Evidence for a diagnostic distinction between functional seizures and functional motor symptoms from the TriNetX electronic health record database

February 26, 2026

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Targeting glycine transporter type 1 (GlyT1) in epilepsy: Pathophysiological rationale and therapeutic perspectives
Pathophysiological Basis of GlyT1 in Epilepsy The role of glycine transporters, particularly Glycine Transporter Type 1 (GlyT1), has become an important area of research in understanding epilepsy. GlyT1 is a key player in regulating glycine levels in the central nervous system, which powers several critical neurological processes. The balance of excitatory and inhibitory neurotransmitters is… Read more: Targeting glycine transporter type 1 (GlyT1) in epilepsy: Pathophysiological rationale and therapeutic perspectives
289th ENMC international workshop: assessing and managing emerging AAV related toxicities after gene therapy for neuromuscular disorders, 26 – 28 September 2025, Hoofddorp, The Netherlands
Background and Context The advent of adeno-associated virus (AAV) vectors has marked a significant milestone in the domain of gene therapy, particularly for neuromuscular disorders. AAV vectors are known for their ability to deliver therapeutic genes with a relatively high safety profile. These features have fueled their application in treating conditions such as spinal muscular… Read more: 289th ENMC international workshop: assessing and managing emerging AAV related toxicities after gene therapy for neuromuscular disorders, 26 – 28 September 2025, Hoofddorp, The Netherlands
Adjunct Medications for Single-Injection Pediatric Regional Blocks: Implications for Peripheral Nerve Blocks
Adjunct Medication Strategies In the realm of pediatric regional anesthesia, the use of adjunct medications alongside single-injection nerve blocks has emerged as a focal area of research. These adjuncts aim to enhance the efficacy of the primary anesthetic through various mechanisms, ultimately leading to better pain management in children undergoing surgical procedures. Several classes of… Read more: Adjunct Medications for Single-Injection Pediatric Regional Blocks: Implications for Peripheral Nerve Blocks
The impact of frailty and its changes on the development of motoric cognitive risk syndrome in middle-aged and older adults
Understanding Frailty and Motoric Cognitive Risk Frailty is a clinical syndrome characterized by a decrease in physiological reserves and increased vulnerability to stressors. This decline often manifests in reduced strength, endurance, and overall physiological function. It typically affects older adults, although risk factors such as lifestyle, chronic diseases, and even genetics can influence its onset… Read more: The impact of frailty and its changes on the development of motoric cognitive risk syndrome in middle-aged and older adults
Resting-State Brain Entropy Reveals Altered Neural Dynamics and Cognitive Associations in Mild Traumatic Brain Injury: A Longitudinal Study
Study Overview This longitudinal study investigated the complexities of neural dynamics in individuals suffering from mild traumatic brain injury (mTBI). The research was aimed at understanding how resting-state brain entropy, a measure of the randomness and complexity of brain activity during rest, can provide insights into cognitive functioning and recovery following mTBI. Participants included individuals… Read more: Resting-State Brain Entropy Reveals Altered Neural Dynamics and Cognitive Associations in Mild Traumatic Brain Injury: A Longitudinal Study

Resting-State Brain Entropy Reveals Altered Neural Dynamics and Cognitive Associations in Mild Traumatic Brain Injury: A Longitudinal Study
Mild traumatic brain injury (mTBI) is associated with persistent physical, cognitive, and emotional symptoms, yet the functional brain changes that accompany recovery remain incompletely understood. This longitudinal study investigated brain entropy (BEN), a resting-state measure of irregularity or complexity of spontaneous BOLD activity derived from resting-state functional magnetic resonance imaging (rs-fMRI), during the first year […]
eHealth literacy mediates the relationship between health literacy and concussion attitudes among parents in South Korea
CONCLUSION: Higher HL was associated with more favorable concussion-related attitudes, but not with concussion-related knowledge. An indirect association between HL and concussion-related attitudes was observed through e-HL, but not through concussion-related knowledge. This indirect association was consistent with the hypothesized model but did not establish temporal precedence or causal mediation. These findings suggest that future […]
Characteristics of head injuries in children at King Abdullah Specialized Children's Hospital, Jeddah: a cross-sectional study
INTRODUCTION: Head injuries in children are a leading cause of death and long-term disability worldwide. However, detailed data on the characteristics of pediatric head injuries across different regions of Saudi Arabia remain limited. In this study, conducted at King Abdullah Specialized Children's Hospital (KASCH) in Jeddah, we aimed to identify the distinctive patterns of head […]
Exploratory proteomic biomarker combinations associated with post-concussion symptoms following a concussion in adolescents
CONCLUSION: This study suggests the possibility to utilize novel biomarkers discovered by high throughput proteomic analysis to predict high PPCS. Future research should further develop precision of unique biomarker profiles and prolonged symptomatology in adolescents' post-concussion.
Reframing the "mild" in mild traumatic brain injury: A comprehensive narrative review of diagnosis and treatment paradigms
Mild traumatic brain injury (mTBI) constitutes a pervasive yet often overlooked public health challenge with far-reaching implications for individual well-being and healthcare systems globally. This review synthesizes contemporary evidence on diagnosis, management, and emerging treatment paradigms for mTBI using a structured, comprehensive literature search strategy. Through comprehensive literature analysis spanning multiple databases-PubMed, Cochrane Library, EMBASE, […]

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