Tag:

human brain

Dementia
Polygenic risk score of Alzheimer’s disease is associated with cognitive trajectories and phenotypes of cerebral organoids

by myneuronews September 17, 2025

by myneuronews September 17, 2025

Study Overview This study investigates the relationship between polygenic risk scores (PRS) for Alzheimer’s disease …

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Traumatic brain injury
Concussive injuries induce neuronal stress-dependent tau mislocalization to dendritic spines with acrolein and functional network alteration in TBI-on-a-chip

by myneuronews September 11, 2025

by myneuronews September 11, 2025

Study Overview This research focuses on the cellular mechanisms involved in concussive injuries, specifically examining …

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Functional neurological disorders
Mechanisms of motor dysfunction in functional neurological disorder: A narrative review

by myneuronews September 6, 2025

by myneuronews September 6, 2025

Overview of Functional Neurological Disorder Functional Neurological Disorder (FND) encompasses a range of neurological symptoms …

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Dementia
High-affinity transferrin receptor binding improves brain delivery of bispecific antibodies at tracer dose

by myneuronews August 22, 2025

by myneuronews August 22, 2025

Study Overview The research focused on improving the delivery of bispecific antibodies to the brain. …

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Traumatic brain injury
Get Your Brain in the Game: Using Machine Learning to Predict Recovery Timelines Following Sports-Related Concussion

by myneuronews July 21, 2025

by myneuronews July 21, 2025

Study Overview The research conducted aimed to investigate how machine learning can be utilized to …

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Functional neurological disorders
Analysis of biased allelic enhancer activity of schizophrenia-linked common variants

by myneuronews July 10, 2025

by myneuronews July 10, 2025

Biased allelic enhancer activity in schizophrenia Recent findings have highlighted the complexity of genetic factors …

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Traumatic brain injury
Advancing next-generation brain organoid platforms for investigating traumatic brain injury from repeated blast exposures

by myneuronews July 3, 2025

by myneuronews July 3, 2025

Study Overview The research investigates the utilization of advanced brain organoid platforms to explore the …

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Traumatic brain injury
Cannabidiol inhibits neuronal endoplasmic reticulum stress and apoptosis in rats with multiple concussions by regulating the PERK-eIF2alpha-ATF4-CHOP pathway

by myneuronews June 27, 2025

by myneuronews June 27, 2025

Neuronal Endoplasmic Reticulum Stress and Apoptosis The endoplasmic reticulum (ER) plays a crucial role in …

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Traumatic brain injury
Erratum: Modified Mouse Model of Repetitive Mild Traumatic Brain Injury Incorporating Thinned-Skull Window and Fluid Percussion

by myneuronews June 4, 2025

by myneuronews June 4, 2025

Study Overview The research presented focuses on the development and validation of an advanced animal …

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Traumatic brain injury
Sex-dependent blood-brain barrier alterations following repeated mild blast traumatic brain injury at varying inter-injury intervals

by myneuronews June 1, 2025

by myneuronews June 1, 2025

Study Overview The investigation focused on the impact of repeated mild blast traumatic brain injuries …

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First detection of echovirus 18 associated with aseptic meningitis in a child in Niger Republic, 2024: a case report
Background of Echovirus 18 Echovirus 18, part of the Enterovirus genus within the Picornaviridae family,…
Mitochondrial dysfunction, a new marker warning of neuropsychiatric disorder risk: evidence from genetics and epidemiology
Mitochondrial Dysfunction and Neuropsychiatric Disorders Mitochondria, often referred to as the powerhouses of the cell,…
Assessing knowledge and attitudes towards sports-related concussion among university students in Saudi Arabia: a cross-sectional study
Study Overview This research examines the understanding and perceptions surrounding sports-related concussions among university students…
Stabilizing microtubules increases acute cellular injury at high strain rates
Study Overview This study investigates the relationship between the stabilization of microtubules and the susceptibility…
Pre-injury sleep disturbance as a moderator of cognitive functioning in children and adolescents with mild traumatic brain injury
Study Overview The research investigates the complex interplay between pre-injury sleep disturbances and cognitive outcomes…

Factor analysis of neuropsychological attention measures with mild traumatic brain injury patients
This study explored the factor structure of commonly used neuropsychological tests to assess attention in individuals with mild traumatic brain injury (mTBI). Archival data were drawn from 269 patients (63% women; M_age = 47.8, SD = 14.6) seen at a private outpatient clinic between 2018 and 2023. Participants self-identified primarily as White (84%), with additional […]
AQP4 in cerebrospinal fluid correlates with severity and prognosis in moderate to severe traumatic brain injury
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Despite advances in acute care and neurological intensive care units, predicting long-term outcomes for TBI patients remains challenging. Aquaporin-4 (AQP4) has emerged as a potential biomarker for assessing TBI severity and prognosis. Our goal is to evaluate AQP4 as a novel agent […]
Evaluating cognitive performance using cognitive performance using the National Institutes of Health Toolbox Cognitive Battery in children with traumatic brain injury
CONCLUSIONS: The NIH TB-CB detects worse cognitive functioning in children with severe TBI six-twelve months post-injury, largely driven by differences in Fluid Cognition. Our findings suggest the NIH TB-CB may be suitable for monitoring cognition in children with TBI.
Impact of Mild Traumatic Brain Injury on Sleep Patterns in Younger Individuals: A Systematic Review
Concussions or mild traumatic brain injuries (mTBI) are a frequent outcome of contact sports, and adolescents and young adults face a disproportionately higher risk of repeated injury. Prominent sequelae of mTBI observed in younger populations include anxiety, decreased sleep quality, insomnia, and impaired cognitive performance, all of which can extend beyond the acute phase of […]
Post-Traumatic Epilepsy After Mild and Moderate Traumatic Brain Injury: A Narrative Review and Development of a Clinical Decision Tool
CONCLUSIONS: Even in non-severe cases, patients with mild and moderate TBI who exhibit high-risk features remain vulnerable to long-term epileptogenesis. Our proposed tool provides a pragmatic, evidence-based framework for early identification and follow-up planning. Prospective validation studies are needed to confirm its predictive accuracy and optimize its clinical utility.