The wake-active serotonergic system (STS) has been considered part of the ascending arousal system that promotes wakefulness. Using zebrafish and mice, Oikonomou, Altermatt et al. demonstrate that the STS promotes sleep, potentially by generating homeostatic sleep pressure during wakefulness.

Zheng et al. defined distinct intrinsic physiological properties and transcriptome profiles of eight somatosensory neuron subtypes and further revealed subtype-specific contributions of differentially expressed potassium channels to the intrinsic membrane properties in these sensory neurons.

ABSTRACT

Objective

The aim of the study was to report 12‐month changes after treatment with Nusinersen in a cohort of 85 type I Spinal Muscular Atrophy patients of age ranging from 2 months to 15 years and 11 months.

Methods

All patients were assessed using the Children’s Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP INTEND) and the Hammersmith Infant Neurological Examination‐Section 2 (HINE‐2).… Read More...

Juvenile myoclonic epilepsy (JME) is characterized by the presence of bilateral myoclonic, generalized myoclonic, tonic–clonic, and (less often) absence seizures. Its prevalence comprises 5–10% of all epilepsies and 18% of genetic (idiopathic) generalized epilepsies [1]. Clinical symptoms occur between 6 and 22 years of age, most frequently during adolescence: age at onset is 13–16 years in half of affected patients [2].… Read More...

While mechanical thrombectomy (MT) has been shown to be effective in the treatment of acute large vessel occlusions, adjunctive measures, such as balloon guide catheters (BGC) and aspiration techniques, are utilized heterogeneously. Clarifying the effects of aspiration applied to the anterior cerebral circulation with proximal flow arrest can shed light on embolic protection during MT.… Read More...

Pulse wave velocity is commonly regarded as the most effective and noninvasive indicator for evaluating arterial stiffness, while increased arterial stiffness is known to be related to atherosclerosis, which has been proved to play a significant role on the onset of acute ischemic stroke.… Read More...

Intravascular lymphomatosis (IVL) is a rare subtype of large B-cell lymphoma that follows an aggressive course with rapidly progressive neurological involvement and potentially fatal outcome.1 We report on a 64-year-old man with progressive myelopathy at T6-T7 and recurrent cerebral infarctions. This case is illustrative of the clinical course that is seen in IVL.… Read More...

Aim: To examine the association of the amount of rehabilitation with functional gains of elderly stroke patients at a convalescent rehabilitation ward using propensity score analysis methods and the Japan Rehabilitation Database.Methods: This study was a retrospective cohort study. From the database, 6875 patients who were admitted to the convalescent rehabilitation wards with stroke were identified.… Read More...

Postoperative cerebral embolism after left upper or lower lobectomy caused by the thrombus in the pulmonary vein stump (PVS) is a rare complication. However, it is still unclear how the cerebral embolism develop after lobectomy, and how can we prevent further embolism after thrombus removal.… Read More...