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Periaqueductal gray functional connectivity abnormalities associated with acute post-traumatic headache

by myneuronews April 23, 2025

by myneuronews April 23, 2025

J Neurol. 2025 Apr 23;272(5):356. doi: 10.1007/s00415-025-13098-w. ABSTRACT BACKGROUND: The purpose of this study was …

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The Effects of High-Intensity Interval Training on Both Physical and Cognitive Performance and Recovery

by myneuronews April 23, 2025

by myneuronews April 23, 2025

J Strength Cond Res. 2025 May 1;39(5):547-552. doi: 10.1519/JSC.0000000000005067. ABSTRACT Weisman, I, Ben-Zeev, T, Alon, …

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Supportive Elements and Challenges to Return to Work Following a Concussion: A Scoping Review

by myneuronews April 23, 2025

by myneuronews April 23, 2025

J Head Trauma Rehabil. 2025 Apr 22. doi: 10.1097/HTR.0000000000001064. Online ahead of print. ABSTRACT OBJECTIVE: …

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Incidence and Risk Factors for Tinnitus Among Military Service Members in the Millennium Cohort Study

by myneuronews April 23, 2025

by myneuronews April 23, 2025

Am J Audiol. 2025 Apr 23:1-14. doi: 10.1044/2025_AJA-24-00198. Online ahead of print. ABSTRACT PURPOSE: Military …

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Trajectory of Post-Traumatic Stress During the First Year after Pediatric Traumatic Brain or Orthopedic Injury

by myneuronews April 22, 2025

by myneuronews April 22, 2025

J Neurotrauma. 2025 Apr 22. doi: 10.1089/neu.2024.0578. Online ahead of print. ABSTRACT Up to 50% …

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Predictors and outcomes of sleep problems following childhood traumatic brain injury: A prospective cohort study

by myneuronews April 22, 2025

by myneuronews April 22, 2025

Ann Phys Rehabil Med. 2025 Apr 21;68(5):101958. doi: 10.1016/j.rehab.2025.101958. Online ahead of print. ABSTRACT BACKGROUND: …

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TRANSCENDENT (Transforming Research by Assessing Neuroinformatics across the Spectrum of Concussion by Embedding iNterdisciplinary Data-collection to Enable Novel Treatments): protocol for a prospective observational cohort study of concussion patients with embedded comparative effectiveness research within a network of learning health system concussion clinics in Canada

by myneuronews April 22, 2025

by myneuronews April 22, 2025

BMJ Open. 2025 Apr 22;15(4):e095292. doi: 10.1136/bmjopen-2024-095292. ABSTRACT INTRODUCTION: Concussion affects over 400 000 Canadians …

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Trajectory of Post-Traumatic Stress During the First Year after Pediatric Traumatic Brain or Orthopedic Injury

by myneuronews April 22, 2025

by myneuronews April 22, 2025

J Neurotrauma. 2025 Apr 22. doi: 10.1089/neu.2024.0578. Online ahead of print. ABSTRACT Up to 50% …

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Predictors and outcomes of sleep problems following childhood traumatic brain injury: A prospective cohort study

by myneuronews April 22, 2025

by myneuronews April 22, 2025

Ann Phys Rehabil Med. 2025 Apr 21;68(5):101958. doi: 10.1016/j.rehab.2025.101958. Online ahead of print. ABSTRACT BACKGROUND: …

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TRANSCENDENT (Transforming Research by Assessing Neuroinformatics across the Spectrum of Concussion by Embedding iNterdisciplinary Data-collection to Enable Novel Treatments): protocol for a prospective observational cohort study of concussion patients with embedded comparative effectiveness research within a network of learning health system concussion clinics in Canada

by myneuronews April 22, 2025

by myneuronews April 22, 2025

BMJ Open. 2025 Apr 22;15(4):e095292. doi: 10.1136/bmjopen-2024-095292. ABSTRACT INTRODUCTION: Concussion affects over 400 000 Canadians …

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The Recovery Journey from Mild Traumatic Brain Injury
by Ioannis Mavroudis
This article delves into the nuanced recovery process from Mild Traumatic Brain Injury (mTBI), detailing the phases from immediate post-injury through long-term adaptation. It emphasizes the variability of recovery trajectories and the comprehensive strategies needed to support healing. The early recovery phase stresses rest and symptom management, while intermediate recovery introduces rehabilitation therapies. Long-term recovery discusses ongoing support for persistent challenges. The critical role of support systems is highlighted, underscoring the importance of emotional, social, and professional resources in fostering resilience and promoting a successful adjustment to life post-mTBI. This guide aims to provide patients and caregivers with a roadmap for navigating the complex recovery landscape, advocating for a patient-centered approach to rehabilitation and reintegration.
Understanding Mild Traumatic Brain Injury (mTBI): An Overview
by Ioannis Mavroudis
This article provides a comprehensive overview of Mild Traumatic Brain Injury (mTBI), focusing on its causes, symptoms, diagnosis, treatment, and management. mTBI, often known as a concussion, arises from sudden trauma to the head, leading to temporary disruptions in brain function. The diversity of mTBI symptoms—ranging from physical and cognitive to emotional—highlights the complexity of this condition. Diagnosis primarily involves a detailed medical evaluation, as imaging tests may not always detect the injury. Treatment strategies emphasize rest and gradual re-engagement with daily activities, alongside potential therapies for specific symptoms. This overview underscores the importance of early recognition and intervention in mitigating the effects of mTBI and supporting recovery, advocating for prompt medical attention and tailored management plans to ensure the best possible outcomes for affected individuals.
Understanding Traumatic Encephalopathy Syndrome (TES): A Comprehensive Overview
by Ioannis Mavroudis
Traumatic Encephalopathy Syndrome demands a multidisciplinary approach to tackle its complexities. By advancing our understanding of TES through research, refining diagnostic criteria, and enhancing prevention and treatment strategies, we can better support those affected by this challenging syndrome. The path ahead calls for collaboration among researchers, clinicians, and stakeholders to safeguard brain health in populations at risk and ensure a future where the impacts of repetitive head trauma are fully understood and effectively managed.
Harmonizing Recovery: The Role of Music in mTBI and PCS Rehabilitation
by Ioannis Mavroudis
This article explores the therapeutic potential of music in the rehabilitation of individuals recovering from mild Traumatic Brain Injury (mTBI) and Post-Concussion Syndrome (PCS). It delves into how music therapy, through cognitive, emotional, and physical dimensions, can aid in the holistic recovery process. Cognitive improvements are highlighted by music's ability to enhance memory, attention, and executive functions. The emotional support provided by music therapy offers relief from depression, anxiety, and stress, while its rhythmic elements assist in physical rehabilitation, improving coordination and movement. Furthermore, music therapy fosters social connections, enhancing the sense of community among individuals undergoing recovery. This comprehensive approach underscores the multifaceted benefits of music therapy in addressing the challenges faced by those recovering from mTBI and PCS.
Salivary biomarkers in Post-concussion syndrome
by Ioannis Mavroudis
Traumatic brain injuries (TBIs), particularly mild TBIs, present a complex diagnostic challenge due to their subtle manifestations and the broad spectrum of potential long-term consequences, including post-concussion syndrome (PCS) and chronic traumatic encephalopathy (CTE). The search for reliable diagnostic markers has led to the exploration of salivary biomarkers as a non-invasive, cost-effective means of detecting TBIs and assessing their severity. This review examines the role of salivary biomarkers—S100B, Neurofilament Light Chain (NfL), microRNAs (miRNAs), and Extracellular Vesicles (EVs)—in the diagnosis of TBIs and PCS. Elevated levels of S100B are associated with brain damage, suggesting its potential as an indicator of TBI. NfL, a marker of axonal injury, offers insights into the severity of neural damage. Altered miRNA profiles in saliva can reflect changes in gene expression related to neural injury, providing a molecular signature of TBI and PCS. Furthermore, EVs carry a cargo reflective of cellular and molecular changes post-injury, serving as a promising diagnostic tool. This review highlights the emerging significance of these salivary biomarkers in the early detection and management of TBIs, underscoring the need for further research to validate their clinical utility and integrate them into standard diagnostic protocols.

Can the Association of the Biomarkers GFAP and UCH-L1 Predict Intracranial Injury After Mild Traumatic Brain Injury in Adults? A Systematic Review and Meta-Analysis
CONCLUSION: The combined measurement of GFAP and UCH-L1 allows the exclusion of intracranial injury after mTBI in adults with 100% Se and negative predictive value. Its routine use can theoretically reduce the number of cranial computed tomography scans by 31%. The different sampling times and techniques used in the studies did not allow us to […]
Validation of Strategic Memory Advanced Reasoning Training as an efficient and effective approach to treating warfighters with persistent cognitive complaints associated with mild traumatic brain injury
INTRODUCTION: This study directly compared the relative effectiveness of Strategic Memory Advanced Reasoning Training (SMART), which focuses on metacognitive strategies, to a traditional cognitive rehabilitation (CR) program previously developed and validated for the Study of Cognitive Rehabilitation Effectiveness study (SCORE), in treating warfighters with a history of mild traumatic brain injury (mTBI) and persistent post-concussive […]
What Factors Influence Head Acceleration During a Purposeful Header in Soccer Players? A Systematic Review
BACKGROUND: Head acceleration is often used as a proxy measurement for concussion risk. It is unclear what factors contribute to head acceleration during a purposeful header.
Investigating omega-3 fatty acids' neuroprotective effects in repetitive subconcussive neural injury: Study protocol for a randomized placebo-controlled trial
Soccer (football) is the most popular sport globally, with 265 million players across all ages and sexes. Repetitive subconcussive head impacts due to heading of the soccer ball can pose threats to healthy brain development and aging. Omega-3 fatty acids, especially docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), may have neuroprotective effects, but it remains […]
Predicting hospital outcomes in concussion and TBI: A mixed-effects analysis utilizing the nationwide readmissions database
CONCLUSION: Using an advanced mixed-effects model, our study found that GCS is an accurate predictor of hospital outcomes after a TBI diagnosis. These results provide insight that may aid in the development of preventative strategies, management decisions, and patient counseling to ensure a safe return to daily life for patients diagnosed with concussion.