Behavioral adaptation occurs rapidly, even after single errors. Perich et al. propose that the premotor cortex can exploit an “output-null” subspace to learn to adjust its output to downstream regions in response to behavioral errors.

Conditioned taste aversion (CTA) develops when ingestion of a novel food is accompanied by gastrointestinal malaise. Chen et al. demonstrate that parabrachial CGRP neurons are not only necessary for learning CTA but are also active during expression of those memories.

Harris et al. (2018) demonstrate that neuronal innate immune signaling coordinates the rapid induction and sustained expression of presynaptic homeostatic plasticity. Signaling includes the Map3K Tak1, which directly interfaces with the vesicle release machinery by stabilizing the docked synaptic vesicle state.… Read More...

PIEZO1 is an ion channel that converts mechanical stimuli into cellular signaling. Here, Chen et al. perform multi-species studies to define a feedforward circuit mediated by PIEZO1 and tumor tissue mechanics to promote glioma growth.

Kim et al. show that loss-of-function mutation of the chromatin regulator gene Chd2 produces deficits in neuron proliferation, synaptic function, and memory in mice.

Blanco-Suarez et al. identify that synapse maturation is not intrinsic to neurons but is regulated by neighboring astrocytes. They demonstrate that astrocyte-secreted Chrdl1 increases GluA2 AMPA receptor levels at synapses, inducing synapse maturation and inhibiting plasticity.

Lopes-dos-Santos et al. reveal that the cycle-to-cycle variability of CA1 theta oscillations, often averaged out as biological noise, reflects dynamic tuning of hippocampal operations related to different stages of memory processing.

Headache: The Journal of Head and Face Pain, EarlyView.

Headache: The Journal of Head and Face Pain, EarlyView.

Movement Disorders, EarlyView.