Astasia-Abasia Syndrome

April 24, 2025

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Validation of a human peripheral neuronal model for ATP-P2X3 mediated inflammatory pain signalling in the dental pulp
Study Overview This research investigates the role of ATP and its interaction with the P2X3 receptor in mediating inflammatory pain signals within human peripheral neurons, specifically in the context of dental pulp. The motivation behind this study stems from the significant burden of dental pain and its underlying mechanisms, which often involve the activation of… Read more: Validation of a human peripheral neuronal model for ATP-P2X3 mediated inflammatory pain signalling in the dental pulp
Tack Number as an Independent Predictor of Recurrence after TEP Repair: A Multicenter Retrospective ROC-Based Study
Tack Number as a Prognostic Factor Tack number, referring to the quantity of tacks used during a transabdominal preperitoneal (TEP) hernia repair, has emerged as an important factor in evaluating postoperative outcomes. The hypothesis driving this analysis is that the number of tacks utilized could correlate with the likelihood of hernia recurrence. Previous studies have… Read more: Tack Number as an Independent Predictor of Recurrence after TEP Repair: A Multicenter Retrospective ROC-Based Study
Validation of a human peripheral neuronal model for ATP-P2X3 mediated inflammatory pain signalling in the dental pulp
Study Overview This research investigates the role of ATP signaling via the P2X3 receptor in the context of inflammatory pain that originates in the dental pulp. The dental pulp, a soft tissue found within the tooth, can become inflamed due to various dental conditions, leading to significant discomfort. Understanding the mechanisms behind this pain is… Read more: Validation of a human peripheral neuronal model for ATP-P2X3 mediated inflammatory pain signalling in the dental pulp
NAD+ supplementation and PARP inhibition following spinal cord injury in mice: Hurdles and considerations for therapeutic use
Study Overview The study focused on the implications of NAD+ supplementation and PARP (poly(ADP-ribose) polymerase) inhibition following spinal cord injury (SCI) in mouse models. It aimed to explore how enhancing NAD+ levels and inhibiting PARP activity could influence the recovery processes following traumatic spinal injury. Previous research has indicated that both NAD+ and PARP have… Read more: NAD+ supplementation and PARP inhibition following spinal cord injury in mice: Hurdles and considerations for therapeutic use
Genetic subtypes of multiple sclerosis severity are uncoupled from inflammatory lesion burden
Genetic Subtype Identification Identifying genetic subtypes of multiple sclerosis (MS) is a pivotal aspect of understanding the heterogeneity of the disease and its impact on patient outcomes. Researchers have increasingly recognized that MS is not a single disorder but a complex interplay of various genetic factors that influence its presentation and progression. Genetic analysis has… Read more: Genetic subtypes of multiple sclerosis severity are uncoupled from inflammatory lesion burden

Associations between sleep disturbances and concussions in US high school athletes
CONCLUSIONS: A dose-response association was observed between the self-reported concussion history and the shorter self-reported sleep duration among high school athletes. The long-term clinical implications of these modest differences in sleep duration remain uncertain and warrant further investigation. Future longitudinal studies utilizing objective sleep and validated concussion assessments are needed to assess the long-term effects […]
Hemispheric asymmetries in rodent models of neurological diseases: a systematic review
INTRODUCTION: Hemispheric asymmetries are a core organizational principle of the vertebrate brain, but they are still not fully integrated into the study of preclinical models of neurological disease. Although many rodent models naturally include lateralization through unilateral interventions, hemispheric differences are not consistently examined or systematically reported.
Interaction of Rifle Discharge Overpressure and Recoil Effects on Brain Response Quantified with Finite Element Head Model
CONCLUSION: The results from the study have quantified the magnitudes and relative timings of overpressure and recoil kinematics loadings to the head during a single LPR discharge and can be used to guide prevention and mitigation strategies for operators.
What every dentist needs to know about the risk of pickleball-related injuries to the head and neck
Since the inception of pickleball in 1965, approximately 19% of the US population has engaged in the sport. Although pickleball was initially intended as a safe activity for children, the vast majority of players are older adults. Within the last 5 years, there has been a conspicuous surge in pickleball-related injuries. The objective of this […]
Mapping concussion-induced cerebellar injury: a personalized approach using diffusion tensor imaging (DTI)
OBJECTIVE: We investigated the potential of diffusion tensor imaging (DTI) in identifying alterations in cerebellar white matter (WM) in concussion patients. We hypothesized that DTI, combined with a Z-score analysis approach, could provide personalized assessment of cerebellar changes in these patients.

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