Tag:

genetic predisposition

Traumatic brain injury
Persistent Post-concussion syndrome: pathophysiology, diagnosis, current and evolving treatment strategies

by myneuronews June 7, 2025

by myneuronews June 7, 2025

Pathophysiology of Post-concussion Syndrome Post-concussion syndrome (PCS) is a complex disorder that can arise following …

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Functional neurological disorders
Recognising and managing functional neurological disorder in the acute healthcare setting

by myneuronews May 29, 2025

by myneuronews May 29, 2025

Understanding Functional Neurological Disorder Functional Neurological Disorder (FND) represents a fascinating convergence of neurology and …

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Functional neurological disorders
Penetrance of neurodevelopmental copy number variants is associated with variations in cortical morphology

by myneuronews May 25, 2025

by myneuronews May 25, 2025

Understanding Neurodevelopmental Copy Number Variants Neurodevelopmental copy number variants (CNVs) are structural alterations in the …

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Functional neurological disorders
Penetrance of neurodevelopmental copy number variants is associated with variations in cortical morphology

by myneuronews May 25, 2025

by myneuronews May 25, 2025

Neurodevelopmental Variants and Penetrance Neurodevelopmental copy number variants (CNVs) represent significant alterations in an individual’s …

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Functional neurological disorders
A Narrative Review of Pemphigoid Diseases: Bridging Associations, Comorbidities, and Management

by myneuronews May 24, 2025

by myneuronews May 24, 2025

Overview of Pemphigoid Diseases Pemphigoid diseases are a group of rare autoimmune conditions primarily characterized …

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Functional neurological disorders
HSD17B1-mediated trophoblast differentiation lowers estrogen levels in early-onset preeclampsia

by myneuronews May 20, 2025

by myneuronews May 20, 2025

HSD17B1 Role in Trophoblast Differentiation The study of HSD17B1 (Hydroxysteroid Dehydrogenase Type 1) highlights its …

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Functional neurological disorders
Whole-exome sequencing identifies 5 novel genes associated with carpal tunnel syndrome

by myneuronews May 17, 2025

by myneuronews May 17, 2025

Whole-exome sequencing methodology Whole-exome sequencing (WES) is a powerful genomic tool that has enabled researchers …

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Functional neurological disorders
Psychiatric genome-wide association study enrichment shows promise for future psychopharmaceutical discoveries

by myneuronews May 16, 2025

by myneuronews May 16, 2025

Psychiatric Genome-Wide Association Study Findings The latest findings from psychiatric genome-wide association studies (GWAS) provide …

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Traumatic brain injury
Traumatic brain injury graphing: A case study of Charles Whitman

by myneuronews May 15, 2025

by myneuronews May 15, 2025

Case Background In August 1966, Charles Whitman became infamous for a tragic shooting spree in …

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Functional neurological disorders
Association of APOC1 with cortical atrophy during conversion to Alzheimer’s disease

by myneuronews May 14, 2025

by myneuronews May 14, 2025

Association of Apoc1 with Alzheimer’s Disease Recent research has underscored the significance of the apolipoprotein …

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Interventional Treatment Strategies for Headache and Facial Pain
Interventional Techniques and Approaches Interventional techniques for managing headache and facial pain involve various procedures…
Systematic post-translational modification genome wide identifies therapeutic targets for Alzheimer’s disease: evidence from multi-cohort analysis
Identifying Therapeutic Targets In recent years, identifying therapeutic targets for Alzheimer’s disease (AD) has gained…
Functional Connectivity Gradients Reveal Altered Hierarchical Cortical Organization in Functional Neurological Disorder
Functional Connectivity Analysis Functional connectivity analysis has emerged as a pivotal method for understanding how…
An Intervention to Improve Emotion Regulation in Individuals With Traumatic Brain Injury: A Randomized Controlled Trial
Study Overview This research focused on assessing the effectiveness of a targeted intervention aimed at…
Evolution of Axonal Injury in the Closed Head Impact Model of Engineered Rotational Acceleration in Adult Ferrets
Study Overview This research examines the impact of engineered rotational acceleration on axonal injury in…

SaVeBRAIN.Kids-study protocol for a cluster-randomized stepped-wedge trial to reduce hospitalizations for mild traumatic brain injury in children in Germany
BACKGROUND: Traumatic brain injury (TBI) is one of the most important pediatric conditions worldwide. In Germany, hospitalization rates for mild TBI drastically exceed hospitalization rates from similar healthcare systems.
A Modified Repetitive Closed Head Injury Model Inducing Persistent Neuroinflammation and Functional Deficits Without Extensive Cortical Tissue Destruction
Traumatic brain injury (TBI) remains a significant clinical challenge, with limited treatment options and long-term neurological impairments. Mild to moderate TBI represents the most common form, making it a critical therapeutic target. However, current animal models poorly reflect human TBI pathophysiology, necessitating improved preclinical paradigms. Here, we present a refined repetitive closed head injury (rCHI) […]
Traumatic Microbleeds in Mild Traumatic Brain Injury: Stability, Distribution, and Association with Other Injuries
This study aimed to investigate whether the amount of traumatic microbleeds (TMBs) detected on magnetic resonance imaging (MRI) changes in different brain regions after a 3-month follow-up in adult patients with mild traumatic brain injury (mTBI). A 3 T MRI of the brain was conducted at baseline (3-17 days after trauma) and at 3 months […]
An Intervention to Improve Emotion Regulation in Individuals With Traumatic Brain Injury: A Randomized Controlled Trial
CONCLUSIONS: Evidence supports the efficacy of Online EmReg to improve ER following TBI.
Evolution of Axonal Injury in the Closed Head Impact Model of Engineered Rotational Acceleration in Adult Ferrets
Concussion-related symptoms, such as impaired balance, slower processing speed, attention deficits, memory dysfunction, and irritability, are thought to result from diffuse axonal injury (DAI), characterized by selective damage to white matter axons. Axons subjected to this mechanical stretch injury exhibit diverse pathological changes, including disruption of axonal transport, neurofilament compaction and degradation, myelin sheath disruption, […]