Tag:

transcriptomics

Traumatic brain injury
CCL5/RANTES signaling in inflammation dysregulation after mild traumatic brain injury

by myneuronews January 8, 2026

by myneuronews January 8, 2026

CCL5/RANTES Role in Brain Injury CCL5, also known as RANTES (Regulated upon Activation, Normal T …

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Traumatic brain injury
Biomarkers

by myneuronews December 26, 2025

by myneuronews December 26, 2025

Biomarker Definition and Types Biomarkers are biological indicators that provide measurable evidence of specific physiological …

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Dementia
Biomarkers

by myneuronews December 25, 2025

by myneuronews December 25, 2025

Biomarker Definition and Types Biomarkers are biological indicators that are used to measure and evaluate …

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Dementia
Consideration of sex as a biological variable over the history of the 5xFAD Alzheimer’s Disease mouse model

by myneuronews December 17, 2025

by myneuronews December 17, 2025

Biological Considerations When investigating Alzheimer’s disease through animal models, particularly the 5xFAD mouse model, it …

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Traumatic brain injury
Ferroptosis-Mediated Hippocampal Neuronal Loss Post-mTBI: Chromatin Accessibility Profiling and Single-Nucleus Transcriptomics

by myneuronews December 15, 2025

by myneuronews December 15, 2025

Study Overview This research explores the phenomenon of ferroptosis, a form of regulated cell death …

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Traumatic brain injury
Ferroptosis-Mediated Hippocampal Neuronal Loss Post-mTBI: Chromatin Accessibility Profiling and Single-Nucleus Transcriptomics

by myneuronews December 15, 2025

by myneuronews December 15, 2025

Research Context The brain is a complex organ with numerous cellular interactions, and understanding these …

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Traumatic brain injury
Mechanisms of naozhenning in inhibiting neuronal ferroptosis and alleviating brain recurrent mild traumatic brain injury in a rat model

by myneuronews December 4, 2025

by myneuronews December 4, 2025

Mechanisms of Ferroptosis Inhibition Ferroptosis is a distinct form of regulated cell death characterized by …

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Dementia
Single-nucleus and spatial transcriptomic profiling of human temporal cortex and white matter reveals key associations with AD pathology

by myneuronews November 24, 2025

by myneuronews November 24, 2025

Study Overview This study centers on the intricate relationships between cellular profiles in the human …

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Traumatic brain injury
Metabolomics of cerebrospinal fluid following traumatic brain injury: Exploration of biomarkers for secondary injuries and severity

by myneuronews November 14, 2025

by myneuronews November 14, 2025

Metabolomic Profiling Metabolomic profiling involves the comprehensive analysis of metabolites—small molecules that are the end …

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Dementia
Metabolic changes in the one-carbon metabolism-related amino acids during etoposide-induced cellular senescence of neuronal cells

by myneuronews July 3, 2025

by myneuronews July 3, 2025

Metabolic Alterations in Neuronal Cells Metabolic changes in neuronal cells, particularly during cellular senescence, play …

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Blood Glucose as a Prognostic Predictor of Traumatic Brain Injury in Patients That Underwent Surgical Intervention
CONCLUSION: Elevated initial blood glucose levels were associated with poorer outcomes in patients with TBI, especially in those with moderate TBI. Further research, including larger multicenter studies, is needed to validate our findings and explore optimal glucose management strategies.
Lower limb injuries and concussions dominate in collegiate women's ice hockey: a systematic review and meta-analysis
CONCLUSION: The overall injury incidence in collegiate-level women's ice hockey is considerable, with lower limb injuries being the most common injury location and concussions the most frequent injury type. This review establishes a baseline for injury patterns in women's collegiate ice hockey prior to the potential legalisation of body checking in all levels of women's […]
Loss of CAMKK2 and iron-transport proteins-transferrin and its receptor-in the Alzheimer's disease hippocampus: link to tau pathology
INTRODUCTION: Calcium and iron are essential bioelements regulating neuronal function and survival. Dysregulation of calcium signaling and iron homeostasis is implicated in Alzheimer's disease (AD), contributing to oxidative stress, synaptic dysfunction, and neurodegeneration. Previously, using in vitro cell-based models and transgenic mice, we demonstrated that CAMKK2, a calcium/calmodulin-dependent protein kinase, regulates iron transport via transferrin […]
The Effect of Aerobic Exercise on Post-concussion Recovery in Athletes: A Narrative Review
Traumatic brain injuries (TBIs), in particular sports-related concussions (SRCs), are a significant health concern for young athletes in the United States. Historically, treatment has consisted of prolonged physical and cognitive rest, requiring athletes to abstain from activity until symptoms resolve and physician clearance is obtained. However, emerging evidence suggests that the early introduction of light […]
Cortical spreading depression and multi-territorial cortical infarction following traumatic subdural hematoma: A case report and literature review
CONCLUSION: This case highlights the potential contribution of CSD, inferred from characteristic imaging findings, and spreading ischemia to delayed, diffuse hemispheric infarction in the setting of traumatic SDH, emphasizing its pathophysiological mechanisms, diagnostic challenges, and therapeutic implications.