Tag:

transcriptomics

Traumatic brain injury
CCL5/RANTES signaling in inflammation dysregulation after mild traumatic brain injury

by myneuronews January 8, 2026

by myneuronews January 8, 2026

CCL5/RANTES Role in Brain Injury CCL5, also known as RANTES (Regulated upon Activation, Normal T …

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Traumatic brain injury
Biomarkers

by myneuronews December 26, 2025

by myneuronews December 26, 2025

Biomarker Definition and Types Biomarkers are biological indicators that provide measurable evidence of specific physiological …

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Dementia
Biomarkers

by myneuronews December 25, 2025

by myneuronews December 25, 2025

Biomarker Definition and Types Biomarkers are biological indicators that are used to measure and evaluate …

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Dementia
Consideration of sex as a biological variable over the history of the 5xFAD Alzheimer’s Disease mouse model

by myneuronews December 17, 2025

by myneuronews December 17, 2025

Biological Considerations When investigating Alzheimer’s disease through animal models, particularly the 5xFAD mouse model, it …

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Traumatic brain injury
Ferroptosis-Mediated Hippocampal Neuronal Loss Post-mTBI: Chromatin Accessibility Profiling and Single-Nucleus Transcriptomics

by myneuronews December 15, 2025

by myneuronews December 15, 2025

Study Overview This research explores the phenomenon of ferroptosis, a form of regulated cell death …

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Traumatic brain injury
Ferroptosis-Mediated Hippocampal Neuronal Loss Post-mTBI: Chromatin Accessibility Profiling and Single-Nucleus Transcriptomics

by myneuronews December 15, 2025

by myneuronews December 15, 2025

Research Context The brain is a complex organ with numerous cellular interactions, and understanding these …

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Traumatic brain injury
Mechanisms of naozhenning in inhibiting neuronal ferroptosis and alleviating brain recurrent mild traumatic brain injury in a rat model

by myneuronews December 4, 2025

by myneuronews December 4, 2025

Mechanisms of Ferroptosis Inhibition Ferroptosis is a distinct form of regulated cell death characterized by …

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Dementia
Single-nucleus and spatial transcriptomic profiling of human temporal cortex and white matter reveals key associations with AD pathology

by myneuronews November 24, 2025

by myneuronews November 24, 2025

Study Overview This study centers on the intricate relationships between cellular profiles in the human …

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Traumatic brain injury
Metabolomics of cerebrospinal fluid following traumatic brain injury: Exploration of biomarkers for secondary injuries and severity

by myneuronews November 14, 2025

by myneuronews November 14, 2025

Metabolomic Profiling Metabolomic profiling involves the comprehensive analysis of metabolites—small molecules that are the end …

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Dementia
Metabolic changes in the one-carbon metabolism-related amino acids during etoposide-induced cellular senescence of neuronal cells

by myneuronews July 3, 2025

by myneuronews July 3, 2025

Metabolic Alterations in Neuronal Cells Metabolic changes in neuronal cells, particularly during cellular senescence, play …

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Head injuries in intimate partner violence: cognitive, motor, and psychiatric symptoms
CONCLUSION: IPV groups reported more health issues than controls, and those with IPV-HI had the greatest rates of general health, cognitive, psychiatric, and neurobehavioral difficulties. These findings provide novel insight into IPV and IPV-related head injury outcomes.
The exercise and concussion health study (TECHS): Pilot and feasibility protocol
Mild traumatic brain injury (mTBI) is a prevalent neurological condition, affecting millions worldwide, and frequently resulting in persistent cognitive impairment that significantly impacts daily functioning. Current clinical management and recommendations lack evidence based therapeutic interventions, with treatment approaches limited to symptom monitoring and activity modification. Non-pharmaceutical interventions are needed to promote cognitive recovery and mitigate […]
Predictors of two consecutive knockout losses in ultimate fighting championship athletes
CONCLUSIONS: Among UFC athletes during this 8-year period, 23% sustained two knockout losses in a row. Predictors of two consecutive knockouts were older age, male sex, heavier weight class, and prior KO history, with prior KO history the only independent predictor. Recognizing prior knockout exposure as a key risk factor may help coaches and sports […]
Investigating associations between serum inflammatory cytokines at the time of second mild traumatic brain injury with acute neurological signs, axonal injury and behavioural outcomes in male Sprague-Dawley rats
Mild traumatic brain injury is a risk factor to sustaining future mild traumatic brain injuries and increased symptom severity and duration following a second mild traumatic brain injury. Inflammation during neurobiological recovery is hypothesized to influence susceptibility to poorer outcomes after repetitive mild traumatic brain injury. Here, we investigated whether the inflammatory response during neurobiological […]
Quantifying Mechanical Strain-Induced Membrane Damage in Early Neuronal Cells Using an In Vitro Traumatic Brain Injury Model
This protocol describes a reproducible workflow for modeling in vitro impact-induced traumatic brain injury (TBI) using a mechanical stretch system applied to differentiated SH-SY5Y human neuroblastoma cells cultured on polydimethylsiloxane (PDMS) substrates. The protocol integrates three primary components: (1) fabrication and surface modification of deformable PDMS chambers to support cellular adhesion, (2) partial differentiation of […]