Tag:

transcriptomics

Functional neurological disorders
Integrated Single-Cell and Spatial Transcriptomic Analysis Identifies ISR-Related Genes Driving Immune Regulation in Parkinson’s Disease

by myneuronews July 21, 2025

by myneuronews July 21, 2025

Integrated Transcriptomic Approaches The integration of transcriptomic approaches offers a powerful way to glean insights …

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Dementia
Metabolic changes in the one-carbon metabolism-related amino acids during etoposide-induced cellular senescence of neuronal cells

by myneuronews July 3, 2025

by myneuronews July 3, 2025

Metabolic Alterations in Neuronal Cells Metabolic changes in neuronal cells, particularly during cellular senescence, play …

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Headaches
Changes in metabolite profiles in the cerebrospinal fluid and in human neuronal cells upon tick-borne encephalitis virus infection

by myneuronews June 14, 2025

by myneuronews June 14, 2025

Metabolite Profile Changes Upon infection with the tick-borne encephalitis virus (TBEV), significant alterations occur in …

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Traumatic brain injury
Single-nucleus and spatial signatures of the brainstem in normal brain and mild traumatic brain injury in male mice

by myneuronews May 31, 2025

by myneuronews May 31, 2025

Study Overview This investigation delves into the complexities of brainstem alterations in male mice, specifically …

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Traumatic brain injury
Single-nucleus and spatial signatures of the brainstem in normal brain and mild traumatic brain injury in male mice

by myneuronews May 31, 2025

by myneuronews May 31, 2025

Study Overview The research investigates the brainstem’s cellular and molecular properties in male mice, specifically …

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Functional neurological disorders
Developing a disease-specific accessible transcriptional signature as a biomarker for ataxia with oculomotor apraxia type 2

by myneuronews May 24, 2025

by myneuronews May 24, 2025

Background of Ataxia with Oculomotor Apraxia Type 2 Ataxia with oculomotor apraxia type 2 (AOA2) …

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Traumatic brain injury
Single-Cell RNA and Transcriptome Sequencing to Analyze the Role of Lactate Metabolism in Traumatic Brain Injury Astrocytes

by myneuronews May 21, 2025

by myneuronews May 21, 2025

Role of Lactate Metabolism in Astrocytes Lactate metabolism plays a pivotal role in cellular energy …

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Functional neurological disorders
Scar-associated macrophages and biliary epithelial cells interaction exacerbates hepatic fibrosis in biliary atresia

by myneuronews May 18, 2025

by myneuronews May 18, 2025

Mechanisms of Macrophage and Biliary Epithelial Cell Interaction The interaction between macrophages and biliary epithelial …

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Functional neurological disorders
Spatial Multiomics Toward Understanding Neurological Systems

by myneuronews May 13, 2025

by myneuronews May 13, 2025

Understanding Spatial Multiomics Spatial multiomics is revolutionizing our understanding of the brain and its complex …

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Headaches
Diagnosing migraine from genome-wide genotype data: a machine learning analysis

by myneuronews May 6, 2025

by myneuronews May 6, 2025

Background on Migraine and Genomics Migraine is a prevalent and often debilitating neurological condition characterized …

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Early nanoparticle intervention preserves motor function following cervical spinal cord injury
Study Overview The research investigates the effects of early intervention using nanoparticles in the context…
Circulating Immune Cell Signature Analysis in HFpEF Across Species
Study Overview The investigation into circulating immune cell signatures in heart failure with preserved ejection…
Laparoscopic Adrenal Surgery in an Adolescent Boy in the Caribbean With Malignant Hypertension Secondary to Pheochromocytoma: A Case Report and Literature Review
Case Background The subject of this case study is a young male adolescent, presenting with…
Distinct inflammatory profiles in young-onset versus late-onset Alzheimer’s disease
Inflammatory Profiles in Alzheimer’s Disease Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-beta…
Unveiling blood biomarkers for neuronal hyperplasticity: Insights from AD molecular subtyping, a comprehensive review
Study Overview The research focuses on the exploration of blood biomarkers that indicate neuronal hyperplasticity,…

Vestibular dysfunction after mild traumatic brain injury: A systematic review
Objective: Vestibular system dysfunction (VD), a condition characterized by impairments in balance, spatial orientation, and eye movement control, is frequently encountered after mild traumatic brain injury (mTBI). We reviewed the existing literature on the various forms of post-traumatic VD and discuss the epidemiology and natural history, diagnostic methods, assessment tools, and therapeutic interventions crucial to […]
Tools for Diagnosing and Managing Sport-Related Concussion in UK Primary Care: A Scoping Review
CONCLUSIONS: SCAT6, SCOAT6, BIST, and BCPE could enhance SRC care, but their feasibility in UK primary care requires adaptation (e.g., integration with GP IT systems and alignment with NICE guidelines). Further research is required to validate these tools and assess additional training needs.
Elite Ice Hockey Players' Well-Being: A Scoping Review
As mental health has gained prominence in recent years, elite ice hockey players have shared their experience of psychological problems, including adverse alcohol use, anxiety, depression, distress, eating disorders, and sleep disturbances. Mental health remains a sensitive issue for ice hockey players, as stigma, a strong hockey culture, lack of mental health literacy, and negative […]
A systematic review of cheerleading injuries: epidemiological characteristics, biomechanical mechanisms, and prevention strategies
CONCLUSION: Cheerleading injury prevention requires a multidimensional strategy: Implement biomechanical interventions (closed-chain eccentric training and movement technique optimization) to enhance muscle endurance and action control precision; Promote rule optimization and coach certification, establishing standardized difficulty criteria for each level and a risk factor-based assessment and prevention system; Develop pediatric protection standards and professional training systems, […]
Microglial depletion and repopulation differentially modulate sleep and inflammation in a mouse model of traumatic brain injury
Traumatic brain injury (TBI) causes persistent sleep disturbances, leading to long-term neurological consequences and reduced quality of life. We hypothesized that microglial depletion via PLX5622 (PLX), a colony-stimulating factor 1 receptor (CSFR1R) inhibitor, would exacerbate sleep disturbances and alter inflammatory profiles after TBI, and that microglial repopulation would ameliorate these effects. Male mice received PLX […]