Tag:

transcriptomics

Traumatic brain injury
Metabolomics of cerebrospinal fluid following traumatic brain injury: Exploration of biomarkers for secondary injuries and severity

by myneuronews November 14, 2025

by myneuronews November 14, 2025

Metabolomic Profiling Metabolomic profiling involves the comprehensive analysis of metabolites—small molecules that are the end …

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Functional neurological disorders
Investigating the role of a novel hemizygous FAAH2 variant in neurological and metabolic disorders

by myneuronews July 31, 2025

by myneuronews July 31, 2025

Role of FAAH2 in Neurological Disorders FAAH2, or fatty acid amide hydrolase 2, is an …

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Functional neurological disorders
Integrated Single-Cell and Spatial Transcriptomic Analysis Identifies ISR-Related Genes Driving Immune Regulation in Parkinson’s Disease

by myneuronews July 21, 2025

by myneuronews July 21, 2025

Integrated Transcriptomic Approaches The integration of transcriptomic approaches offers a powerful way to glean insights …

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Dementia
Metabolic changes in the one-carbon metabolism-related amino acids during etoposide-induced cellular senescence of neuronal cells

by myneuronews July 3, 2025

by myneuronews July 3, 2025

Metabolic Alterations in Neuronal Cells Metabolic changes in neuronal cells, particularly during cellular senescence, play …

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Headaches
Changes in metabolite profiles in the cerebrospinal fluid and in human neuronal cells upon tick-borne encephalitis virus infection

by myneuronews June 14, 2025

by myneuronews June 14, 2025

Metabolite Profile Changes Upon infection with the tick-borne encephalitis virus (TBEV), significant alterations occur in …

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Traumatic brain injury
Single-nucleus and spatial signatures of the brainstem in normal brain and mild traumatic brain injury in male mice

by myneuronews May 31, 2025

by myneuronews May 31, 2025

Study Overview This investigation delves into the complexities of brainstem alterations in male mice, specifically …

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Traumatic brain injury
Single-nucleus and spatial signatures of the brainstem in normal brain and mild traumatic brain injury in male mice

by myneuronews May 31, 2025

by myneuronews May 31, 2025

Study Overview The research investigates the brainstem’s cellular and molecular properties in male mice, specifically …

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Functional neurological disorders
Developing a disease-specific accessible transcriptional signature as a biomarker for ataxia with oculomotor apraxia type 2

by myneuronews May 24, 2025

by myneuronews May 24, 2025

Background of Ataxia with Oculomotor Apraxia Type 2 Ataxia with oculomotor apraxia type 2 (AOA2) …

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Traumatic brain injury
Single-Cell RNA and Transcriptome Sequencing to Analyze the Role of Lactate Metabolism in Traumatic Brain Injury Astrocytes

by myneuronews May 21, 2025

by myneuronews May 21, 2025

Role of Lactate Metabolism in Astrocytes Lactate metabolism plays a pivotal role in cellular energy …

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Functional neurological disorders
Scar-associated macrophages and biliary epithelial cells interaction exacerbates hepatic fibrosis in biliary atresia

by myneuronews May 18, 2025

by myneuronews May 18, 2025

Mechanisms of Macrophage and Biliary Epithelial Cell Interaction The interaction between macrophages and biliary epithelial …

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Carotid and Vertebral Artery Dissections
Epidemiology and Risk Factors Carotid and vertebral artery dissections are relatively uncommon vascular injuries characterized…
The CSF Levels of Mitochondrial Phosphoenolpyruvate Carboxykinase 2 as a Novel Biomarker in Alzheimer’s Disease
Study Overview The research focuses on the role of mitochondrial phosphoenolpyruvate carboxykinase 2 (PEPCK-M) levels…
Complex dissociation following maternal suicide attempt in a 17-year-old female: a case report
Case Presentation In this case, we explore a 17-year-old female who was brought to the…
Motor stereotypies, Dhat syndrome, and gaming disorder: A masquerading presentation of Wilson’s disease
Wilson’s Disease Overview Wilson’s disease is a rare genetic disorder that results in excessive copper…
Clinical Outcomes in the Patient With Traumatic Brain Injury and Comorbid Obesity: A Scoping Review
Clinical Outcomes in Traumatic Brain Injury Traumatic brain injury (TBI) represents a significant challenge in…

Trauma Exposure Across the Lifespan Is Associated With Persistent Mild TBI Symptoms in US Military Veterans
CONCLUSION: These findings support the inclusion of comprehensive lifetime trauma assessment in chronic mTBI rehabilitation conceptualizations and underscore the potentially prominent role that psychological stressors play in the persistence of mTBI sequelae.
Psychological Health of Female Service Members and Veterans Associated With Mild Traumatic Brain Injury History: A LIMBIC-CENC Study
CONCLUSIONS: FSMVs with ≥1 mTBI history reported greater psychological symptoms than those without. Among FSMVs with lifetime mTBI history, combat-mTBI history was associated with worse PTSD, life satisfaction, and anxiety symptoms. Our findings indicate that a single mTBI, notably combat-related, may adversely impact psychological health, but future research is necessary for longitudinal, comprehensive FSMV health […]
A preliminary study on the prevalence of mental health symptoms in current and former elite kickboxers and their possible association with severe musculoskeletal injuries and concussions
CONCLUSIONS: The substantial prevalence rates of mental health symptoms among current and former elite kickboxers emphasize the need for increased attention in this area. No associations were found between the potential contributing factors and mental health symptoms among current and former elite kickboxers. While further research is needed, raising awareness as well as developing preventive […]
Test-Retest Reliability of the Blast Exposure Threshold Survey in United States Service Members and Veterans
The Blast Exposure Threshold Survey (BETS) is a recently developed measure of lifetime blast exposure. Although promising, it is considered a fundamental tenet to establish that the BETS (and other measures like it) have good psychometric properties before it can be recommended for clinical use. The purpose of this study was to examine the test-retest […]
Traumatic Brain Injury and Depressive Symptoms in Community-Dwelling Older Adults: A Prospective Cohort Study
BACKGROUND AND OBJECTIVES: Mood symptoms are recognized short-term sequelae of traumatic brain injury (TBI). Research regarding depressive symptoms among older, community-based individuals with TBI is limited. Previous studies have largely focused on short-term and intermediate-term follow-up.