Tag:

neuroinflammation

Dementia
Differences in inflammatory markers, mitochondrial function, and synaptic proteins in male and female Alzheimer’s disease post mortem brains

by myneuronews October 1, 2025

by myneuronews October 1, 2025

Inflammatory Markers Comparison Research into Alzheimer’s disease has increasingly highlighted the significance of inflammation in …

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Dementia
Maintenance of neuronal TDP-43 expression requires axonal lysosome transport

by myneuronews September 19, 2025

by myneuronews September 19, 2025

Study Overview The investigation centered on understanding the critical role of TDP-43, a protein associated …

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Traumatic brain injury
Cumulative and Contextual Effects of Low-Level Blast Exposure on Cognitive Function in Military Personnel: Interactions With PTSD and Mild TBI

by myneuronews September 19, 2025

by myneuronews September 19, 2025

Cumulative effects of blast exposure The cumulative impact of low-level blast exposure on cognitive abilities …

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Traumatic brain injury
A Semi-Automated and Unbiased Microglia Morphology Analysis Following Mild Traumatic Brain Injury in Rats

by myneuronews September 13, 2025

by myneuronews September 13, 2025

Study Overview This study investigates the morphological changes in microglia, the immune cells of the …

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Traumatic brain injury
Spautin-1 alleviates depression-like behaviors in mice after traumatic brain injury by inhibiting MMP3 expression in microglia in the Hippocampal CA1 region

by myneuronews September 12, 2025

by myneuronews September 12, 2025

Study Overview The research in question investigates the effects of Spautin-1, a compound known for …

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Dementia
Estimated Glucose Disposal Rate and Risk of Stroke and Dementia in Nondiabetics: A UK Biobank Prospective Cohort Study

by myneuronews September 11, 2025

by myneuronews September 11, 2025

Study Overview The investigation centered around the relationship between glucose disposal rate and the risk …

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Traumatic brain injury
CD300f enables microglial damage sensing, efferocytosis, and apoptotic cell metabolization after brain injury

by myneuronews September 11, 2025

by myneuronews September 11, 2025

Microglial Function in Brain Injury Microglia, the primary immune cells of the central nervous system, …

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Dementia
Boston University Alzheimer’s Disease Research Center Clinical Core: Infrastructure to facilitate research on post-traumatic Alzheimer’s disease and related dementias

by myneuronews September 9, 2025

by myneuronews September 9, 2025

Research Objectives The primary aim of the Boston University Alzheimer’s Disease Research Center Clinical Core …

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Traumatic brain injury
Progressive lifespan modifications in the corpus callosum following a single concussion in juvenile male mice monitored by diffusion MRI

by myneuronews September 9, 2025

by myneuronews September 9, 2025

Study Overview The investigation aimed to explore the long-term impacts of a single concussion on …

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Traumatic brain injury
A prolyl oligopeptidase ligand blocks memory deficit in a repeated mild traumatic brain injury model

by myneuronews September 8, 2025

by myneuronews September 8, 2025

Study Overview This research investigates the role of a prolyl oligopeptidase (POP) ligand in the …

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Artificial Intelligence in Traumatic Brain Injury: A Systematic Review of Prognostic, Diagnostic, and Monitoring Applications
Traumatic brain injury (TBI) remains a leading cause of death and disability worldwide, with outcomes that are highly heterogeneous and difficult to predict using conventional clinical tools. Artificial intelligence (AI) has emerged as a promising approach to enhance diagnosis, prognostication, and management of TBI across diverse care settings. Following PRISMA guidelines, a comprehensive search of […]
Transcranial direct current stimulation (tDCS) in conscious mice: a refined method for repetitive applications without restraint
Transcranial direct current stimulation (tDCS) for painless, non-invasive brain stimulation is a promising approach to enhance recovery after stroke. However, the precise molecular and cellular mechanisms underlying the effects of tDCS remain unclear, impeding its use in humans and necessitating research in experimental animals. Unlike humans, who receive tDCS fully awake, experimental models of tDCS […]
A study on the association of apolipoprotein E with oxidative stress markers, neurological function, and cognitive impairment following traumatic brain injury
CONCLUSION: ApoE exhibits an injury-severity-dependent increase during the early stage of TBI, and its levels are closely associated with oxidative stress imbalance and cognitive impairment. These findings suggest that ApoE may play a critical role in both the pathological progression and neural repair following TBI.
A comprehensive review on adaptive plasticity and recovery mechanisms post-acquired brain injury
Adaptive plasticity, the brain's ability to reorganize and form new neural connections after injury, is crucial for recovery following acquired brain injury (ABI). This process involves axonal sprouting, dendritic remodeling, and neurogenesis, which restore neural connections and compensate for lost functions. While neuroinflammation and reactive astrocytes aid tissue repair, optimizing these responses to minimize secondary […]
Sex differences in fixational eye movements following concussion
Recent research supports impairments in fixational eye movements (FEMs), small motions of the eye that occur during periods when gaze is maintained on a fixed target, as an objective biomarker of concussion. Preliminary work has demonstrated that fixational saccades are larger following a concussion; however, sex differences in FEMs and fixational saccades have not been […]