Tag:

transcriptomics

Traumatic brain injury
CCL5/RANTES signaling in inflammation dysregulation after mild traumatic brain injury

by myneuronews January 8, 2026

by myneuronews January 8, 2026

CCL5/RANTES Role in Brain Injury CCL5, also known as RANTES (Regulated upon Activation, Normal T …

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Traumatic brain injury
Biomarkers

by myneuronews December 26, 2025

by myneuronews December 26, 2025

Biomarker Definition and Types Biomarkers are biological indicators that provide measurable evidence of specific physiological …

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Dementia
Biomarkers

by myneuronews December 25, 2025

by myneuronews December 25, 2025

Biomarker Definition and Types Biomarkers are biological indicators that are used to measure and evaluate …

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Dementia
Consideration of sex as a biological variable over the history of the 5xFAD Alzheimer’s Disease mouse model

by myneuronews December 17, 2025

by myneuronews December 17, 2025

Biological Considerations When investigating Alzheimer’s disease through animal models, particularly the 5xFAD mouse model, it …

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Traumatic brain injury
Ferroptosis-Mediated Hippocampal Neuronal Loss Post-mTBI: Chromatin Accessibility Profiling and Single-Nucleus Transcriptomics

by myneuronews December 15, 2025

by myneuronews December 15, 2025

Study Overview This research explores the phenomenon of ferroptosis, a form of regulated cell death …

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Traumatic brain injury
Ferroptosis-Mediated Hippocampal Neuronal Loss Post-mTBI: Chromatin Accessibility Profiling and Single-Nucleus Transcriptomics

by myneuronews December 15, 2025

by myneuronews December 15, 2025

Research Context The brain is a complex organ with numerous cellular interactions, and understanding these …

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Traumatic brain injury
Mechanisms of naozhenning in inhibiting neuronal ferroptosis and alleviating brain recurrent mild traumatic brain injury in a rat model

by myneuronews December 4, 2025

by myneuronews December 4, 2025

Mechanisms of Ferroptosis Inhibition Ferroptosis is a distinct form of regulated cell death characterized by …

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Dementia
Single-nucleus and spatial transcriptomic profiling of human temporal cortex and white matter reveals key associations with AD pathology

by myneuronews November 24, 2025

by myneuronews November 24, 2025

Study Overview This study centers on the intricate relationships between cellular profiles in the human …

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Traumatic brain injury
Metabolomics of cerebrospinal fluid following traumatic brain injury: Exploration of biomarkers for secondary injuries and severity

by myneuronews November 14, 2025

by myneuronews November 14, 2025

Metabolomic Profiling Metabolomic profiling involves the comprehensive analysis of metabolites—small molecules that are the end …

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Dementia
Metabolic changes in the one-carbon metabolism-related amino acids during etoposide-induced cellular senescence of neuronal cells

by myneuronews July 3, 2025

by myneuronews July 3, 2025

Metabolic Alterations in Neuronal Cells Metabolic changes in neuronal cells, particularly during cellular senescence, play …

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National and subnational burden of neurological disorders in Iran, 1990 to 2021: results from the global burden of disease study 2021
Burden of Neurological Disorders in Iran The landscape of neurological disorders in Iran presents a…
Nuclear membrane disruption in neurodegenerative diseases: Emerging perspectives
Nuclear membrane function in neuronal health The nuclear membrane, or nuclear envelope, is a critical…
Cognitive impairment and altered structural connectivity after mild traumatic brain injury: A longitudinal study based on generalized q-sampling imaging
Cognitive Impairment Assessment The assessment of cognitive impairment following mild traumatic brain injury (mTBI) is…
Prevalence and Risk of Anxiety and Depression after Concussion: A TRANSCENDENT Study
Study Overview The investigation focused on the prevalence and risk factors associated with anxiety and…
Inhibition of p38 MAPK after repetitive mTBI ameliorates immune signaling and functional deficits
Study Overview This study investigates the effects of inhibiting p38 MAPK (mitogen-activated protein kinase) following…

NSAID Use Is Not Associated With Persisting Symptoms in Adolescent Concussion
CONCLUSIONS: In adolescents, NSAID use was associated with more severe symptoms but not PSaC. To optimize clinical guidance, future research should further evaluate the role of NSAIDs in concussion recovery.
Reduced cortical excitability is associated with head impact severity and cognitive symptoms in adolescent football players
American tackle football is associated with high rates of concussion, leading to neurophysiological disturbances and debilitating clinical symptoms, but previous investigations have largely ignored aperiodic neurophysiological activity. In this study, we use pre- and post-season resting-state magnetoencephalography (MEG) to examine whether concussion during a season of football is related to changes in neurophysiology and whether […]
Severity of physical, emotional, and cognitive symptoms is associated with future persistence of acute post-traumatic headache attributed to mild traumatic brain injury
AimPost-traumatic headache (PTH) attributed to mild traumatic brain injury (mTBI) frequently co-occurs with other physical, cognitive, and emotional symptoms. This study assessed associations between PTH improvement and these symptoms in individuals with acute headaches (APTH) and compared symptoms between those who had recently developed persistent PTH (PPTH) to those who had long-standing PPTH.MethodsThis study included […]
Sex hormone dysregulation after traumatic brain injury: interactions with sleep disturbances and seizure susceptibility
Each year, approximately 2.9 million people in the United States sustain a traumatic brain injury (TBI), many of whom go on to experience chronic secondary complications such as post-traumatic epilepsy (PTE) and sleep-wake disturbances. These outcomes arise from complex secondary injury processes, including neuroinflammation, oxidative stress, and disruptions in neuroendocrine signaling. While inflammatory and excitotoxic […]
Systemic inflammation and its associations in acute moderate-severe Traumatic Brain Injury: a cross-sectional study
Traumatic Brain Injury (TBI) triggers an acute systemic inflammatory response, which may impact outcomes. This response may interact with pre-existing factors linked to inflammation, such as age, to influence outcomes. Previous studies have typically measured few cytokines, but high-dimensional proteomic approaches can sensitively detect a broad range of inflammatory markers, to better characterise post-TBI inflammation. […]