Astasia-Abasia Syndrome

April 24, 2025

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The Gatekeeper’s Dilemma: Why Sustainable Functional/Dissociative Seizure Care Begins With Referral
Understanding Functional/Dissociative Seizures Functional or dissociative seizures, often referred to as psychogenic non-epileptic seizures (PNES), present a unique challenge within the realm of neurology and psychiatry. Unlike epileptic seizures, which are characterized by abnormal electrical activity in the brain, functional seizures stem from psychological rather than neurological origins. Patients may experience symptoms such as uncontrollable… Read more: The Gatekeeper’s Dilemma: Why Sustainable Functional/Dissociative Seizure Care Begins With Referral
The Gatekeeper’s Dilemma: Why Sustainable Functional/Dissociative Seizure Care Begins With Referral
Understanding Functional/Dissociative Seizures Functional or dissociative seizures are episodes that resemble epileptic seizures but do not stem from the typical electrical disturbances in the brain. Instead, these seizures are closely linked to psychological factors and often manifest as a response to stress, trauma, or emotional distress. Clinically, they can be characterized by a range of… Read more: The Gatekeeper’s Dilemma: Why Sustainable Functional/Dissociative Seizure Care Begins With Referral
LRP1 in Ischemic Stroke: From CNS Homeostasis to Ischemic Injury and Repair
Role of LRP1 in CNS Homeostasis Low-density lipoprotein receptor-related protein 1 (LRP1) plays a critical role in maintaining central nervous system (CNS) homeostasis through various mechanisms, primarily involving lipid metabolism, clearance of proteins, neurotransmitter transport, and modulation of signaling pathways. LRP1 is predominantly expressed in neurons, astrocytes, and microglia, enabling it to influence multiple cell… Read more: LRP1 in Ischemic Stroke: From CNS Homeostasis to Ischemic Injury and Repair
Transitioning from efgartigimod to tacrolimus in chronic inflammatory demyelinating polyneuropathy: a prospective case series
Study Overview The research focuses on the transition of patients with chronic inflammatory demyelinating polyneuropathy (CIDP) from efgartigimod, a neonatal Fc receptor antagonist that selectively reduces pathogenic IgG antibodies, to tacrolimus, a robust immunosuppressant commonly used in various autoimmune conditions. CIDP is characterized by progressive weakness and sensory loss due to nerve damage, and effective… Read more: Transitioning from efgartigimod to tacrolimus in chronic inflammatory demyelinating polyneuropathy: a prospective case series
Microglial handling of myelin debris and remyelination after ischaemic stroke: recognition, intracellular processing, lipid fate, and oligodendroglial repair
Microglial Functions in Myelin Debris Clearance Microglia are the primary immune cells of the central nervous system (CNS), and they play a crucial role in maintaining homeostasis, especially following acute injury such as ischaemic stroke. When there is a disruption in cerebral blood flow, neuronal death occurs, often resulting in damage to the myelin sheaths… Read more: Microglial handling of myelin debris and remyelination after ischaemic stroke: recognition, intracellular processing, lipid fate, and oligodendroglial repair

Metabolomics in Mild Traumatic Brain Injury: A Scoping Review
Mild traumatic brain injury (mTBI) accounts for around 80-90% of TBI cases, is increasing in incidence, and represents a major public health concern. Despite its high incidence, mTBI lacks reliable molecular biomarkers for diagnosis or prognosis. Metabolomics, the profiling of small-molecule metabolites (≤1 kDa), has emerged as a promising approach to characterize acute neurometabolic perturbations […]
Emergency Department Feasibility of the Brief Test of Adult Cognition by Telephone (BTACT) for Research in Mild Traumatic Brain Injury
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Patient and Provider Perspective of Cranioelectrical Stimulation for the Management of Persistent Mild Traumatic Brain Injury Symptoms in Veterans and Service Members
CONCLUSION: CES should be considered for nonpharmacologic intervention for managing chronic mTBI symptoms. Enhanced patient education and comprehensive clinician training could improve its effectiveness and adoption. Further research and structured guidance are necessary to maximize the benefits of CES in mTBI care.
Over-the-counter analgesics improve postconcussion symptoms and recovery: findings from the Concussion Assessment, Research and Education (CARE) Consortium
CONCLUSIONS: This study shows that OTC analgesic use postinjury is associated with lower symptom severity and a faster recovery after concussion.
Estimating Linear and Rotational Head Kinematics in Ice Hockey from a Single Helmet-Mounted IMU Using Vector Autoregressive Models
CONCLUSION: In conclusion, the VAR modeling framework offers a promising multivariate approach for reconstructing head impact kinematics from a single IMU-instrumented helmet. However, limited generalization to higher, untrained intensities highlights the need for further development before real-time head injury assessment can be supported.

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