Jeroen Hoogland, Judith A. Boel, Rob M.A. Bie, Ben A. Schmand, Ronald B. Geskus, John C. Dalrymple‐Alford, Connie Marras, Charles H. Adler, Daniel Weintraub, Carmen Junque, Kenn F. Pedersen, Brit Mollenhauer, Jennifer G. Goldman, Alexander I. Tröster, David J. Burn, Irene Litvan, Gert J. Geurtsen, on behalf of the MDS Study Group “Validation of Mild Cognitive Impairment in Parkinson Disease” January 17, 2019

Abstract

Background

The International Parkinson and Movement Disorders Society criteria for mild cognitive impairment in PD need validation. The objectives of this present study were to evaluate prognostic validity of level I (abbreviated) International Parkinson and Movement Disorders Society mild cognitive impairment in PD criteria for development of PD dementia and compared them with level II (comprehensive) criteria.… Read More...

David P. Breen, Glenda M. Halliday, Anthony E. Lang January 17, 2019

ABSTRACT

Spread of α‐synuclein pathology from the peripheral to central nervous system may be an important etiological factor in Parkinson’s disease, although there are some unanswered questions about its correlation with neuronal loss. Experimental evidence has highlighted the gastrointestinal tract as a potential starting point for aggregated α‐synuclein, with the vagus nerve acting as a “highway” by which pathology may be transmitted to the lower brain stem.… Read More...

Klaus Seppi, K. Ray Chaudhuri, Miguel Coelho, Susan H. Fox, Regina Katzenschlager, Santiago Perez Lloret, Daniel Weintraub, Cristina Sampaio, and the collaborators of the Parkinson's Disease Update on Non‐Motor Symptoms Study Group on behalf of the Movement Disorders Society Evidence‐Based Medicine Committee January 17, 2019

ABSTRACT

Objective

To update evidence‐based medicine recommendations for treating nonmotor symptoms in Parkinson’s disease (PD).

Background

The International Parkinson and Movement Disorder Society Evidence‐Based Medicine Committee’s recommendations for treatments of PD were first published in 2002, updated in 2011, and now updated again through December 31, 2016.… Read More...

Juan Antonio Moreno-Bravo, Sergi Roig Puiggros, Patrick Mehlen, Alain Chédotal January 17, 2019

Moreno-Bravo et al. use a conditional-knockout strategy and light sheet fluorescence microscopy to show that netrin-1 from ventricular zone progenitors and netrin-1 from the floor plate cooperate to guide spinal cord commissural axons to and across the midline.

Read More...Read More...
Zhuhao Wu, Shirin Makihara, Patricia T. Yam, Shaun Teo, Nicolas Renier, Nursen Balekoglu, Juan Antonio Moreno-Bravo, Olav Olsen, Alain Chédotal, Frédéric Charron, Marc Tessier-Lavigne January 17, 2019

Recent studies have queried the role of netrin1 from floor plate (FP-netrin1) in guiding commissural axons. Wu et al. show that, in spinal cord, FP-netrin1 is required and acts at long range to guide commissural axons, collaborating with Shh.

Read More...Read More...
Carmen Fourier, Caroline Ran, Anna Steinberg, Christina Sjöstrand, Elisabet Waldenlind, Andrea Carmine Belin January 17, 2019

Objective

The purpose of this study was to investigate the HCRTR2 gene variants rs3122156, rs2653342, and rs2653349 in a large homogenous Swedish case‐control cohort in order to further evaluate the possible contribution of HCRTR2 to cluster headache.

Background

Cluster headache is a severe neurovascular disorder and the pathophysiology is not yet fully understood.… Read More...

Andoird App
Loading...