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2D Virtual Reality-Based Exercise Improves Spatial Navigation in Institutionalized Non-robust Older…
Background: Spatial navigation is a prodromal dementia marker. Exercise used alongside virtual reality improves many cognitive functions, but effects on spatial navigation are still unclear.Objective: To investigate the effect of virtual…
The Effects of Bicycle Simulator Training on Anticipatory and Compensatory Postural Control in Older…
Background: Falls are the leading cause of fatal and non-fatal injuries among older adults. Perturbation-Based-Balance Training (PBBT) is a promising approach to reduce fall rates by improving reactive balance responses. PBBT programs are…
Pragmatic Profiles of Toddlers With Autism Spectrum Disorder at the Onset of Speech
Using speech to communicate pragmatic functions is challenging among individuals with Autism Spectrum Disorder (ASD). Given the role language plays in developing everyday skills, we traced the unique pragmatic profile of early words,…
Efficacy of an Interdisciplinary Intensive Outpatient Program in Treating Combat-Related Traumatic…
Background: Since 2000, over 413,000 US service members (SM) experienced at least one traumatic brain injury (TBI), and 40% of those with in-theater TBIs later screened positive for comorbid psychological health (PH) conditions, including…
Paclitaxel Coated Balloon vs. Bare Metal Stent for Endovascular Treatment of Symptomatic Vertebral…
Background: Stenting treatment for refractory symptomatic patients with vertebral artery origin stenosis (VAOS) is safe; however, there is a high rate of in-stent restenosis. Although drug-eluting stents can reduce the incidence of…
Unmet Needs of People With Parkinson’s Disease and Their Caregivers During COVID-19-Related…
Self-perceived unmet needs in people with typical and atypical parkinsonism (PwP) and their caregivers, support network, personalized ways to address self-perceived unmet needs during confinement, as well as the prevalence of self-reported…
Impaired Ganglion Cell Function Objectively Assessed by the Photopic Negative Response in Affected…
Purpose: The photopic negative response (PhNR) is an electrophysiological method that provides retinal ganglion cell function assessment using full-field stimulation that does not require clear optics or refractive correction. The purpose…
Neurophysiological Changes in the First Year After Cell Transplantation in Sub-acute Complete…
Neurophysiological testing can provide quantitative information about motor, sensory, and autonomic system connectivity following spinal cord injury (SCI). The clinical examination may be insufficiently sensitive and specific to reveal…
Striatal Dopamine Induced ERK Phosphorylation Is Altered in Mouse Models of Monogenic Dystonia
Chiara Melis,
Genevieve Beauvais,
Brian S. Muntean,
Maria‐Daniela Cirnaru,
Garrett Otrimski,
Jordi Creus‐Muncunill,
Kirill A. Martemyanov,
Pedro Gonzalez‐Alegre,
Michelle E. Ehrlich
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ABSTRACT
Background
Similar to some monogenic forms of dystonia, levodopa‐induced dyskinesia is a hyperkinetic movement disorder with abnormal nigrostriatal dopaminergic neurotransmission. Molecularly, it is characterized by…