Tag:

human brain

Dementia
Single-nucleus and spatial transcriptomic profiling of human temporal cortex and white matter reveals key associations with AD pathology

by myneuronews November 24, 2025

by myneuronews November 24, 2025

Study Overview This study centers on the intricate relationships between cellular profiles in the human …

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Dementia
Polygenic risk score of Alzheimer’s disease is associated with cognitive trajectories and phenotypes of cerebral organoids

by myneuronews September 17, 2025

by myneuronews September 17, 2025

Study Overview This study investigates the relationship between polygenic risk scores (PRS) for Alzheimer’s disease …

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Traumatic brain injury
Concussive injuries induce neuronal stress-dependent tau mislocalization to dendritic spines with acrolein and functional network alteration in TBI-on-a-chip

by myneuronews September 11, 2025

by myneuronews September 11, 2025

Study Overview This research focuses on the cellular mechanisms involved in concussive injuries, specifically examining …

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Functional neurological disorders
Mechanisms of motor dysfunction in functional neurological disorder: A narrative review

by myneuronews September 6, 2025

by myneuronews September 6, 2025

Overview of Functional Neurological Disorder Functional Neurological Disorder (FND) encompasses a range of neurological symptoms …

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Dementia
High-affinity transferrin receptor binding improves brain delivery of bispecific antibodies at tracer dose

by myneuronews August 22, 2025

by myneuronews August 22, 2025

Study Overview The research focused on improving the delivery of bispecific antibodies to the brain. …

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Traumatic brain injury
Get Your Brain in the Game: Using Machine Learning to Predict Recovery Timelines Following Sports-Related Concussion

by myneuronews July 21, 2025

by myneuronews July 21, 2025

Study Overview The research conducted aimed to investigate how machine learning can be utilized to …

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Functional neurological disorders
Analysis of biased allelic enhancer activity of schizophrenia-linked common variants

by myneuronews July 10, 2025

by myneuronews July 10, 2025

Biased allelic enhancer activity in schizophrenia Recent findings have highlighted the complexity of genetic factors …

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Traumatic brain injury
Advancing next-generation brain organoid platforms for investigating traumatic brain injury from repeated blast exposures

by myneuronews July 3, 2025

by myneuronews July 3, 2025

Study Overview The research investigates the utilization of advanced brain organoid platforms to explore the …

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Traumatic brain injury
Cannabidiol inhibits neuronal endoplasmic reticulum stress and apoptosis in rats with multiple concussions by regulating the PERK-eIF2alpha-ATF4-CHOP pathway

by myneuronews June 27, 2025

by myneuronews June 27, 2025

Neuronal Endoplasmic Reticulum Stress and Apoptosis The endoplasmic reticulum (ER) plays a crucial role in …

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Traumatic brain injury
Erratum: Modified Mouse Model of Repetitive Mild Traumatic Brain Injury Incorporating Thinned-Skull Window and Fluid Percussion

by myneuronews June 4, 2025

by myneuronews June 4, 2025

Study Overview The research presented focuses on the development and validation of an advanced animal …

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Acupuncture for Mild Traumatic Brain Injury: A Call for Deeper Analysis of Symptoms and Scans
No abstract
The Intensive Stroke Cycling for Optimal Recovery and Economic Value Trial (I-SCORE): Protocol for a Randomized Clinical Trial
IMPORTANCE: Current rehabilitative approaches for the recovery of upper (UE) and lower extremity (LE) function following stroke involve costly time- and personnel-intensive 1-on-1 motor learning-based training. Preliminary data in chronic stroke indicate facilitated aerobic exercise (FE), where volitional LE movements are mechanically supplemented, enhances UE motor recovery associated with task-based practice.
Evaluating R2Play, A Novel Multidomain Return-to-Play Assessment Tool for Concussion: Mixed Methods Feasibility and Face Validity Study
CONCLUSIONS: Findings support the potential feasibility and face validity of R2Play, a multidomain assessment tool for youth with concussion, demonstrating excellent usability, vigorous physical exertion demands, and promising feedback regarding its potential to fill gaps in the return-to-play process among this initial sample from a single site. Future work is underway to establish the cross-site […]
Is it time for evidence-based protective strategies for heading in youth football?
No abstract
Orthostatic Tachycardia in Children With and Without Persisting Post-concussion Symptoms Following Mild Traumatic Brain Injury: A Prospective Controlled Study
CONCLUSIONS: Using the Active Stand Test, a small proportion of children with PPCS satisfied clinical POTS criteria. Although it should be considered in the differential diagnosis, POTS is not common nor overrepresented in PPCS.