Category:

Neuroinflammatory conditions

Neuroinflammatory conditions
Subcutaneous Botulinum Toxin Type-A Injections for the Treatment of Central Neuropathic Pain in a Patient With Multiple Sclerosis – A Case Report

by myneuronews June 27, 2025

by myneuronews June 27, 2025

Study Overview This case report examines the application of subcutaneous injections of botulinum toxin type …

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Neuroinflammatory conditions
SAMe and DADS attenuated cuprizone-induced demyelination via modulating H(2)S/AMPK/SIRT1/ULK1/beclin1 signaling

by myneuronews June 26, 2025

by myneuronews June 26, 2025

Study Overview This study investigates the effects of SAMe (S-adenosylmethionine) and DADS (diallyl disulfide) on …

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Neuroinflammatory conditions
Quaking Protein in Myelin Maintenance and Regeneration in the Central Nervous System

by myneuronews June 24, 2025

by myneuronews June 24, 2025

Quaking Protein Function in Myelin The quaking protein, also known as QKI, plays a critical …

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Neuroinflammatory conditions
Stiff tongue syndrome and multifocal immune neuropathy in a young man with anti-glutamic acid decarboxylase and unclassified antibodies

by myneuronews June 22, 2025

by myneuronews June 22, 2025

Study Overview This study investigates the clinical manifestations and underlying pathophysiological mechanisms of stiff tongue …

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Neuroinflammatory conditions
Generation of decellularized human brain tissue for investigating cell-matrix interactions: a proof-of-concept study

by myneuronews June 20, 2025

by myneuronews June 20, 2025

Study Overview This study explores the generation of decellularized human brain tissue, which serves as …

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Neuroinflammatory conditions
Case Report: Unilateral relapsing primary central nervous system vasculitis-expanding the phenotype

by myneuronews June 18, 2025

by myneuronews June 18, 2025

Study Overview This study focuses on a specific form of vasculitis affecting the central nervous …

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Neuroinflammatory conditions
Clinical profile of patients with comorbid IBD and MS, and associated service impact in England’s secondary care setting: a retrospective cohort study

by myneuronews June 18, 2025

by myneuronews June 18, 2025

Study Overview The study investigates the clinical characteristics of patients who are diagnosed with both …

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Neuroinflammatory conditions
Effectiveness of disease-modifying agents in ameliorating multiple sclerosis – A cross-sectional observational study

by myneuronews June 13, 2025

by myneuronews June 13, 2025

Study Overview This research was designed to assess the efficacy of disease-modifying agents (DMAs) in …

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Neuroinflammatory conditions
Effectiveness of disease-modifying agents in ameliorating multiple sclerosis – A cross-sectional observational study

by myneuronews June 13, 2025

by myneuronews June 13, 2025

Study Overview This study investigates the effectiveness of various disease-modifying agents (DMAs) in improving the …

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Neuroinflammatory conditions
Pentose phosphate pathway inhibition metabolically reprograms CD8+ T cells and disrupts CNS autoimmunity

by myneuronews June 10, 2025

by myneuronews June 10, 2025

Impact of Pentose Phosphate Pathway Inhibition The pentose phosphate pathway (PPP) serves a crucial role …

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Subcutaneous Botulinum Toxin Type-A Injections for the Treatment of Central Neuropathic Pain in a Patient With Multiple Sclerosis – A Case Report
Study Overview This case report examines the application of subcutaneous injections of botulinum toxin type…
Homozygous COQ9 mutation: a new cause of potentially treatable hereditary spastic paraplegia
Study Overview The research investigates the role of homozygous mutations in the COQ9 gene as…
Trends in acute care of cerebrovascular events- a joinpoint analysis with German hospital data from 2000 to 2021
Cerebrovascular Event Trends The prevalence and incidence of cerebrovascular events, commonly known as strokes, have…
Gepants in Primary Care: A Targeted Approach to Acute and Preventive Treatment of Migraine
Gepants Mechanism of Action Gepants are a novel class of oral medications specifically designed to…
Targeting cognitive aging with curcumin supplementation: A systematic review and meta-analysis
Study Overview The systematic review and meta-analysis centered on curcumin supplementation aimed to investigate its…

Adaptive trial for the treatment of depressive symptoms associated with concussion using accelerated intermittent theta burst stimulation (ADEPT): rationale, design and methods
Military service members (SMs) and veterans who have sustained one or more concussions during their service have significantly higher rates of persistent depressive symptoms and suicidality compared to non-injured peers. Despite over 500,000 SMs who have sustained concussions, there are currently no Level I evidence-based treatments for improving depressive symptoms associated with concussion. Accelerated intermittent […]
Dietary Intake of n-3 Polyunsaturated Fatty Acids Prior to a Mild Traumatic Brain Injury Demonstrates a Dose-Response Effect for Neuroprotective Benefits in Male C57BL/6 Mice
CONCLUSIONS: Overall, these results show that dietary n-3 PUFA confer neuroprotective benefits in mice resulting in significantly improved functional outcomes. This work is relevant to clinical practitioners, athletes, and the general population who aim to support their neurological health through dietary or supplementary n-3 PUFA.
Differential DNA Methylation of the Brain-Derived Neurotrophic Factor Gene is Observed after Pediatric Traumatic Brain Injury Compared to Orthopedic Injury
CONCLUSIONS AND RELEVANCE: BDNF DNAm appears to differ in children with TBI vs OI, particularly in the acute period. BDNF DNAm differences may reflect early biological responses that are specific to TBI.
Multimodal Magnetic Resonance Imaging with Mild Repetitive Head Injury in Awake Rats: Modeling the Human Experience and Clinical Condition
Mild repetitive head injury is a serious health problem with long-term negative consequences. Changes in brain neurobiology were assessed with MRI in a model of head injury designed to reflect the human experience. Rats were maintained on a reverse light-dark cycle and head impacted daily at 24 h intervals over three days while fully awake […]
Microstructural Damage Progression in the Pia-Arachnoid Complex
Traumatic brain injury is a leading cause of death and disability worldwide, with mild traumatic brain injury comprising the majority of cases. The pia-arachnoid complex (PAC), located at the brain-skull interface, plays a critical role in brain mechanics during head impacts, yet its response to mechanical loading is understudied. This study investigates the progression of […]