Tag:

neuroinflammation

Traumatic brain injury
Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer’s disease

by myneuronews July 17, 2025

by myneuronews July 17, 2025

Study Overview The study aimed to explore the genetic underpinnings of Alzheimer’s disease (AD) through …

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Traumatic brain injury
Examining the potential of psilocybin and 5-MeO-DMT as therapeutics for traumatic brain injury

by myneuronews July 16, 2025

by myneuronews July 16, 2025

Therapeutic Mechanisms of Psilocybin and 5-MeO-DMT Psilocybin and 5-MeO-DMT, both naturally occurring psychedelic compounds, have …

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Traumatic brain injury
Brain biomarker profiles vary with semi-synthetic and grain-based diets in healthy and mTBI mice

by myneuronews July 16, 2025

by myneuronews July 16, 2025

Brain Biomarker Profiles Recent studies have highlighted the importance of brain biomarker profiles in understanding …

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Functional neurological disorders
Identifying pyroptosis- and inflammation-related genes in spinal cord injury based on bioinformatics analysis

by myneuronews July 14, 2025

by myneuronews July 14, 2025

Gene Identification Methods To identify genes that play a role in pyroptosis and inflammation following …

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Functional neurological disorders
Role of ALOX5AP in the pathogenesis of cerebral small vessel disease: impact of inflammation and lipid metabolism dysregulation

by myneuronews July 12, 2025

by myneuronews July 12, 2025

Pathophysiological Mechanisms of ALOX5AP The role of ALOX5AP (Arachidonate 5-Lipoxygenase Activating Protein) in the pathogenesis …

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Traumatic brain injury
A one year longitudinal study of cortical myelination changes following pediatric mild traumatic brain injury

by myneuronews July 12, 2025

by myneuronews July 12, 2025

Cortical Myelination Changes Cortical myelination refers to the formation and maturation of myelin sheaths around …

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Functional neurological disorders
Role of ALOX5AP in the pathogenesis of cerebral small vessel disease: impact of inflammation and lipid metabolism dysregulation

by myneuronews July 12, 2025

by myneuronews July 12, 2025

Pathophysiological Mechanisms of ALOX5AP ALOX5AP (Arachidonate 5-Lipoxygenase-Activating Protein) plays a pivotal role in the pathophysiology …

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Functional neurological disorders
Epileptic seizure biophysics: the role of local voltage difference

by myneuronews July 11, 2025

by myneuronews July 11, 2025

Understanding Seizure Mechanisms Seizures are complex neurological events that arise from abnormal electrical activity in …

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Traumatic brain injury
Exploring the Impact of Mitoquinone Supplementation on Glycan Profiles in a Repeated Mild Traumatic Brain Injury Mouse Model

by myneuronews July 10, 2025

by myneuronews July 10, 2025

Study Overview This study investigates the effects of mitoquinone supplementation on glycan profiles in a …

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Functional neurological disorders
Wogonin Inhibits Oxidative Stress in Hypoxia-Induced hCMEC/D3 Cells Through Suppressing CXCL8-Mediated TLR4/NF-κB Pathway

by myneuronews July 4, 2025

by myneuronews July 4, 2025

Mechanism of Wogonin Action Wogonin, a naturally occurring flavonoid derived from the plant Scutellaria baicalensis, …

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Incretin Mimetics as Potential Therapeutics for Concussion and Traumatic Brain Injury: A Narrative Review
Traumatic brain injury (TBI) represents a significant health concern, with an estimated 70 million annual cases worldwide. Mild brain trauma (concussions) is the most common TBI (81%), followed by moderate (11%) and severe (8%). Cytokine release and neuroinflammation after TBI may cause blood-brain barrier and tissue damage, triggering unfavorable outcomes, including disabilities and mortality. Current […]
N-Stearidonoylethanolamine Restores CA1 Synaptic Integrity and Reduces Astrocytic Reactivity After Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI) disrupts hippocampal network function through coordinated alterations in glial reactivity, synaptic integrity, and adult neurogenesis. Effective therapeutic approaches targeting these interconnected processes remain limited. Lipid-derived molecules capable of modulating these mTBI-induced disturbances are emerging as promising neuroprotective candidates. Here, we investigated the effects of N-stearidonylethanolamine (SDEA), an ω-3 ethanolamide, in […]
Effects of persistent post-concussion symptoms on neurocognitive, motor, and neurophysiological outcomes
CONCLUSION: The PPCS group demonstrated greater symptom reporting and severity, worse neurocognitive performance, worse balance and gait performance, and altered neurophysiology. Further, females with PPCS demonstrated worse balance and gait performance compared to all other groups.
Injury-environment interaction: microglial priming by mTBI creates vulnerability to subsequent stress via the HMGB1-RAGE axis
CONCLUSION: Our study untangles a "priming-triggering" mechanism of injury-environment interaction, identifying the HMGB1-RAGE axis as its key molecular mediator. This finding not only enhances our understanding of how latent vulnerability transitions into overt neuropsychiatric disease, but also provides a promising target for preventive intervention.
Relationship between illness perceptions, coping style and post-concussion symptoms after systemic traumatic injury: A comparison of those with and without mild traumatic brain injury
Research has reported variable findings when investigating the relationship between outcome and coping style and illness perceptions after mild traumatic brain injury (mTBI). The present study investigated 138 individuals who had been admitted to hospital after suffering a traumatic systemic injury, with 91 of these individuals also fulfilling criteria for mTBI and 47 comprising a […]