Stephen B. Shrewsbury, Maria Jeleva, Kelsey H. Satterly, Jason Lickliter, John Hoekman January 19, 2019

Objective

Investigate the safety and pharmacokinetics (PK) of INP104, intranasal dihydroergotamine mesylate (DHE) administered via a Precision Olfactory Delivery (POD®) device, (Impel NeuroPharma, Seattle, WA) vs intravenous (IV) DHE and DHE nasal spray (Migranal®) in healthy adult subjects.… Read More...

Mario F.P. Peres, Arão Belitardo Oliveira, Juliane P. Mercante, Helder H. Kamei, Patricia R. Tobo, Todd D. Rozen, Morris Levin, Dawn C. Buse, Giancarlo Lucchetti January 19, 2019

Background

Optimism and pessimism are related to several mental health and brain disorders, are significant predictors of physical and psychological health outcomes, and implicated as psychosocial determinants of the pain experience. Despite this promising evidence, limited information is available on optimism and pessimism in headache disorders.… Read More...

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