Plumbagin Ameliorates Multiple Sclerosis by Inducing DDX3X-Mediated Stress Granule Assembly in Mice
Therapeutic Effects of Plumbagin Plumbagin, a natural compound derived from the plant genus Plumbago, has garnered significant attention for its […]
Recurrent polychondritis complicated with demyelinating encephalopathy and limbic encephalitis: a case report and literature review
Clinical Presentation Recurrent polychondritis primarily manifests as episodic inflammation of cartilage and connective tissues. Patients often present with symptoms affecting
Bridging Trauma and Parkinson’s Disease: Mechanisms, Models, and Biomarkers of Post-Traumatic Parkinsonism
Trauma and Parkinson’s Disease Connection Trauma, particularly in the form of physical injuries, has been increasingly recognized as a potential
Mechanistic Insights and Therapeutic Potential of MCC950 as a NLRP3 Inflammasome Inhibitor in Multiple Sclerosis: A Narrative Review
Background on NLRP3 Inflammasome The NLRP3 inflammasome represents a crucial component of the innate immune system, acting as a molecular
Mesenchymal stromal cells and neuroinflammation: a multimodal approach to neuroprotection and future therapeutic horizons
Mechanisms of Neuroinflammation Neuroinflammation is a complex biological response observed within the central nervous system (CNS), primarily involving the activation
Impact frequency and interval modulate brain network outcomes in a rat model of repetitive mild traumatic brain injury
Experimental Design The study employed a well-structured experimental framework to investigate the impacts of repetitive mild traumatic brain injury (mTBI)
Fucoxanthin ameliorates experimental autoimmune encephalomyelitis by inhibiting microglial NLRP3 inflammasome
Study Overview The research investigates the effects of fucoxanthin, a natural carotenoid pigment found in brown seaweeds, on experimental autoimmune
Functional and microstructural biomarkers of repetitive mild head injury in a conscious momentum exchange mouse model
Study Overview This study examines the impact of repetitive mild head injuries on brain function and structure, utilizing a mouse
Recognition of dementia as a noncommunicable disease is just the start
Dementia as a Noncommunicable Disease Dementia, encompassing a diverse range of cognitive impairments, has historically been viewed primarily through the
Recognition of dementia as a noncommunicable disease is just the start Read Post »
ISG15/ISGylation in central nervous system diseases: molecular mechanisms and therapeutic targeting
Molecular Mechanisms of ISG15/ISGylation ISG15, or interferon-stimulated gene 15, is a small ubiquitin-like modifier that plays a crucial role in