes in metabolite profiles in the cerebrospinal fluid and in human neuronal cells upon tick-borne encephalitis virus infection

by myneuronews June 14, 2025

by myneuronews June 14, 2025

Metabolite Profile Changes Upon infection with the tick-borne encephalitis virus (TBEV), significant alterations occur in …

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Traumatic brain injury
Single-nucleus and spatial signatures of the brainstem in normal brain and mild traumatic brain injury in male mice

by myneuronews May 31, 2025

by myneuronews May 31, 2025

Study Overview This investigation delves into the complexities of brainstem alterations in male mice, specifically …

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Traumatic brain injury
Single-nucleus and spatial signatures of the brainstem in normal brain and mild traumatic brain injury in male mice

by myneuronews May 31, 2025

by myneuronews May 31, 2025

Study Overview The research investigates the brainstem’s cellular and molecular properties in male mice, specifically …

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Functional neurological disorders
Developing a disease-specific accessible transcriptional signature as a biomarker for ataxia with oculomotor apraxia type 2

by myneuronews May 24, 2025

by myneuronews May 24, 2025

Background of Ataxia with Oculomotor Apraxia Type 2 Ataxia with oculomotor apraxia type 2 (AOA2) …

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Traumatic brain injury
Single-Cell RNA and Transcriptome Sequencing to Analyze the Role of Lactate Metabolism in Traumatic Brain Injury Astrocytes

by myneuronews May 21, 2025

by myneuronews May 21, 2025

Role of Lactate Metabolism in Astrocytes Lactate metabolism plays a pivotal role in cellular energy …

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Functional neurological disorders
Scar-associated macrophages and biliary epithelial cells interaction exacerbates hepatic fibrosis in biliary atresia

by myneuronews May 18, 2025

by myneuronews May 18, 2025

Mechanisms of Macrophage and Biliary Epithelial Cell Interaction The interaction between macrophages and biliary epithelial …

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Functional neurological disorders
Spatial Multiomics Toward Understanding Neurological Systems

by myneuronews May 13, 2025

by myneuronews May 13, 2025

Understanding Spatial Multiomics Spatial multiomics is revolutionizing our understanding of the brain and its complex …

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Exploring the Effects of Psilocybin on Depression and the Mediating Role of the 5-HT2A Receptor: A Systematic Review
Study Overview This systematic review aims to investigate the relationship between psilocybin, a naturally occurring…
Chronic Pain in Parkinson’s Disease: Prevalence, Sex Differences, Regional Anatomy and Comorbidities
Chronic Pain Overview Chronic pain is a complex and multifaceted condition that persists over an…
Longitudinal Effects of Mild Traumatic Brain Injury on the Gut Microbiome and Acoustic Startle Response in Male and Female Rats
Study Overview This research investigates the consequences of mild traumatic brain injury (mTBI) on both…
The Qualitative Experiences of Youth With Disorders of Visual Efficiency
Understanding Visual Efficiency Disorders Visual efficiency disorders encompass a range of conditions that affect the…
Somatic Symptom and Related Disorders and Mild Traumatic Brain Injury: A Systematic Review
Overview of Somatic Symptom Disorders Somatic symptom disorders encompass a range of conditions where individuals…

Quantitative video analysis of head acceleration events: a review
The biomechanics of head acceleration events (HAEs) in sport have received increasing attention due to growing concern over concussion and long-term neurodegenerative disease risk. While wearable sensors, such as instrumented mouthguards (iMGs), are now commonly used to measure HAEs, these devices face well-documented challenges, including poor skull coupling, limited compliance, and high false-positive rates. Video […]
Post-concussion clinical findings of oculomotor function in paediatric patients with persisting symptoms compared to healthy controls
CONCLUSION: The oculomotor profile of persistently symptomatic concussed paediatric participants shows a high frequency of vergence and accommodative deficits, for which NPC and AA are effective screening tools. Further investigation should examine oculomotor deficits in acutely concussed paediatric patients.
Neurodegenerative Diseases in Male Former First-Class New Zealand Rugby Players
CONCLUSIONS: High-level rugby participation amongst males in New Zealand is associated with a small to moderate increase in neurodegenerative disease rates compared to the general population.
Clinical and Financial Impacts of Caring for Mild TBI Patients in the Rural Upper Midwest
BackgroundHealthcare disparities often cause rural BIG 1 TBI patients to be transferred to a higher level of care due to a fear of clinical decline.MethodsWe conducted a retrospective cohort study from 2020 to 2022 that compared patients with the principal diagnosis of BIG1 TBI who were transferred from rural critical access facilities in the upper […]
False-Positive Rates and Associated Factors on the Vestibular/Ocular Motor Screening (VOMS) Using the Military Acute Concussion Evaluation 2 (MACE 2) Cutoffs in U.S. Military Personnel
CONCLUSION: The MACE 2 cutoff resulted in a higher overall rate of at least one false positive across items (35.1%) in this sample of healthy USASOC personnel compared to prior total score cutoffs. Consistent with previous research, a history of motion sickness or concussion was associated with an increased likelihood of false positives. Multivariate predictors […]