Aldo Quattrone, Maurizio Morelli, Basilio Vescio, Salvatore Nigro, Emilio Le Piane, Umberto Sabatini, Manuela Caracciolo, Virginia Vescio, Andrea Quattrone, Gaetano Barbagallo, Carlo Stanà, Giuseppe Nicoletti, Gennarina Arabia, Rita Nisticò, Fabiana Novellino, Maria Salsone February 14, 2019

ABSTRACT

Background

No prospective study of patients with Parkinson’s disease (PD) has investigated the appearance of vertical gaze abnormalities, a feature suggestive of progressive supranuclear palsy (PSP).

Objective

To identify, within a cohort of patients with an initial diagnosis of PD, those who developed vertical gaze abnormalities during a 4‐year follow‐up, and to investigate the performance of new imaging biomarkers in predicting vertical gaze abnormalities.… Read More...

Karolina Skagen, Siri Opsahl Hetlevik, Mahtab Zamani, Vibke Lilleby, Mona Skjelland February 14, 2019

This study investigated preclinical atherosclerosis in patients with juvenile mixed connective tissue disease (JMCTD), which is a chronic inflammatory disease with a varied phenotype. Mixed connective tissue disease (MCTD) has well known associations with other autoimmune diseases known to have increased risk of cardiovascular disease.… Read More...

Christopher T. Primiani, Angel Chinea Vicente, Michael T. Brannick, Aquilla S. Turk, J Mocco, Elad I. Levy, Adnan H. Siddiqui, Maxim Mokin February 14, 2019

Background: The two most common approaches to thrombectomy of emergent large vessel occlusion (direct aspiration and primary stent retriever thrombectomy) have been extensively studied; however, the detailed benefit and risk comparison is largely unknown. Objective: To conduct a systematic review and meta-analysis to compare radiographic and clinical outcomes between the use of primary stent retrievers and direct aspiration in management of acute ischemic stroke.… Read More...

Morteza Gholami, Mahsa Mohammad Amoli February 14, 2019

Wang et al1 recently published a meta-analysis on the role of miR-146a polymorphism (rs11614913 T C) and susceptibility to ischemic stroke and coronary artery disease (CAD) in Asian population and concluded that the recalled variant “may contribute to CAD susceptibility.” They showed the result related to the protective effect of CAD in homozygote model (CC versus TT, OR = .43, 95%CI = .39-.47, P < .00001), as their most significant result, and indicated that “carrying CC homozygote genotype may play a protective role in development of disease.” While other results of their meta-analysis increased the risk of disease or had no significant effect (Fig 3 in Wang1 meta-analysis).

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Yuya Kato, Miki Fujimura, Kenichi Sato, Hidenori Endo, Teiji Tominaga February 14, 2019

Moyamoya syndrome (MMS) is an uncommon late complication after cranial irradiation. Its hemorrhagic presentation from the associated pseudo-aneurysm is extremely rare, and the optimal management strategy is undetermined. We herein report a 36-year-old man who developed intraventricular hemorrhage from a pseudo-aneurysm at the extended left anterior choroidal artery as an abnormal collateral of MMS 30 years after surgical removal and cranial irradiation for childhood craniopharyngioma.… Read More...

Owen Thomas, John Cain, Mehran Nasralla, Alan Jackson February 14, 2019

Introduction: To test the hypotheses that changes in the aortic pulse-wave produced by arterial stiffening are (1) propagated into cerebral small vessels, (2) associated with reduced compliance of small cerebral arterial vessels, and (3) associated with the presence of dilated perivascular spaces (PVS).… Read More...

Abhinav V. Kurada, Tarun Srinivasan, Sarah Hammond, Adriana Ulate-Campos, Jonathan Bidwell February 14, 2019

The need to address key limitations in validation studies is highlighted in order to support future assessments of SDD fitness for ASM clinical trial use. In tandem, a stepwise framework to streamline device testing is put forth. These suggestions provide a starting point for establishing SDD reporting requirements before device integration into ASM clinical trials.… Read More...

Jessica L. Kelleher, Paul Weiss, Amy D. Rodriguez, Joe R. Nocera, Monica C. Serra February 14, 2019

Background: Little is known about the body weight goals and trends of stroke survivors, despite evidence that overweight and obesity can negatively influence poststroke rehabilitation outcomes. Thus, the purpose of this study was to identify self-reported body weight trends over time in stroke survivors and nonstroke controls (50 years old) and describe the methods used to attempt to achieve body weight goals.… Read More...

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