Browsing Tag

parkinsonism

Synaptic Loss in Primary Tauopathies Revealed by [11C]UCB‐J Positron Emission Tomography

Abstract Background Synaptic loss is a prominent and early feature of many neurodegenerative diseases. Objectives We tested the hypothesis that synaptic density is reduced in the primary tauopathies of progressive supranuclear palsy…

Elevated In Vitro Kinase Activity in Peripheral Blood Mononuclear Cells of Leucine‐Rich Repeat…

Abstract Background Leucine‐rich repeat kinase 2 kinase inhibitors are being vigorously pursued as potential therapeutic options; however, there is a critical need for sensitive and quantitative assays of leucine‐rich repeat kinase 2…

CD4+ T‐Cell Transcription Factors in Idiopathic REM Sleep Behavior Disorder and Parkinson’s Disease

Abstract Background CD4+ T‐cell dysregulation occurs in Parkinson’s disease (PD); however, it is unknown whether it contributes to PD development. The objective of this study was to investigate transcription factor gene expression in CD4+…

Dietary Antioxidants and Risk of Parkinson’s Disease in the Singapore Chinese Health Study

Abstract Background Despite experimental evidence implicating oxidative stress in the pathogenesis of PD, epidemiological studies have provided inconsistent associations between dietary antioxidants and risk of developing PD. Furthermore,…

Safety of Plasma Infusions in Parkinson’s Disease

Abstract Background Young plasma infusions have emerged as a potential treatment for neurodegenerative disease, and convalescent plasma therapy has been used safely in the management of viral pandemics. However, the effect of plasma…

A Gain‐of‐Function Mutation in KCNMA1 Causes Dystonia Spells Controlled With Stimulant Therapy

Abstract Background The mutations of KCNMA1 BK‐type K+ channel have been identified in patients with various movement disorders. The underlying pathophysiology and corresponding therapeutics are lacking. Objectives To report our…

In Vivo Molecular Signatures of Cerebellar Pathology in Spinocerebellar Ataxia Type 3

Abstract Background No treatment exists for the most common dominantly inherited ataxia Machado‐Joseph disease, or spinocerebellar ataxia type 3 (SCA3). Successful evaluation of candidate therapeutics will be facilitated by validated…