Tag:

transcriptomics

Functional neurological disorders
Investigating the role of a novel hemizygous FAAH2 variant in neurological and metabolic disorders

by myneuronews July 31, 2025

by myneuronews July 31, 2025

Role of FAAH2 in Neurological Disorders FAAH2, or fatty acid amide hydrolase 2, is an …

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Functional neurological disorders
Integrated Single-Cell and Spatial Transcriptomic Analysis Identifies ISR-Related Genes Driving Immune Regulation in Parkinson’s Disease

by myneuronews July 21, 2025

by myneuronews July 21, 2025

Integrated Transcriptomic Approaches The integration of transcriptomic approaches offers a powerful way to glean insights …

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Dementia
Metabolic changes in the one-carbon metabolism-related amino acids during etoposide-induced cellular senescence of neuronal cells

by myneuronews July 3, 2025

by myneuronews July 3, 2025

Metabolic Alterations in Neuronal Cells Metabolic changes in neuronal cells, particularly during cellular senescence, play …

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Headaches
Changes in metabolite profiles in the cerebrospinal fluid and in human neuronal cells upon tick-borne encephalitis virus infection

by myneuronews June 14, 2025

by myneuronews June 14, 2025

Metabolite Profile Changes Upon infection with the tick-borne encephalitis virus (TBEV), significant alterations occur in …

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Traumatic brain injury
Single-nucleus and spatial signatures of the brainstem in normal brain and mild traumatic brain injury in male mice

by myneuronews May 31, 2025

by myneuronews May 31, 2025

Study Overview This investigation delves into the complexities of brainstem alterations in male mice, specifically …

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Traumatic brain injury
Single-nucleus and spatial signatures of the brainstem in normal brain and mild traumatic brain injury in male mice

by myneuronews May 31, 2025

by myneuronews May 31, 2025

Study Overview The research investigates the brainstem’s cellular and molecular properties in male mice, specifically …

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Functional neurological disorders
Developing a disease-specific accessible transcriptional signature as a biomarker for ataxia with oculomotor apraxia type 2

by myneuronews May 24, 2025

by myneuronews May 24, 2025

Background of Ataxia with Oculomotor Apraxia Type 2 Ataxia with oculomotor apraxia type 2 (AOA2) …

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Traumatic brain injury
Single-Cell RNA and Transcriptome Sequencing to Analyze the Role of Lactate Metabolism in Traumatic Brain Injury Astrocytes

by myneuronews May 21, 2025

by myneuronews May 21, 2025

Role of Lactate Metabolism in Astrocytes Lactate metabolism plays a pivotal role in cellular energy …

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Functional neurological disorders
Scar-associated macrophages and biliary epithelial cells interaction exacerbates hepatic fibrosis in biliary atresia

by myneuronews May 18, 2025

by myneuronews May 18, 2025

Mechanisms of Macrophage and Biliary Epithelial Cell Interaction The interaction between macrophages and biliary epithelial …

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Functional neurological disorders
Spatial Multiomics Toward Understanding Neurological Systems

by myneuronews May 13, 2025

by myneuronews May 13, 2025

Understanding Spatial Multiomics Spatial multiomics is revolutionizing our understanding of the brain and its complex …

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Impact of oxygen and carbon dioxide levels on mortality in moderate to severe traumatic brain injury: a systematic review and meta-analysis
CONCLUSIONS: In adults with msTBI, hypoxia and hypocapnia were independently associated with increased mortality, underscoring the importance of prompt recognition and targeted management of these secondary injuries. The role of hypercapnia remains unclear, warranting further investigation.
Construction of a predictive model for hospital-acquired pneumonia risk in patients with mild traumatic brain injury based on LASSO-Logistic regression analysis
CONCLUSIONS: The cause of injury being a traffic accident, NEUT, ESR, FBG, PT, APTT, Alb, BUN, and Na^(+) are identified as major risk factors influencing the occurrence of HAP in mTBI patients. The prediction model constructed using these parameters effectively assesses the likelihood of HAP in mTBI patients.
Curcumin-Rich Curry Consumption Is Associated with Lower Risk of Cognitive Decline and Incidence of Mild Cognitive Impairment or Dementia: An Asian Population-Based Study
CONCLUSIONS: The intake of dietary curcumin through curry shows a dose-dependent reduction in incidence of cognitive decline and MCI-dementia in this Asian population of community-based elders.
Sensitivity of Diffusion Tensor Imaging for Assessing Injury Severity in a Rat Model of Isolated Diffuse Axonal Injury: Comparison with Histology and Neurological Assessment
Diffuse axonal brain injury (DAI) is a common, debilitating consequence of traumatic brain injury, yet its detection and severity grading remain challenging in clinical and experimental settings. This study evaluated the sensitivity of diffusion tensor imaging (DTI), histology, and neurological severity scoring (NSS) in assessing injury severity in a rat model of isolated DAI. A […]
The Effect of Intracellular Calcium Buffer Bapta on Epileptiform Activity of Hippocampal Neurons
The rhythm of epileptiform activity occurs in various brain injuries (ischemia, stroke, concussion, mechanical damage, AD, PD). The epileptiform rhythm is accompanied by periodic Ca^(2+) pulses, which are necessary for the neurotransmitter release, the repair of damaged connections between neurons, and the growth of new projections. The duration and amplitude of these pulses depend on […]