Although the administration of dopamine precursor levodopa remains as the mainstay for the treatment of Parkinson’s disease, long-term exposure to levodopa often causes a disabling complication, referred to as levodopa-induced dyskinesias. Therefore, the development of new therapeutic interventions to dampen levodopa-induced dyskinesias and parkinsonian motor deficits is needed in the treatment of Parkinson’s disease.… Read More...

Stanley et al. show that discrete, step-like gene expression heterogeneity defines four major striatal neuron types but does not provide spatial information. Within each discrete type, they find multiple axes of continuous, gradient-like heterogeneity that directly encode anatomical location.

Yoon et al. show that deubiquitination of proteins containing ankyrin-repeat domains is essential for the correct developmental trajectory of cortical synapses, with disruption of the deubiquitinase Usp9X resulting in deficient synaptic structural plasticity as well as behavioral and clinical abnormalities.

Deciding when to act is crucial for animals’ survival. Khalighinejad et al. used neuroimaging and ultrasound to identify a basal forebrain-cingulate circuit that tracks contextual factors in animals’ environments and mediates their effects on animals’ decisions about when to act.

Dementia, Ahead of Print.

Background: Evidence of the relationship between periodic limb movements during sleep (PLMS) and cerebral small vessel disease (cSVD) is limited and inconsistent. Here, we aimed to assess the independent association between PLMS and the different neuroimaging signatures of cSVD. Methods: Atahualpa residents aged more than or equal to 60 years enrolled in the Atahualpa Project undergoing polysomnography and MRI with time intervals less than or equal to 6 months were included.… Read More...

One of the rare joys of compiling a special edition for a Journal is being able to write a more informal prologue. On putting this collection of manuscripts together, I was reminded of a comment made to me by a rather portly, now rather famous, London nephrologist while I was a junior doctor.… Read More...

A subset of ischemic stroke patients present with blood pressures above that considered safe for thrombolytic administration, requiring antihypertensive therapy. Guideline statements are ambivalent regarding which antihypertensive agent should be used to obtain a satisfactory blood pressure < 185/110 mm Hg prior to alteplase.

Troponin is a marker of cardiac ischemia and is elevated in about 30% of stroke patients. We investigated if the elevation of troponin during an acute stroke code is associated with a cardioembolic source.

Differentiating stroke due to Trousseau’s syndrome from other types of cerebral embolism is challenging, especially in patients with occult cancer. The current study aimed to determine predicting factors and biomarkers of stroke due to Trousseau’s syndrome.