Grigorios Oikonomou, Michael Altermatt, Rong-wei Zhang, Gerard M. Coughlin, Christin Montz, Viviana Gradinaru, David A. Prober June 24, 2019

The wake-active serotonergic system (STS) has been considered part of the ascending arousal system that promotes wakefulness. Using zebrafish and mice, Oikonomou, Altermatt et al. demonstrate that the STS promotes sleep, potentially by generating homeostatic sleep pressure during wakefulness.

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Yang Zheng, Pin Liu, Ling Bai, James S. Trimmer, Bruce P. Bean, David D. Ginty June 24, 2019

Zheng et al. defined distinct intrinsic physiological properties and transcriptome profiles of eight somatosensory neuron subtypes and further revealed subtype-specific contributions of differentially expressed potassium channels to the intrinsic membrane properties in these sensory neurons.

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Marika Pane, Giorgia Coratti, Valeria A Sansone, Sonia Messina, Claudio Bruno, Michela Catteruccia, Maria Sframeli, Emilio Albamonte, Marina Pedemonte, Adele D'Amico, Chiara Bravetti, Beatrice Berti, Giorgia Brigati, Paola Tacchetti, Francesca Salmin, Roberto Sanctis, Simona Lucibello, Marco Piastra, Orazio Genovese, Enrico Bertini, Giuseppe Vita, Francesco Danilo Tiziano, Eugenio Mercuri, on behalf of the Italian EAP working group, Daniela Lauro, Luca Binetti, Anita Pallara, Simona Spinoglio, Maria Letizia Solinas, Grazia Zappa, Francesca Penno, Cristina Ponzanelli, Jacopo Casiraghi, Irene Bruno, Federica Ricci, Giovanni Baranello, Daniela Leone, Gloria Ferrantini, Concetta Palermo, Maria Carmela Pera, Nicola Forcina, Sara Carnicella, Giulia Norcia, Lavinia Fanelli, Alessandro Pedicelli, Annalia Frongia, Antonio Versaci, Imma Rulli, Eloisa Gitto, Cristina Faraone, Vincenzo Di Bella, Stefania La Foresta, Maria Macrì, Giulia Colia, Anna Maria Bonetti, Adelina Carlesi, Renato Cutrera, Maria Beatrice Chiarini, Marta Ferretti, Alberto Garaventa, Giovanni Montobbio, Carlo Gandolfo, Valentina Iurilli, Paola Tacchetti, Emilia Bobeica, Valentina Lanzillotta, Alice Pirola, Sara Lupone, Elisa De Mattia, Elisa Falcier, Fabrizio Rao, Elisabetta Roma, Caterina Conti, Cristina Grandi, Fausto Fedeli, Luca Mancini, Nicola Tovaglieri, Paolo Stoia, Maurizio Heinen, Valeria Cozzi, Beatrice Travaglia, Emma Mizzotti June 23, 2019

ABSTRACT

Objective

The aim of the study was to report 12‐month changes after treatment with Nusinersen in a cohort of 85 type I Spinal Muscular Atrophy patients of age ranging from 2 months to 15 years and 11 months.

Methods

All patients were assessed using the Children’s Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP INTEND) and the Hammersmith Infant Neurological Examination‐Section 2 (HINE‐2).… Read More...

Reyhan Gürer, Şenay Aydın, Çiğdem Özkara June 22, 2019

Juvenile myoclonic epilepsy (JME) is characterized by the presence of bilateral myoclonic, generalized myoclonic, tonic–clonic, and (less often) absence seizures. Its prevalence comprises 5–10% of all epilepsies and 18% of genetic (idiopathic) generalized epilepsies [1]. Clinical symptoms occur between 6 and 22 years of age, most frequently during adolescence: age at onset is 13–16 years in half of affected patients [2].… Read More...

Hideo Okada, Yoshikazu Matsuda, Alex Malisch, Joonho Chung, Daniel M. Heiferman, Demetrius K. Lopes June 22, 2019

While mechanical thrombectomy (MT) has been shown to be effective in the treatment of acute large vessel occlusions, adjunctive measures, such as balloon guide catheters (BGC) and aspiration techniques, are utilized heterogeneously. Clarifying the effects of aspiration applied to the anterior cerebral circulation with proximal flow arrest can shed light on embolic protection during MT.… Read More...

Xianfan Zeng, Xian Fu, Xuelong Li, Jie Zhou, Shiyan Huang, Xianliang Li, Li Liao, Qingchun Gao June 22, 2019

Pulse wave velocity is commonly regarded as the most effective and noninvasive indicator for evaluating arterial stiffness, while increased arterial stiffness is known to be related to atherosclerosis, which has been proved to play a significant role on the onset of acute ischemic stroke.… Read More...

Stephanie Lyden, Rima M. Dafer June 22, 2019

Intravascular lymphomatosis (IVL) is a rare subtype of large B-cell lymphoma that follows an aggressive course with rapidly progressive neurological involvement and potentially fatal outcome.1 We report on a 64-year-old man with progressive myelopathy at T6-T7 and recurrent cerebral infarctions. This case is illustrative of the clinical course that is seen in IVL.… Read More...

Tomohiko Kamo, Ryo Momosaki, Keisuke Suzuki, Ryoma Asahi, Masato Azami, Hirofumi Ogihara, Yuusuke Nishida June 22, 2019

Aim: To examine the association of the amount of rehabilitation with functional gains of elderly stroke patients at a convalescent rehabilitation ward using propensity score analysis methods and the Japan Rehabilitation Database.Methods: This study was a retrospective cohort study. From the database, 6875 patients who were admitted to the convalescent rehabilitation wards with stroke were identified.… Read More...

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