Nathan Harris, Richard D. Fetter, Daniel J. Brasier, Amy Tong, Graeme W. Davis October 18, 2018

Harris et al. (2018) demonstrate that neuronal innate immune signaling coordinates the rapid induction and sustained expression of presynaptic homeostatic plasticity. Signaling includes the Map3K Tak1, which directly interfaces with the vesicle release machinery by stabilizing the docked synaptic vesicle state.… Read More...

Elena Blanco-Suarez, Tong-Fei Liu, Alex Kopelevich, Nicola J. Allen October 18, 2018

Blanco-Suarez et al. identify that synapse maturation is not intrinsic to neurons but is regulated by neighboring astrocytes. They demonstrate that astrocyte-secreted Chrdl1 increases GluA2 AMPA receptor levels at synapses, inducing synapse maturation and inhibiting plasticity.

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Vítor Lopes-dos-Santos, Gido M. van de Ven, Alexander Morley, Stéphanie Trouche, Natalia Campo-Urriza, David Dupret October 18, 2018

Lopes-dos-Santos et al. reveal that the cycle-to-cycle variability of CA1 theta oscillations, often averaged out as biological noise, reflects dynamic tuning of hippocampal operations related to different stages of memory processing.

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