Altered microstate dynamics in Functional Neurological Disorder

February 26, 2026

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Functional connectivity predictors and mechanisms of symptom change in functional neurological disorder
Study Overview The research investigates the relationship between functional connectivity patterns in the brain and the changes in symptoms experienced by individuals diagnosed with functional neurological disorder (FND). FND encompasses a range of neurological symptoms that cannot be attributed to any identifiable neurological or medical condition, often resulting from a complex interaction of psychological and… Read more: Functional connectivity predictors and mechanisms of symptom change in functional neurological disorder
Seismocardiographic Evidence of Deteriorating Cardiac Function Among Canadian Police Officers: Evidence from the Longitudinal Royal Canadian Mounted Police Posttraumatic Stress Disorder Study
Study Overview The investigation focuses on the cardiac health of Canadian police officers, specifically examining how posttraumatic stress disorder (PTSD) impacts cardiac function over time. Utilizing the Royal Canadian Mounted Police (RCMP) as a case study, the research employs seismocardiography—an innovative technique that measures vibrations generated by heartbeats—to assess changes in cardiac function longitudinally in… Read more: Seismocardiographic Evidence of Deteriorating Cardiac Function Among Canadian Police Officers: Evidence from the Longitudinal Royal Canadian Mounted Police Posttraumatic Stress Disorder Study
Functional connectivity predictors and mechanisms of symptom change in functional neurological disorder
Study Overview This research investigates the mechanisms behind symptom changes in individuals diagnosed with functional neurological disorder (FND), focusing on the role of functional connectivity as a predictive factor. FND, characterized by neurological symptoms without a clear organic cause, presents challenges in both diagnosis and treatment. The study aims to better understand how variations in… Read more: Functional connectivity predictors and mechanisms of symptom change in functional neurological disorder
Association of therapeutic plasma exchange with functional outcomes in selected neurological disorders: a retrospective cohort study from a single tertiary center in Saudi Arabia
Study Overview This retrospective cohort study aimed to evaluate the effectiveness of therapeutic plasma exchange (TPE) in improving functional outcomes for patients diagnosed with specific neurological disorders at a tertiary care center in Saudi Arabia. The study focused on individuals undergoing TPE, assessing its impact on their clinical conditions over a defined period. Selection criteria… Read more: Association of therapeutic plasma exchange with functional outcomes in selected neurological disorders: a retrospective cohort study from a single tertiary center in Saudi Arabia
Discovery of a novel idebenone-rhein hybrid 4c with enhanced NQO1 expression for neuroprotection against cerebral ischemia-reperfusion injury
Study Overview The research focuses on the development and evaluation of a new hybrid compound, idebenone-rhein hybrid 4c, which has shown potential in enhancing the expression of NAD(P)H:quinone oxidoreductase 1 (NQO1). This enzyme plays a crucial role in cellular defense against oxidative stress, particularly under conditions of ischemic injury, where blood flow is restricted to… Read more: Discovery of a novel idebenone-rhein hybrid 4c with enhanced NQO1 expression for neuroprotection against cerebral ischemia-reperfusion injury

Relief and Prevention of Post-Traumatic Headache Using Intranasal Delivery of Lidocaine for Youth (RAPPIDLY): A Feasibility Study
Post-traumatic headache (PTH) is prevalent following concussion, yet few evidence-based treatments exist. Intranasal lidocaine (INL) may help treat migraine; however, it has not been studied specifically for PTH in youth populations. The objectives are to describe the feasibility and acceptability of INL as a PTH treatment for youth in a concussion clinic, explore the change […]
Sport-Related Concussion Prevention Programs in Soccer: A Scoping Review Using the RE-AIM Framework
CONCLUSIONS: Concussion programs in soccer seem to produce short-term benefits but remain inadequately evaluated in adoption, implementation, fidelity, and sustainability. Future research should prioritize longitudinal designs and comprehensive RE-AIM reporting to support scalable and sustainable concussion program implementation strategies.
The Response of the Default Mode Network to Aerobic Exercise in Pediatric Concussion
Submaximal aerobic exercise is an evidence-informed strategy for concussion management. However, its impact on the concussed pediatric brain remains poorly understood. A seminal adult study reported stability of default mode network (DMN) functional connectivity before and immediately after aerobic exercise in adults with mild traumatic brain injury. Comparable data do not exist in children, despite […]
Concussion-Type Symptoms After Head Trauma in a Patient With No Apparent Neck Signs or Symptoms: A Case Report of Cervicogenic Concussion and Response to Targeted Cervical Adjustments/Manipulation
In two head trauma events occurring 38 years apart, the same male patient presented to the same chiropractor with concussion-type symptoms, including headaches, dizziness, visual disturbances, and cognitive slowness (brain fog), but no neck pain and normal standard orthopedic neck test results. The chiropractor initially diagnosed the patient with concussion/mild traumatic brain injury (mTBI). A […]
Head Impact Exposure Across Levels of Play in American Football: A Systematic Review of Accelerometer Data
With growing concern about the long-term effects of head injuries in contact sports, understanding differences in head impact exposure (HIE) across age groups is critical. Youth athletes may face heightened risks due to developmental vulnerability, yet the relationship between level of play and HIE remains unclear. This systematic review compares HIE characteristics between youth (≤14 […]

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