Biomarkers
Biomarker Definition and Types Biomarkers are biological indicators that are used to measure and evaluate various physiological and pathological processes […]
Consideration of sex as a biological variable over the history of the 5xFAD Alzheimer’s Disease mouse model
Biological Considerations When investigating Alzheimer’s disease through animal models, particularly the 5xFAD mouse model, it is crucial to acknowledge the
Ferroptosis-Mediated Hippocampal Neuronal Loss Post-mTBI: Chromatin Accessibility Profiling and Single-Nucleus Transcriptomics
Study Overview This research explores the phenomenon of ferroptosis, a form of regulated cell death distinct from apoptosis, in the
Ferroptosis-Mediated Hippocampal Neuronal Loss Post-mTBI: Chromatin Accessibility Profiling and Single-Nucleus Transcriptomics
Research Context The brain is a complex organ with numerous cellular interactions, and understanding these dynamics is critical for addressing
Mechanisms of naozhenning in inhibiting neuronal ferroptosis and alleviating brain recurrent mild traumatic brain injury in a rat model
Mechanisms of Ferroptosis Inhibition Ferroptosis is a distinct form of regulated cell death characterized by an accumulation of lipid peroxides
Single-nucleus and spatial transcriptomic profiling of human temporal cortex and white matter reveals key associations with AD pathology
Study Overview This study centers on the intricate relationships between cellular profiles in the human brain’s temporal cortex and white
Metabolomics of cerebrospinal fluid following traumatic brain injury: Exploration of biomarkers for secondary injuries and severity
Metabolomic Profiling Metabolomic profiling involves the comprehensive analysis of metabolites—small molecules that are the end products of cellular processes—in biological
Metabolic changes in the one-carbon metabolism-related amino acids during etoposide-induced cellular senescence of neuronal cells
Metabolic Alterations in Neuronal Cells Metabolic changes in neuronal cells, particularly during cellular senescence, play a crucial role in understanding
Changes in metabolite profiles in the cerebrospinal fluid and in human neuronal cells upon tick-borne encephalitis virus infection
Metabolite Profile Changes Upon infection with the tick-borne encephalitis virus (TBEV), significant alterations occur in the metabolite profiles of both
Single-nucleus and spatial signatures of the brainstem in normal brain and mild traumatic brain injury in male mice
Study Overview This investigation delves into the complexities of brainstem alterations in male mice, specifically focusing on instances of normal