Dissociative seizures—also referred to as psychogenic non-epileptic seizures— account for about 20% of referrals to seizure clinics [1]. Traditionally, neurologists have viewed their role as limited to the diagnosis of dissociative seizures rather than the treatment of this disorder [2]. While there is currently no clear evidence base, expert opinion has favoured psychotherapeutic treatments [3], although most patients perceive their dissociative seizures as a problem which is largely “physical” [4].… Read More...

Focal (partial onset) seizures are often treated similarly in children over 4 years of age and in adolescent or adult patients [1,2]. As in adults, over 25% of children have inadequate seizure control on currently available antiepileptic drugs (AEDs), or have experienced significant adverse drug effects [3,4].… Read More...

Background: Obstructive sleep apnea (OSA) is a probable risk factor with speculative roles in the induction or aggravation of acute ischemic stroke (AIS). Methods: The association between OSA and AIS severity was retrospectively analyzed using clinical data of first-onset AIS patients, admitted to our hospital between January 2013 and September 2016.… Read More...

Polycythemia vera is a chronic myeloproliferative neoplasm, which is primarily characterized by elevated erythrocyte count with the risk of thrombosis, hemorrhage, and vasomotor symptoms. More common reported about bleeding events are gastrointestinal, mucosal, and cutaneous bleeding. Spontaneous cerebral hemorrhage/bleeding is seldom reported.… Read More...

Microglia affect Alzheimer’s disease (AD) pathogenesis in opposing manners, by protecting against amyloid accumulation in early phases of the disease and promoting neuropathology in advanced stages. Recent res…

Targeted whole-exome sequencing (WES) is a powerful diagnostic tool for a broad spectrum of heterogeneous neurological disorders. Here, we aim to examine the impact on diagnosis, treatment and cost with early use of targeted WES in early-onset epilepsy.

WES was assessed for 180 patients with early-onset epilepsy (≤ 5 years) of unknown cause.… Read More...

Background: Transcranial magnetic stimulation (TMS) is widely used to probe corticospinal excitability through Motor Evoked Potential (MEP) amplitude measurements. The input-output (I/O) curve is a sigmoid-shaped relation between the MEP amplitude at incremented TMS intensities. The aim of this study was to examine the relationships between seven parameters derived from the sigmoid function.… Read More...

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron degenerative disease in adults and has also been proven to be a type of conformational disease associated with protein misfolding and dysfunction. To date, more than 150 distinct genes have been found to be associated with ALS, among which Superoxide Dismutase 1 (SOD1) is the first and the most extensively studied gene.… Read More...

Deep brain stimulation (DBS) has become the treatment of choice for advanced stages of Parkinson’s disease, medically intractable essential tremor, and complicated segmental and generalized dystonia. In addition to accurate electrode placement in the target area, effective programming of DBS devices is considered the most important factor for the individual outcome after DBS.… Read More...