Evidence for a diagnostic distinction between functional seizures and functional motor symptoms from the TriNetX electronic health record database

February 26, 2026

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Long-Term Opioid Therapy Tapering and Risk of Substance Use Disorder and Overdose: Differences by Opioid Dose and Duration
Study Overview The research focuses on the complex relationship between tapering long-term opioid therapy and the associated risks of developing substance use disorders and experiencing overdose incidents. This issue has gained heightened attention due to the ongoing opioid crisis, which has prompted a re-evaluation of how chronic pain management is approached, particularly concerning opioid prescribing… Read more: Long-Term Opioid Therapy Tapering and Risk of Substance Use Disorder and Overdose: Differences by Opioid Dose and Duration
Association of the triglyceride-glucose index with the severity and short-term prognosis of Guillain-Barré syndrome
Study Overview This research investigates the relationship between the triglyceride-glucose (TyG) index and the severity as well as the short-term outcomes in individuals diagnosed with Guillain-Barré Syndrome (GBS), an acute neurological disorder characterized by rapid onset muscle weakness. The TyG index, a composite measure derived from triglyceride and glucose levels, has emerged as a potential… Read more: Association of the triglyceride-glucose index with the severity and short-term prognosis of Guillain-Barré syndrome
The Electrophysiology of Disease Remission in Chronic Inflammatory Demyelinating Polyneuropathy
Electrophysiological Changes in Disease Remission During periods of remission in patients with Chronic Inflammatory Demyelinating Polyneuropathy (CIDP), significant electrophysiological alterations can be observed that reflect the underlying physiological changes associated with the disease. One of the hallmark findings in remission is the improvement of nerve conduction velocities (NCVs), which are often markedly decreased during active… Read more: The Electrophysiology of Disease Remission in Chronic Inflammatory Demyelinating Polyneuropathy
Microglial ferroptosis mediated neuroinflammation in central nervous system diseases
Study Overview The exploration of microglial ferroptosis and its contribution to neuroinflammation in central nervous system (CNS) diseases has emerged as a significant area of research in neurology and immunology. This study delves into the intricate relationship between microglial cell death via ferroptosis—a form of regulated cell death characterized by iron-dependent lipid peroxidation—and the inflammatory… Read more: Microglial ferroptosis mediated neuroinflammation in central nervous system diseases
Individually timed upper-limb post-activation performance enhancement improves 50 m front crawl performance in national-level swimmers
Study Overview The research investigated the impact of individually timed upper-limb post-activation performance enhancement (PAPE) on the 50-meter front crawl swimming performance among national-level swimmers. This phenomenon, PAPE, relates to an improvement in muscle performance that follows a high-intensity exercise session, which is hypothesized to stimulate the body’s neuromuscular system. In this context, understanding whether… Read more: Individually timed upper-limb post-activation performance enhancement improves 50 m front crawl performance in national-level swimmers

Traumatic Encephalopathy Syndrome in the Late Effects of Traumatic Brain Injury (LETBI) Study Cohort
BACKGROUND AND OBJECTIVE: Traumatic encephalopathy syndrome (TES) is the proposed clinical manifestation of chronic traumatic encephalopathy (CTE) neuropathologic change secondary to repetitive head impacts (RHI). The prevalence of TES and its component symptoms is not known in individuals with single TBI, a subset of whom also have RHI. We used prospectively collected data to operationalize […]
Benign Paroxysmal Positional Vertigo in Patients with Mild Traumatic Brain Injury: A Multidisciplinary Study
CONCLUSION: The incidence of t-BPPV in a Dutch population that presents at the ED with mild TBI was 12.8%. Female sex and undergoing high-energy trauma were shown to be risk factors for the occurrence of t-BPPV.
Comparison of strategies for the use of brain injury biomarkers in mild traumatic brain injury
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Correlation Between Accommodative Facility and Light-Evoked Pupil Responses in Individuals with History of Mild Traumatic Brain Injury
CONCLUSIONS: The results of this small-sample study suggest that accommodative function and light-evoked pupillary dynamics are correlated in individuals with a history of TBI. Those with accommodative dysfunction showed greater pupil constriction amplitudes and velocities and this relationship may reflect shared autonomic or oculomotor mechanisms.
A Decision Tree Cost Analysis of Intracranial Bleed Detection Using a Near-Infrared Device Across Various Healthcare Levels
Traumatic brain injury (TBI), mainly caused by road traffic accidents, is a serious global public health concern. Computed tomography (CT) is the best way to detect intracranial haemorrhage (ICH), but it is not always feasible because it is hard to access, exposes people to radiation, and is expensive, especially in low- and middle-income countries. Portable […]

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